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An integrated microfluidic device for rapid and high-sensitivity analysis of circulating tumor cells
Open accessAbstract
Recently there has been a more focus on the development of an efficient technique for detection of circulating tumor cells (CTCs), due to their significance in prognosis and therapy of metastatic cancer. However, it remains a challenge because of the low count of CTCs in the blood. Herein, a rapid and high-sensitivity approach for CTCs detection using an integrated microfluidic system, consisting of a deterministic lateral displacement (DLD) isolating structure, an automatic purifying device with CD45-labeled immunomagnetic beads and a capturing platform coated with rat-tail collagen was reported. We observed high capture rate of 90%, purity of about 50% and viability of more than 90% at the high throughput of 1 mL/min by capturing green fluorescent protein (GFP)-positive cells from blood. Further capturing of CTCs from metastatic cancers patients revealed a positive capture rate of 83.3%. Furthermore, our device was compared with CellSearch system via parallel analysis of 30 cancer patients, to find no significant difference between the capture efficiency of both methods. However, our device displayed advantage in terms of time, sample volume and cost for analysis. Thus, our integrated device with sterile environment and convenient use will be a promising platform for CTCs detection with potential clinical application.
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Negative enrichment for CTC isolation usually aims to capture or eliminate WBCs in blood using CD45-labelled immunomagnetic beads.
“Negative enrichment for CTC isolation usually aims to capture or eliminate the WBCs in blood using CD45-labelled immunomagnetic beads.”
From Dynamic Halbach array magnet integrated microfluidic system for the continuous-flow separation of rare tumor cells (2019) · cites this paper as [37]
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Cites
Siegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003
A Perspective on Cancer Cell Metastasis
Chaffer, C. L., & Weinberg, R. A. (2011) · Science · doi:10.1126/science.1203543 · Cited by 4,905
Isolation of rare circulating tumour cells in cancer patients by microchip technology
Nagrath, S., Sequist, L. V. D., Maheswaran, S., Bell, D. W., Irimia, D., Ulkus, L., Smith, M. R., Kwak, E. L., Digumarthy, S. R., Muzikansky, A., et al. (2007) · Nature · doi:10.1038/nature06385 · Cited by 3,595
Allard, W. J., Matera, J., Miller, M. C., Repollet, M., Connelly, M. C., Rao, C., Tibbe, A. G. J., Uhr, J. W., & Terstappen, L. W. M. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0378 · Cited by 2,542
Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
Aceto, N., Bardia, A., Miyamoto, D. T., Collier, M. D., Wittner, B. S., Spencer, J. A., Yu, M., Pely, A., Engstrom, A., Zhu, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.013 · Cited by 2,516
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Yu, M., Bardia, A., Wittner, B. S., Stott, S. L., Smas, M. E., Ting, D. T., Isakoff, S. J., Ciciliano, J. C., Wells, M. N., Shah, A. M., et al. (2013) · Science · doi:10.1126/science.1228522 · Cited by 2,476
Biomarkers for epithelial-mesenchymal transitions
Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299
Challenges in circulating tumour cell research
Alix‐Panabières, C., & Pantel, K. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3820 · Cited by 1,334
Emre Özkumur, A., Shah, A. M., Ciciliano, J. C., Emmink, B. L., Miyamoto, D. T., Brachtel, E. F., Yu, M., Chen, P.-I., Morgan, B., Trautwein, J., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005616 · Cited by 1,100
RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance
Miyamoto, D. T., Zheng, Y., Wittner, B. S., Lee, R. J., Zhu, H., Broderick, K. T., Desai, R. N., Fox, D. B., Brannigan, B. W., Trautwein, J., et al. (2015) · Science · doi:10.1126/science.aab0917 · Cited by 716
Molecular analysis of circulating tumour cells—biology and biomarkers
Krebs, M., Metcalf, R. L., Carter, L., Brady, G., Blackhall, F. H., & Dive, C. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2013.253 · Cited by 638
Dynamic self-assembly of magnetized, millimetre-sized objects rotating at a liquid–air interface
Grzybowski, B. A., Stone, H. A., & Whitesides, G. M. (2000) · Nature · doi:10.1038/35016528 · Cited by 537
Attard, G., Swennenhuis, J. F., Olmos, D., Reid, A. H. M., Vickers, E., A'Hern, R., Levink, R., Coumans, F., Moreira, J., Riisnaes, R., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3667 · Cited by 533
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
Lu, H., Clauser, K. R., Tam, W. L., Fröse, J., Ye, X., Eaton, E. N., Reinhardt, F., Donnenberg, V. S., Bhargava, R., Carr, S. A., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3041 · Cited by 464
Gupta, V., Jafferji, I., Garza, M., Melnikova, V. O., Hasegawa, D. K., Pethig, R., & Davis, D. W. (2012) · Biomicrofluidics · doi:10.1063/1.4731647 · Cited by 398
Xu, H., Aguilar, Z. P., Yang, L., Kuang, M., Duan, H., Xiong, Y., Wei, H., & Wang, A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.076 · Cited by 381
Challenges in circulating tumor cell detection by the CellSearch system
Andree, K., van Dalum, G., & Terstappen, L. W. M. M. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.12.002 · Cited by 365
Xu, Z., Gao, Y., Hao, Y., Li, E., Wang, Y., Zhang, J., Wang, W., Gao, Z., & Wang, Q. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.045 · Cited by 295
Self-citationDeterministic Separation of Cancer Cells from Blood at 10 mL/minPreprint
Loutherback, K., D'Silva, J., Liu, L., Wu, A. Y., Austin, R. H., & Sturm, J. C. (2012) · Nature Precedings · doi:10.1063/1.4758131 · Cited by 273
Systematic Identification of Signal-Activated Stochastic Gene Regulation
Neuert, G., Munsky, B. E., Tan, R. Z., Teytelman, L., Khammash, M., & van Oudenaarden, A. (2013) · Science · doi:10.1126/science.1231456 · Cited by 255
Olmos, D., Arkenau, H., Ang, J. E., Ledaki, I., Attard, G., Carden, C. P., Reid, A. H. M., A’Hern, R., Fong, P. C. C., Oommen, N. B., et al. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn544 · Cited by 243
Circulating Tumor Cells: A Multifunctional Biomarker
Yap, T. A., Lorente, D., Omlin, A. G., Olmos, D., & Bono, J. S. D. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2664 · Cited by 214
Harb, W. A., Fan, A. R., Tran, T. T., Danila, D. C., Keys, D. N., Schwartz, M. A., & Ionescu‐Zanetti, C. (2013) · Translational Oncology · doi:10.1593/tlo.13367 · Cited by 211
The CTC-Chip: An Exciting New Tool to Detect Circulating Tumor Cells in Lung Cancer Patients
Sequist, L. V. D., Nagrath, S., Toner, M., Haber, D. A., & Lynch, T. J. (2009) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181989565 · Cited by 194
Challenges in the Enumeration and Phenotyping of CTC
Coumans, F. A. W., Ligthart, S. T., Uhr, J. W., & Terstappen, L. W. M. M. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1585 · Cited by 190
Fan, X., Jia, C., Yang, J., Li, G., Mao, H., Jin, Q., & Zhao, J. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.04.080 · Cited by 184
Probing circulating tumor cells in microfluidics
