A twin approach to unraveling epigenetics

Finding the missing heritability of complex diseases

Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336 · see citing works

DNA methylation patterns and epigenetic memory

Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124 · see citing works

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325 · see citing works

Capturing Chromosome Conformation

Dekker, J., Rippe, K., Dekker, M., & Kleckner, N. (2002) · Science · doi:10.1126/science.1067799 · Cited by 3,652 · see citing works

Epigenetic differences arise during the lifetime of monozygotic twins

Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602 · see citing works

Fetal origins of coronary heart disease

Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570 · see citing works

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700 · see citing works

Genomic DNA methylation: the mark and its mediators.

Klose, R. J., & Bird, A. P. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.12.008 · Cited by 2,501 · see citing works

Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies

Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356 · see citing works

Linking DNA methylation and histone modification: patterns and paradigms

Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267 · see citing works

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

Irizarry, R. A., Ladd-Acosta, C., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.298 · Cited by 2,177 · see citing works

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

Goll, M. G., & Bestor, T. H. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.010904.153721 · Cited by 2,066 · see citing works

The Role of DNA Methylation in Mammalian Epigenetics

Jones, P. A., & Takai, D. (2001) · Science · doi:10.1126/science.1063852 · Cited by 2,063 · see citing works

DNA Modification Mechanisms and Gene Activity During Development

Holliday, R., & Pugh, J. E. (1975) · Science · doi:10.1126/science.187.4173.226 · Cited by 1,973 · see citing works

Stability and flexibility of epigenetic gene regulation in mammalian development

Reik, W. (2007) · Nature · doi:10.1038/nature05918 · Cited by 1,963 · see citing works

Heritability in the genomics era — concepts and misconceptions

Visscher, P. M., Hill, W. G., & Wray, N. R. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2322 · Cited by 1,921 · see citing works

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

Weber, M., Davies, J. J., Wittig, D., Oakeley, E., Haase, M., Lam, W., & Schübeler, D. (2005) · Nature Genetics · doi:10.1038/ng1598 · Cited by 1,885 · see citing works

Phenotypic plasticity and the epigenetics of human disease

Feinberg, A. P. (2007) · Nature · doi:10.1038/nature05919 · Cited by 1,613 · see citing works

The power and the promise of DNA methylation markers

Laird, P. W. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1045 · Cited by 1,548 · see citing works

Direct detection of DNA methylation during single-molecule, real-time sequencing

Flusberg, B. A., Webster, D. R., Lee, J. H., Travers, K. J., Olivares, E. C., Clark, T. A., Korlach, J., & Turner, S. W. (2010) · Nature Methods · doi:10.1038/nmeth.1459 · Cited by 1,460 · see citing works

High-Resolution Mapping and Characterization of Open Chromatin across the Genome

Boyle, A. P., Davis, S., Shulha, H. P., Meltzer, P., Margulies, E. H., Weng, Z., Furey, T. S., & Crawford, G. E. (2008) · Cell · doi:10.1016/j.cell.2007.12.014 · Cited by 1,415 · see citing works

Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)

Simonis, M., Klous, P., Splinter, E., Moshkin, Y., Willemsen, R., de Wit, E., van Steensel, B., & de Laat, W. (2006) · Nature Genetics · doi:10.1038/ng1896 · Cited by 1,386 · see citing works

DNA methylation profiling of human chromosomes 6, 20 and 22

Eckhardt, F., Lewin, J., Cortese, R., Rakyan, V. K., Attwood, J., Burger, M., Burton, J. H., Cox, T. V., Davies, R., Down, T. A., et al. (2006) · Nature Genetics · doi:10.1038/ng1909 · Cited by 1,350 · see citing works

X inactivation, differentiation, and DNA methylation

Riggs, A. D. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000130315 · Cited by 1,343 · see citing works

Linkage strategies for genetically complex traits. I. Multilocus models.

RISCH, N. J. (1990) · PubMed · Cited by 1,315 · see citing works

How Are Alkynes Scrambled?

