Gut: An underestimated target organ for Aluminum
Abstract
Since World War II, several factors such as an impressive industrial growth, an enhanced environmental bioavailability and intensified food consumption have contributed to a significant amplification of human exposure to aluminum. Aluminum is particularly present in food, beverages, some drugs and airbone dust. In our food, aluminum is superimposed via additives and cooking utensils. Therefore, the tolerable intake of aluminum is exceeded for a significant part of the world population, especially in children who are more vulnerable to toxic effects of pollutants than adults. Faced with this oral aluminum influx, intestinal tract is an essential barrier, especially as 38% of ingested aluminum accumulates at the intestinal mucosa. Although still poorly documented to date, the impact of oral exposure to aluminum in conditions relevant to real human exposure appears to be deleterious for gut homeostasis. Aluminum ingestion affects the regulation of the permeability, the microflora and the immune function of intestine. Nowadays, several arguments are consistent with an involvement of aluminum as an environmental risk factor for inflammatory bowel diseases.
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Oral intake of Al may affect the intestinal microbiota, permeability and immune response, which influence local inflammatory conditions.
“Oral intake of Al may affect the intestinal microbiota, permeability and immune response which influence the local inflammatory conditions (Vignal et al., 2016).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Vignal et al., 2016
Cites
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256 · see citing works
Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
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Hold, G. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i5.1192 · Cited by 365 · see citing works
Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice
Pineton de Chambrun, G., Body-Malapel, M., Frey-Wagner, I., Djouina, M., Deknuydt, F., Atrott, K., Esquerre, N., Altare, F., Neut, C., Arrieta, M. C., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2013.78 · Cited by 108 · see citing works
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Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395 · see citing works
“Oral intake of Al may affect the intestinal microbiota, permeability and immune response which influence the local inflammatory conditions (Vignal et al., 2016).”
Background
- Authors
- Vignal, C., Desreumaux, P., & Body-Malapel, M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Vignal, C.
- Venue
- Morphologie
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 100
- Issue
- 329
- Pages
- 75-84
- ISSN
- 0376-6160 (ISSN-L)
- 1286-0115
- OpenAlex
- W2296123019
- Cited by
- 50
- References
- 4
- Citations by year
- 2026: 3 · 2025: 5 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 11 · 2018: 4 · 2017: 2 · 2016: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Morphologie (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- LillOA (Université de Lille (University Of Lille)) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- aluminum, intestine, intestinal mucosa, intestinal permeability, gut microbiota, intestinal immunity, inflammatory bowel disease, aluminum additive, tolerable intake, children, intestinal homeostasis, environmental exposure, food contamination, cooking utensils, airborne dust, air pollution, industrial pollution, intestinal inflammation
- MeSH terms
- Gastrointestinal Microbiome, Adult, Animals, Beverages, Biological Availability, Child, Cooking and Eating Utensils, Crohn Disease, Dust, Eating, Environmental Exposure, Environmental Pollutants, Food, Homeostasis, Horses, Humans, Intestinal Mucosa, Risk Factors, Inflammatory Bowel Diseases, Incidence, Aluminum Compounds, Genome-Wide Association Study
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