Li, P., Stratton, Z. S., Dao, M., Ritz, J., & Huang, T. J. (2013) · Lab on a Chip · doi:10.1039/c2lc90148j · Cited by 171
Improved performance of deterministic lateral displacement arrays with triangular posts
Loutherback, K., Chou, K. S., Newman, J., Puchalla, J., Austin, R. H., & Sturm, J. C. (2010) · Microfluidics and Nanofluidics · doi:10.1007/s10404-010-0635-y · Cited by 162
CD47 Promotes Tumor Invasion and Metastasis in Non-small Cell Lung Cancer
Zhao, H., Wang, J., Kong, X., Li, E., Liu, Y., Du, X., Kang, Z., Tang, Y. C., Kuang, Y., Yang, Z., et al. (2016) · Scientific Reports · doi:10.1038/srep29719 · Cited by 152
Self-citationLi, X., Chen, W., Liu, G., Lu, W. D., & Fu, J. (2014) · Lab on a Chip · doi:10.1039/c4lc00350k · Cited by 142
The isolation and characterization of CTC subsets related to breast cancer dormancy
Vishnoi, M., Peddibhotla, S., Yin, W., Scamardo, A. T., George, G. C., Hong, D. S., & Marchetti, D. (2015) · Scientific Reports · doi:10.1038/srep17533 · Cited by 125
Microfluidic enrichment for the single cell analysis of circulating tumor cells
Yeo, T., Tan, S. J., Lim, C. L., Lau, D. P. X., Chua, Y. W., Krisna, S. S., Iyer, G., Tan, G. S., Lim, T. K. H., Tan, D. S. W., et al. (2016) · Scientific Reports · doi:10.1038/srep22076 · Cited by 123
Wang, C., Ye, M., Cheng, L., Li, R., Zhu, W., Shi, Z. Y., Fan, C., He, J., Liu, J., & Liu, Z. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.03.004 · Cited by 114
Cima, I., Yee, C. W., Iliescu, F. S., Phyo, W. M., Lim, K. H., Iliescu, C., & Tan, M. H. (2013) · Biomicrofluidics · doi:10.1063/1.4780062 · Cited by 106
High throughput capture of circulating tumor cells using an integrated microfluidic system
Liu, Z., Zhang, W., Huang, F., Feng, H., Shu, W., Xu, X., & Chen, Y. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.03.017 · Cited by 104
Self-citationTwo-stage microfluidic chip for selective isolation of circulating tumor cells (CTCs)
Hyun, K.-A., Lee, T. Y., Lee, S. H., & Jung, H. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.07.019 · Cited by 97
Lu, N.-N., Xie, M., Wang, J., Lv, S., Yi, J., Dong, W., & Huang, W. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01397 · Cited by 97
Chiu, T.-K., Chou, W.-P., Huang, S.-B., Wang, H., Lin, Y., Hsieh, C., & Wu, M. (2016) · Scientific Reports · doi:10.1038/srep32851 · Cited by 91
A label-free DC impedance-based microcytometer for circulating rare cancer cell counting
Choi, H., Kim, K. B., Jeon, C. S., Hwang, I., Lee, S., Kim, H. K., Kim, H. C., & Chung, T. D. (2013) · Lab on a Chip · doi:10.1039/c2lc41376k · Cited by 69
Exploiting mechanical biomarkers in microfluidics
Mao, X., & Huang, T. J. (2012) · Lab on a Chip · doi:10.1039/c2lc90100e · Cited by 63
Screening and Molecular Analysis of Single Circulating Tumor Cells Using Micromagnet Array
Huang, Y.-Y., Chen, P., Wu, C.-H., Hoshino, K., Sokolov, K., Lane, N., Liu, H., Huebschman, M. L., Frenkel, E. P., & Zhang, J. X. J. (2015) · Scientific Reports · doi:10.1038/srep16047 · Cited by 57
Self-citationGuo, S., Xu, J., Xie, M., Huang, W., Yuan, E., Liu, Y., Fan, L., Cheng, S., Liu, S., Wang, F., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b04002 · Cited by 57
Adams, D. L., Alpaugh, R. K., Tsai, S., Tang, C., & Stefansson, S. (2016) · Scientific Reports · doi:10.1038/srep33488 · Cited by 49
de Albuquerque, A., Kaul, S., Breier, G., Krabisch, P., & Fersis, N. (2012) · Breast Care · doi:10.1159/000336548 · Cited by 41
Gach, P. C., Attayek, P. J., Whittlesey, R. L., Yeh, J. J., & Allbritton, N. L. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.11.019 · Cited by 21
[The circulating tumor cells: liquid biopsy of cancer].
Alix‐Panabières, C., & Pantel, K. (2014) · PubMed · Cited by 21
Shao, J., Zhou, S., Zhou, J., Chi, T., Ma, J., Kuo, M., Lee, A. Y., & Jia, L. (2016) · Scientific Reports · doi:10.1038/srep30549 · Cited by 20
Analysis of chemoresistance in lung cancer with a simple microfluidic device
Zhang, L., Wang, J., Zhao, L., Meng, Q., & Wang, Q. (2010) · Electrophoresis · doi:10.1002/elps.201000265 · Cited by 14
Self-citationMeng, Q., He, Z., Zhang, L., Zhao, L., Li, E., Zhang, Q., Zhang, X., Yang, D., Zou, L., Gao, Z., et al. (2011) · Electrophoresis · doi:10.1002/elps.201100086 · Cited by 7
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Alix-Panabières, C. & Pantel, K. Challenges in circulating tumor cell research. Nat Rev Cancer 14, 623–31(2014). · DOI
Cited by
Sorted by citations
Recent advances in microfluidic cell sorting systems
Shen, Y., Yalikun, Y., & Tanaka, Y. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.11.025 · Cited by 207
Management and potentialities of primary cancer cultures in preclinical and translational studies
Miserocchi, G., Mercatali, L., Liverani, C., Vita, A. D., Spadazzi, C., Pieri, F., Bongiovanni, A., Recine, F., Amadori, D., & Ibrahim, T. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1328-z · Cited by 126
Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering
Yaman, S., Anıl-İnevi, M., Özçivici, E., & Tekin, H. C. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00192 · Cited by 111
Microfluidics for studying metastatic patterns of lung cancer
Ruzycka-Ayoush, M., Cimpan, M. R., Ríos-Mondragón, I., & Grudziński, I. P. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0492-0 · Cited by 84
Tang, H., Niu, J., Jin, H., Lin, S., & Cui, D. (2022) · Microsystems & Nanoengineering · doi:10.1038/s41378-022-00386-y · Cited by 84
Clack, K., Soda, N., Kasetsirikul, S., Mahmudunnabi, R. G., Nguyen, N., & Shiddiky, M. J. A. (2023) · Small · doi:10.1002/smll.202205856 · Cited by 68
Magnetically driven microfluidics for isolation of circulating tumor cells
Luo, L., & He, Y. (2020) · Cancer Medicine · doi:10.1002/cam4.3077 · Cited by 67
Zhao, B., Cui, X., Ren, W., Xu, F., Liu, M., & Ye, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-10785-1 · Cited by 58
Li, Y., Zhang, H.-N., Li, Y., Li, X., Wu, J., Qian, S., & Li, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-21827-7 · Cited by 56
Detection and clinical significance of circulating tumor cells in colorectal cancer
Jiang, M., Jin, S., Han, J., Li, T., Shi, J., Zhong, Q., Li, W., Tang, W., Huang, Q., & Zong, H. (2021) · Biomarker Research · doi:10.1186/s40364-021-00326-4 · Cited by 54
Chu, C., Liu, R., Ozkaya‐Ahmadov, T., Boya, M., Swain, B. E., Owens, J. M., Burentugs, E., Bilen, M. A., McDonald, J. F., & Sarioglu, A. F. (2019) · Lab on a Chip · doi:10.1039/c9lc00575g · Cited by 53
Prognostic and therapeutic significance of circulating tumor cells in patients with lung cancer
Yousefi, M., Ghaffari, P., Nosrati, R., Dehghani, S., Salmaninejad, A., Abarghan, Y. J., & Ghaffari, S. H. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00470-y · Cited by 48
Progress in Circulating Tumor Cell Research Using Microfluidic Devices
Gwak, H., Kim, J., Kashefi‐Kheyrabadi, L., Kwak, B., Hyun, K.-A., & Jung, H. (2018) · Micromachines · doi:10.3390/mi9070353 · Cited by 43
Recent advances in integrated microfluidics for liquid biopsies and future directions
Zhuang, J., Xia, L., Zou, Z., Yin, J., Lin, N., & Mu, Y. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114715 · Cited by 43
Microfluidic device for both active and passive cell separation techniques: A review
Mansor, M. A., Jamrus, M. A., Chong, K. L., Ahmad, M. R., Petrů, M., & Koloor, S. S. R. (2024) · Sensors and Actuators Reports · doi:10.1016/j.snr.2024.100277 · Cited by 40
Circulating tumor cells in colorectal cancer in the era of precision medicine
Hu, M., Wang, Z., Wu, Z., Ding, P., Pei, R., Wang, Q., & Xing, C. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02162-3 · Cited by 38
Self-citationLeValley, P. J., Tibbitt, M. W., Noren, B. E., Kharkar, P. M., Kloxin, A. M., Anseth, K. S., Toner, M., & Oakey, J. S. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.11.049 · Cited by 36
Xu, M., Zhao, H., Chen, J., Liú, W., Li, E., Wang, Q., & Zhang, L. (2019) · Cytometry Part A · doi:10.1002/cyto.a.23902 · Cited by 35
Self-citationLu, C., Han, J., Sun, X., & Yang, G. (2020) · Sensors · doi:10.3390/s20216073 · Cited by 33
Baseline circulating stem-like cells predict survival in patients with metastatic breast Cancer
Lee, C., Hsieh, C., Wu, T. M., Yeh, T.-S., Wang, H., Lin, Y., Chen, J., Lee, C.-L., Huang, W., Hung, T., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-6370-1 · Cited by 30
Topology optimization based deterministic lateral displacement array design for cell separation
Tang, H., Niu, J., Pan, X., Jin, H., Lin, S., & Cui, D. (2022) · Journal of Chromatography A · doi:10.1016/j.chroma.2022.463384 · Cited by 30
Jibin, K., Babu, R., V, & Jayasree, R. S. (2021) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.1c05084 · Cited by 29
Computational Fluid–Structure Interaction in Microfluidics
Musharaf, H. M., Roshan, U., Mudugamuwa, A., Trịnh, Q. T., Zhang, J., & Nguyen, N. (2024) · Micromachines · doi:10.3390/mi15070897 · Cited by 29
Xue, M., Xiang, A., Guo, Y., Wang, L., Wang, R., Wang, W., Ji, G., & Lu, Z. (2019) · RSC Advances · doi:10.1039/c9ra08285a · Cited by 26
Self-citationThe integrated on-chip isolation and detection of circulating tumour cells
Abusamra, S. M., Barber, R., Sharafeldin, M., Edwards, C. M., & Davis, J. J. (2024) · Sensors & Diagnostics · doi:10.1039/d3sd00302g · Cited by 26
A microfluidic platform for high-purity separating circulating tumor cells at the single-cell level
Wang, K., Zhou, L., Zhao, S., Cheng, Z., Qiu, S., Lu, Y., Wu, Z., Wahab, A. H. A. A., Mao, H., & Zhao, J. (2019) · Talanta · doi:10.1016/j.talanta.2019.03.035 · Cited by 26
Li, X., Cui, T., Zhang, W., Zhai, Z., Wu, F., Zhang, Y., Yang, M., Zhong, W., & Yue, W. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111281 · Cited by 25
Carvalho, S., Abreu, C. M., Ferreira, D., Lima, L., Ferreira, J. A., Santos, L. L., Ribeiro, R. J. T., Grenha, V., Martínez‐Fernández, M., Dueñas, M., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01774 · Cited by 24
Microfluidic Blood Separation: Key Technologies and Critical Figures of Merit
Torres‐Castro, K., Acuña-Umaña, K., Lesser‐Rojas, L., & Reyes, D. R. (2023) · Micromachines · doi:10.3390/mi14112117 · Cited by 22
Novel Isolating Approaches to Circulating Tumor Cell Enrichment Based on Microfluidics: A Review
Qiao, Z., Teng, X., Liu, A., & Yang, W. (2024) · Micromachines · doi:10.3390/mi15060706 · Cited by 21
Liu, H., Koch, C., Haller, A., Joosse, S. A., Kumar, R. K., Vellekoop, M. J., Horst, L. J., Keller, L., Babayan, A., Failla, A. V., et al. (2019) · Advanced Biosystems · doi:10.1002/adbi.201900162 · Cited by 21
Escobar, A., Chiu, P., Qu, J., Zhang, Y., & Xu, C. (2021) · Micromachines · doi:10.3390/mi12091079 · Cited by 20
Signal amplification strategies in biosensing of extracellular vesicles (EVs)
Khaksari, S., Abnous, K., Hadizadeh, F., Ramezani, M., Taghdisi, S. M., & Shaegh, S. A. M. (2022) · Talanta · doi:10.1016/j.talanta.2022.124244 · Cited by 19
Nakamura, M., Ono, D., & Sugita, S. (2019) · Micromachines · doi:10.3390/mi10030207 · Cited by 19
Microfluidic Mimic for Colloid Membrane Filtration: A Review
Debnath, N., & Sadrzadeh, M. (2018) · Journal of the Indian Institute of Science · doi:10.1007/s41745-018-0071-7 · Cited by 18
Chang, P., Wu, M., Liu, S.-Y., Wang, H., Huang, W., Liao, C., Yen, T., Ng, S., Chen, J., Lin, Y., et al. (2019) · Cancers · doi:10.3390/cancers11040540 · Cited by 17
Lusk, J. F., Miranda, C., Howell, M. R., Chrest, M., Eshima, J., & Smith, B. S. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01217 · Cited by 16
Chu, C., Liu, R., Ozkaya‐Ahmadov, T., Swain, B. E., Boya, M., El‐Rayes, B. F., Akce, M., Bilen, M. A., Küçük, Ö., & Sarioglu, A. F. (2021) · Scientific Reports · doi:10.1038/s41598-021-99951-0 · Cited by 16
Pham, Q. L., Tong, N. A. N., Mathew, A., Basuray, S., & Voronov, R. S. (2018) · Biomicrofluidics · doi:10.1063/1.5035282 · Cited by 14
Mirhosseini, S., Eskandarisani, M., Nasiri, A. F., Khatami, F., Mirzaei, A., Badieirostami, M., Aghamir, S. M. K., & Kolahdouz, M. (2024) · Biosensors · doi:10.3390/bios14100466 · Cited by 13
Toward a Soft Microfluidic System: Concept and Preliminary Developments
Tony, A., Rasouli, A., Farahinia, A., Wells, G., Zhang, H., Achenbach, S. C., Yang, S., Sun, W. M., & Zhang, W. (2021) · International Conference on Mechatronics and Machine Vision in Practice (M2VIP) · doi:10.1109/m2vip49856.2021.9665022 · Cited by 13
Sano, H., Kazoe, Y., Ohta, R., Shimizu, H., Morikawa, K., & Kitamori, T. (2022) · Lab on a Chip · doi:10.1039/d2lc00881e · Cited by 12
Bead-free digital immunoassays on polydopamine patterned perfluorinated surfaces
Qian, S., Wu, H., Huang, B., Liu, Q., Chen, Y., & Zheng, B. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.130341 · Cited by 11
Self-citationXu, M., Liu, W., Zou, K., Wei, S., Zhang, X., Li, E., & Wang, Q. (2021) · Micromachines · doi:10.3390/mi12010049 · Cited by 11
Self-citationMarhenke, J., Dirnecker, T., Vogel, N., & Rommel, M. (2022) · Microfluidics and Nanofluidics · doi:10.1007/s10404-022-02609-0 · Cited by 11
Clog-free high-throughput microfluidic cell isolation with multifunctional microposts
Venugopal, D., Kasani, N., Manjunath, Y., Li, G., Kaifi, J. T., & Kwon, J. W. (2021) · Scientific Reports · doi:10.1038/s41598-021-94123-6 · Cited by 10
Jahangiri, M., Khosravi, S., Moghtaderi, H., Ranjbar, M., Abadijoo, H., Sarmadi, S., Izadi‐Mood, N., Shirali, E., Hoseinpour, P., Gity, M., et al. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.126733 · Cited by 10
Mu, H., Ou, Y., Chuang, H., Lu, T., Jhan, P., Hsiao, T., & Huang, J. (2020) · Advanced Biosystems · doi:10.1002/adbi.202000013 · Cited by 10
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Smiljanić, M., Lazić, Ž., Jović, V. B., Radjenović, B., & Radmilović-Radjenović, M. (2020) · Micromachines · doi:10.3390/mi11030253 · Cited by 8
Zhang, L., Li, Q., Yang, R., Xu, Z., Kang, Y., & Xue, P. (2019) · Biomedical Microdevices · doi:10.1007/s10544-019-0418-5 · Cited by 7
Self-citationMicrofluidic separation device for blood components with lipids and cancer cells
Ramya, S., Kumar, S., Caffiyar, M. Y., & Hemamalini, N. V. (2024) · Microsystem Technologies · doi:10.1007/s00542-024-05793-x · Cited by 5
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Sano, H., Kazoe, Y., Morikawa, K., & Kitamori, T. (2023) · Journal of Micromechanics and Microengineering · doi:10.1088/1361-6439/ace05f · Cited by 4