Bunz, U. H. F. (2005) · Science · doi:10.1126/science.1111098 · Cited by 1,252 · see citing works

Inherited epigenetic variation — revisiting soft inheritance

Richards, E. J. (2006) · Nature reviews genetics · doi:10.1038/nrg1834 · Cited by 1,200 · see citing works

Chromosome Conformation Capture Carbon Copy (5C): A massively parallel solution for mapping interactions between genomic elementsPreprint

Dostie, J., Richmond, T., Arnaout, R., Selzer, R. R., Lee, W. L., Honan, T., Rubio, E. D., Krumm, A., Lamb, J., Nusbaum, C., et al. (2006) · Genome Research · doi:10.1101/gr.5571506 · Cited by 1,182 · see citing works

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

Doi, A., Park, I., Wen, B., Murakami, P. N., Aryee, M. J., Irizarry, R. A., Herb, B. R., Ladd‐Acosta, C., Rho, J., Loewer, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.471 · Cited by 1,173 · see citing works

Charting histone modifications and the functional organization of mammalian genomes

Zhou, V. W., Goren, A., & Bernstein, B. E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2905 · Cited by 1,147 · see citing works

Epigenetic mechanisms of gene regulation

Russo, V. E. A., Martienssen, R. A., & Riggs, A. D. (1996) · Medical Entomology and Zoology · Cited by 1,088 · see citing works

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

Ball, M. P., Li, J. B., Gao, Y., Lee, J., LeProust, E. M., Park, I., Xie, B., Daley, G. Q., & Church, G. M. (2009) · Nature Biotechnology · doi:10.1038/nbt.1533 · Cited by 1,087 · see citing works

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

Ramsahoye, B., Biniszkiewicz, D., Lyko, F., Clark, V. H., Bird, A., & Jaenisch, R. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.10.5237 · Cited by 1,018 · see citing works

Linkage strategies for genetically complex traits. II. The power of affected relative pairs.

RISCH, N. J. (1990) · PubMed · Cited by 868 · see citing works

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

Teschendorff, A. E., Menon, U., Gentry-Maharaj, A., Ramus, S. J., Weisenberger, D. J., Shen, H., Campan, M., Noushmehr, H., Bell, C. G., Maxwell, A. P., et al. (2010) · Genome Research · doi:10.1101/gr.103606.109 · Cited by 855 · see citing works

Assessing the Impact of Transgenerational Epigenetic Variation on Complex Traits

Johannes, F., Porcher, E., Teixeira, F. K., Saliba-Colombani, V., Simon, M., Agier, N., Bulski, A., Albuisson, J., Heredia, F., Audigier, P., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000530 · Cited by 814 · see citing works

Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain

Gibbs, J. R., van der Brug, M. P., Hernandez, D. G., Traynor, B. J., Nalls, M. A., Lai, S.-L., Arepalli, S., Dillman, A., Rafferty, I. P., Troncoso, J., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000952 · Cited by 769 · see citing works

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domainsPreprint

Rakyan, V. K., Down, T. A., Maslau, S., Andrew, T., Yang, T.-P., Beyan, H., Whittaker, P., McCann, O. T., Finer, S., Valdes, A. M., et al. (2010) · Genome Research · doi:10.1101/gr.103101.109 · Cited by 750 · see citing works

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications

Harris, R. A., Wang, T., Coarfa, C., Nagarajan, R. P., Hong, C., Downey, S. L., Johnson, B., Fouse, S. D., Delaney, A. D., Zhao, Y., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1682 · Cited by 713 · see citing works

Intra-individual Change Over Time in DNA Methylation With Familial Clustering

Bjornsson, H. T. (2008) · JAMA · doi:10.1001/jama.299.24.2877 · Cited by 702 · see citing works

Genetic influences on osteoarthritis in women: a twin study

Spector, T. D., Cicuttini, F., Baker, J., Loughlin, J. A., & Hart, D. J. (1996) · BMJ · doi:10.1136/bmj.312.7036.940 · Cited by 690 · see citing works

Epigenetics as a unifying principle in the aetiology of complex traits and diseases

Petronis, A. (2010) · Nature · doi:10.1038/nature09230 · Cited by 682 · see citing works

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosusPreprint

Javierre, B. M., Fernández, A. F., Richter, J., Al‐Shahrour, F., Martín-Subero, J. I., Rodríguez‐Ubreva, J., Berdasco, M., Fraga, M. F., OʼHanlon, T. P., Rider, L. G., et al. (2009) · Genome Research · doi:10.1101/gr.100289.109 · Cited by 669 · see citing works

DNA methylation profiles in monozygotic and dizygotic twins

Kaminsky, Z. A., Tang, T., Wang, S.-C., Ptak, C., Oh, G., Wong, A. H. C., Feldcamp, L. A., Virtanen, C., Halfvarson, J., Tysk, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.286 · Cited by 662 · see citing works

