The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
DNA Methylation: Superior or Subordinate in the Epigenetic Hierarchy?
Open accessAbstract
Epigenetic modifications are heritable changes in gene expression not encoded by the DNA sequence. In the past decade, great strides have been made in characterizing epigenetic changes during normal development and in disease states like cancer. However, the epigenetic landscape has grown increasingly complicated, encompassing DNA methylation, the histone code, noncoding RNA, and nucleosome positioning, along with DNA sequence. As a stable repressive mark, DNA methylation, catalyzed by the DNA methyltransferases (DNMTs), is regarded as a key player in epigenetic silencing of transcription. DNA methylation may coordinately regulate the chromatin status via the interaction of DNMTs with other modifications and with components of the machinery mediating those marks. In this review, we will comprehensively examine the current understanding of the connections between DNA methylation and other epigenetic marks and discuss molecular mechanisms of transcriptional repression in development and in carcinogenesis.
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2 retracted
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Cited by
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059
The roles of DNA, RNA and histone methylation in ageing and cancer
Michalak, E. M., Burr, M. L., Bannister, A. J., & Dawson, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0143-1 · Cited by 549
Clare, C. E., Brassington, A. H., Kwong, W. Y., & Sinclair, K. D. (2019) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-020518-115206 · Cited by 394
Day, K., Waite, L. L., Thalacker-Mercer, A., West, A., Bamman, M. M., Brooks, J. D., Myers, R. M., & Absher, D. (2013) · Genome Biology · doi:10.1186/gb-2013-14-9-r102 · Cited by 364
H3K27 methylation: a promiscuous repressive chromatin mark
Wiles, E. T., & Selker, E. U. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.11.001 · Cited by 331
Metadata
- Authors
- Jin, B., Li, Y., & Robertson, K. D.
- Venue
- Genes & Cancer
- Publisher
- SAGE Publications
- Published
- 2011-01-31
- Volume
- 2
- Issue
- 6
- Pages
- 607-617
- ISSN
- 1947-6019 (ISSN-L)
- 1947-6027
- OpenAlex
- W2158998217
- Cited by
- 817
- References
- 115
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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