Deng, Y., Sun, L., Liang, H., Cui, B., Cui, C., Zhao, D., Wan, A. H., & Wan, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.760765 · Cited by 4
Marhenke, J., Dirnecker, T., Vogel, N., & Rommel, M. (2023) · Microfluidics and Nanofluidics · doi:10.1007/s10404-023-02685-w · Cited by 2
Noguchi, S., & Ueno, I. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.12.168 · Cited by 2
Cheng, Y., Shen, J., Yuan, L., Yan, Y., Shen, X., Qian, H., Yu, L., Li, R., Lv, X., Yan, T., et al. (2020) · Journal of Biomaterials Applications · doi:10.1177/0885328220914408 · Cited by 2
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Nakamoto, K., Kageyama, T., Hosoi, S., Matsunaga, T., & Lee, S. (2022) · Sensors and Materials · doi:10.18494/sam3965 · Cited by 2
Chuang, H.-S., Wang, W., & Chen, C. (2024) · Bioanalysis · doi:10.1007/978-981-97-6540-9_6 · Cited by 1
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Lima, R. A., Minas, G. M. H., & Catarino, S. O. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-825-7 · Cited by 1
Microfluidic devices for cell separation and sample concentration
Liu, N. (2018) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/73351
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Iliescu, C., Tresset, G., Ni, M., & Mrculescu, C. (2018) · IEEE International Nanoelectronics Conference · doi:10.1109/inec.2018.8441913
Chuang, H.-S., Wang, W., & Chen, C. (2019) · Bioanalysis · doi:10.1007/978-981-13-6229-3_6
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Smiljanić, M., Radjenović, B., Lazić, Ž., Radmilović-Radjenović, M., Rafajilović, M. R., Cvetanović, K., Milinković, E., & Filipović, A. (2021) · Hemijska industrija · doi:10.2298/hemind200807005s
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Dey, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818154-6.00002-0
Pham, H. T., & Pham, V.-S. (2026) · Physics of Fluids · doi:10.1063/5.0298968
Varol, T. Ö., & Varol, M. (2026) · Annals of Biomedical Engineering · doi:10.1007/s10439-026-04396-z
Metadata
- Authors
- Jiang, J., Zhao, H., Shu, W., Tian, J., Huang, Y., Song, Y., Wang, R., Li, E., Slamon, D., Hou, D., Du, X., Zhang, L., Chen, Y., & Wang, Q.
- Affiliations
- Dalian Medical University (CN)
- Chinese Academy of Sciences (CN)
- Dalian Maritime University (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
- University of California, Los Angeles (US)
- Corresponding author
- Zhang, Lichuan
- Chen, Yan
- Wang, Qi
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-02-15
- Volume
- 7
- Issue
- 1
- Pages
- 42612-42612
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5309797
- OpenAlex
- W2588287202
- Cited by
- 66
- References
- 49
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 12 · 2020: 7 · 2019: 15 · 2018: 9 · 2017: 2
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (863 Program, 81502702, #91129733, 81330060)
- National High-tech Research and Development Program (2015AA020409)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- circulating tumor cells, microfluidics, deterministic lateral displacement, CD45, rat tail collagen, CTC capture, metastatic cancer, CellSearch comparison, sample volume reduction
- MeSH terms
- Aged, Aged, 80 and over, Cell Survival, Combined Modality Therapy, Female, Fluorescent Antibody Technique, Humans, Male, Microscopy, Fluorescence, Middle Aged, Neoplastic Cells, Circulating, Neoplasm Staging, Neoplasms, Biomarkers, Case-Control Studies, Cell Line, Tumor, Microfluidic Analytical Techniques, Lab-On-A-Chip Devices
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