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

Down, T. A., Rakyan, V. K., Turner, D., Flicek, P., Li, H., Kulesha, E., Gräf, S., Johnson, N., Herrero, J., Tomazou, E. M., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1414 · Cited by 651 · see citing works

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis

Feldman, N., Gerson, A., Fang, J., Li, E., Zhang, Y., Shinkai, Y., Cedar, H., & Bergman, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1353 · Cited by 651 · see citing works

DNA methylation and histone modifications: teaming up to silence genes

Fuks, F. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.08.002 · Cited by 643 · see citing works

Transgenerational inheritance of epigenetic states at the murine Axin Fu allele occurs after maternal and paternal transmission

Rakyan, V. K., Chong, S., Blewitt, M. E., Cuthbert, P. C., Morgan, H. D., Luu, K. V. K., & Whitelaw, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436776100 · Cited by 642 · see citing works

Variation in Transcription Factor Binding Among Humans

Kasowski, M. M., Grubert, F., Heffelfinger, C., Hariharan, M., Asabere, A., Waszak, S., Habegger, L., Rozowsky, J., Shi, M.-Y., Urban, A., et al. (2010) · Science · doi:10.1126/science.1183621 · Cited by 625 · see citing works

Quantitative comparison of genome-wide DNA methylation mapping technologies

Bock, C., Tomazou, E. M., Brinkman, A. B., Müller, F., Simmer, F., Gu, H., Jäger, N., Gnirke, A., Stunnenberg, H. G., & Meissner, A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1681 · Cited by 587 · see citing works

Transgenerational Epigenetic Effects

Youngson, N. A., & Whitelaw, E. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164445 · Cited by 575 · see citing works

W. H. Fox Talbot and the history of photography

Gernsheim, H. (1977) · Endeavour · doi:10.1016/0160-9327(77)90005-9 · Cited by 565 · see citing works

Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops

Murrell, A., Heeson, S., & Reik, W. (2004) · Nature Genetics · doi:10.1038/ng1402 · Cited by 556 · see citing works

A map of open chromatin in human pancreatic islets

Gaulton, K. J., Nammo, T., Pasquali, L., Simon, J. M., Giresi, P. G., Fogarty, M. P., Panhuis, T. M., Mieczkowski, P. A., Secchi, A., Bosco, D., et al. (2010) · Nature Genetics · doi:10.1038/ng.530 · Cited by 530 · see citing works

A Population-Based Twin Study of Lifetime Major Depression in Men and Women

Kendler, K. S., & Prescott, C. A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.1.39 · Cited by 512 · see citing works

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

Shen, S., Sandoval, J., Swiss, V. A., Li, J., Dupree, J. L., Franklin, R. J. M., & Casaccia‐Bonnefil, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2172 · Cited by 486 · see citing works

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

Baranzini, S. E., Mudge, J., van Velkinburgh, J. C., Khankhanian, P., Khrebtukova, I., Miller, N. A., Zhang, L., Farmer, A. D., Bell, C. J., Kim, R. W., et al. (2010) · Nature · doi:10.1038/nature08990 · Cited by 476 · see citing works

Germline epimutation of MLH1 in individuals with multiple cancers

Suter, C. M., Martin, D. I. K., & Ward, R. L. (2004) · Nature Genetics · doi:10.1038/ng1342 · Cited by 475 · see citing works

DNA methylation and chromatin – unraveling the tangled web

Robertson, K. D. (2002) · Oncogene · doi:10.1038/sj.onc.1205609 · Cited by 471 · see citing works

Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation

Kerkel, K., SPADOLA, A. C., Yuan, E., Kosek, J., Jiang, L., Hod, E. A., Li, K., Murty, V. V. V. S., Schupf, N., Vilain, E. J. N., et al. (2008) · Nature Genetics · doi:10.1038/ng.174 · Cited by 437 · see citing works

Cigarette smoking increases the risk of rheumatoid arthritis: Results from a nationwide study of disease‐discordant twins

Silman, A. J., Newman, J., & MacGregor, A. J. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390504 · Cited by 394 · see citing works

The Bone Density of Female Twins Discordant for Tobacco Use

Hopper, J. L., & Seeman, E. (1994) · New England Journal of Medicine · doi:10.1056/nejm199402103300603 · Cited by 391 · see citing works

Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain

Zhang, D., Cheng, L., Badner, J. A., Chen, C., Chen, Q., Luo, W., Craig, D. W., Redman, M., Gershon, E. S., & Liu, C. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.02.005 · Cited by 388 · see citing works

Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs.

RISCH, N. J. (1990) · PubMed · Cited by 387 · see citing works

Finding the fifth base: Genome-wide sequencing of cytosine methylationPreprint

Lister, R., & Ecker, J. R. (2009) · Genome Research · doi:10.1101/gr.083451.108 · Cited by 377 · see citing works

The Relationship of DNA Methylation with Age, Gender and Genotype in Twins and Healthy Controls

Boks, M. P., Derks, E. M., Weisenberger, D. J., Strengman, E., Janson, E., Sommer, I. E., Kahn, R. S., & Ophoff, R. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006767 · Cited by 369 · see citing works

Genome-wide association studies: potential next steps on a genetic journey

McCarthy, M. I., & Hirschhorn, J. N. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn289 · Cited by 354 · see citing works

Epigenetic Inheritance and the Missing Heritability Problem

Slatkin, M. (2009) · Genetics · doi:10.1534/genetics.109.102798 · Cited by 337 · see citing works

Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome

Weksberg, R. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.11.1317 · Cited by 328 · see citing works

Epigenetics and Assisted Reproductive Technology: A Call for Investigation

Niemitz, E. L., & Feinberg, A. P. (2004) · The American Journal of Human Genetics · doi:10.1086/382897 · Cited by 325 · see citing works

A longitudinal study of epigenetic variation in twins

Wong, C. C. Y., Caspi, A., Williams, B. S., Craig, I., Houts, R., Ambler, A. P., Moffitt, T. E., & Mill, J. S. (2010) · Epigenetics · doi:10.4161/epi.5.6.12226 · Cited by 320 · see citing works

Monozygotic Twins Exhibit Numerous Epigenetic Differences: Clues to Twin Discordance?

Petronis, A., Gottesman, I. I., Kan, P., Kennedy, J. L., Basile, V. S., Paterson, A. D., & Popendikytė, V. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006988 · Cited by 312 · see citing works

DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome

Ollikainen, M., Smith, K. R., Joo, E. J.-H., Ng, H. K., Andronikos, R. H., Novakovic, B., Aziz, N. K. A., Carlin, J. B., Morley, R., Saffery, R., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq336 · Cited by 312 · see citing works

Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology

Talens, R. P., Boomsma, D. I., Tobi, E. W., Kremer, D., Jukema, J. W., Willemsen, G. A. H. M., Putter, H., Slagboom, P. E., & Heijmans, B. T. (2010) · The FASEB Journal · doi:10.1096/fj.09-150490 · Cited by 312 · see citing works

Heritable Individual-Specific and Allele-Specific Chromatin Signatures in Humans

McDaniell, R., Lee, B.-K., Song, L., Liu, Z., Boyle, A. P., Erdos, M. R., Scott, L. J., Morken, M. A., Kucera, K. S., Battenhouse, A., et al. (2010) · Science · doi:10.1126/science.1184655 · Cited by 308 · see citing works

The effects of social status on biological aging as measured by white‐blood‐cell telomere length

Cherkas, L. F., Aviv, A., Valdes, A. M., Hunkin, J., Gardner, J. P., Surdulescu, G. L., Kimura, M., & Spector, T. D. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00222.x · Cited by 306 · see citing works

Microarray-based DNA methylation profiling: technology and applications

Schumacher, A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj461 · Cited by 295 · see citing works

Epigenetics: An overview

Holliday, R. (1994) · Developmental Genetics · doi:10.1002/dvg.1020150602 · Cited by 272 · see citing works

DNA methylation in development and human disease

Gopalakrishnan, S., Emburgh, B. O. V., & Robertson, K. D. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.08.006 · Cited by 267 · see citing works

Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

Pfeifer, G. P., Steigerwald, S. D., Hansen, R. S., Gartler, S. M., & Riggs, A. D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8252 · Cited by 255 · see citing works

Allelic Skewing of DNA Methylation Is Widespread across the Genome

Schalkwyk, L. C., Meaburn, E. L., Smith, R. G., Dempster, E. L., Jeffries, A. R., Davies, M. N., