The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
DNA methylation in development and human disease
Open accessAbstract
DNA methylation is a heritable and stable epigenetic mark associated with transcriptional repression. Changes in the patterns and levels of global and regional DNA methylation regulate development and contribute directly to disease states such as cancer. Recent findings provide intriguing insights into the epigenetic crosstalk between DNA methylation, histone modifications, and small interfering RNAs in the control of cell development and carcinogenesis. In this review, we summarize the recent studies in DNA methylation primarily focusing on the interplay between different epigenetic modifications and their potential role in gene silencing in development and disease. Although the molecular mechanisms involved in the epigenetic crosstalk are not fully understood, unraveling their precise regulation is important not only for understanding the underpinnings of cellular development and cancer, but also for the design of clinically relevant and efficient therapeutics using stem cells and anticancer drugs that target tumor initiating cells.
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1 retracted
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In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
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EUKARYOTIC CYTOSINE METHYLTRANSFERASES
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Cited by
DNA Methylation: Superior or Subordinate in the Epigenetic Hierarchy?
Jin, B., Li, Y., & Robertson, K. D. (2011) · Genes & Cancer · doi:10.1177/1947601910393957 · Cited by 817
Self-citationEpigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Lu, Y., Chan, Y.-T., Tan, H.-Y., Li, S., Wang, N., & Feng, Y. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01197-3 · Cited by 499
McCartney, D. L., Walker, R. M., Morris, S. W., McIntosh, A. M., Porteous, D. J., & Evans, K. L. (2016) · Genomics Data · doi:10.1016/j.gdata.2016.05.012 · Cited by 388
Albrengues, J., Bertero, T., Grasset, E., Bonan, S., Maiel, M., Bourget, I., Philippe, C., Herraiz Serrano, C., Benamar, S., Croce, O., et al. (2015) · Nature Communications · doi:10.1038/ncomms10204 · Cited by 367
A twin approach to unraveling epigenetics
Bell, J. T., & Spector, T. D. (2011) · Trends in Genetics · doi:10.1016/j.tig.2010.12.005 · Cited by 353
Metadata
- Authors
- Gopalakrishnan, S., Van Emburgh, B. O., & Robertson, K. D.
- Venue
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 647
- Issue
- 1-2
- Pages
- 30-38
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W1989573122
- Cited by
- 266
- References
- 73
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Gopalakrishnan, S., Van Emburgh, B. O., & Robertson, K. D. (2008). DNA methylation in development and human disease. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. https://doi.org/10.1016/j.mrfmmm.2008.08.006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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