The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Challenges in circulating tumor cell detection by the CellSearch system
Open accessAbstract
Enumeration and characterization of circulating tumor cells (CTC) hold the promise of a real time liquid biopsy. They are however present in a large background of hematopoietic cells making their isolation technically challenging. In 2004, the CellSearch system was introduced as the first and only FDA cleared method designed for the enumeration of circulating tumor cells in 7.5 mL of blood. Presence of CTC detected by CellSearch is associated with poor prognosis in metastatic carcinomas. CTC remaining in patients after the first cycles of therapy indicates a futile therapy. Here we review challenges faced during the development of the CellSearch system and the difficulties in assigning objects as CTC. The large heterogeneity of CTC and the different approaches introduced in recent years to isolate, enumerate and characterize CTC results in a large variation of the number of CTC reported urging the need for uniform definitions and at least a clear definition of what the criteria are for assigning an object as a CTC.
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Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Cristofanilli, M., Budd, G. T., Ellis, M. J., Stopeck, A., Matera, J., Miller, M. C., Reuben, J. M., Doyle, G. V., Allard, W. J., Terstappen, L. W. M. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040766 · Cited by 4,593
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Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
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Self-citationCohen, S. J., Punt, C. J. A., Iannotti, N., Saidman, B. H., Sabbath, K. D., Gabrail, N. Y., Picus, J., Morse, M., Mitchell, E., Miller, M. C., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.8923 · Cited by 1,841
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Challenges in circulating tumour cell research
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Circulating Tumor Cells: A Novel Prognostic Factor for Newly Diagnosed Metastatic Breast Cancer
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Self-citationCirculating Tumor Cells in Patients with Breast Cancer Dormancy
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Jiang, J., Zhao, H., Shu, W., Tian, J., Huang, Y., Song, Y., Wang, R., Li, E., Slamon, D., Hou, D., et al. (2017) · Scientific Reports · doi:10.1038/srep42612 · Cited by 66
Prognostic and clinicopathological significance of circulating tumor cells in osteosarcoma
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Metadata
- Authors
- Andree, K. C., van Dalum, G., & Terstappen, L. W. M. M.
- Venue
- Molecular Oncology
- Publisher
- Wiley
- Published
- 2015-12-25
- Volume
- 10
- Issue
- 3
- Pages
- 395-407
- ISSN
- 1574-7891 (ISSN-L)
- 1878-0261
- OpenAlex
- W2199872895
- Cited by
- 363
- References
- 85
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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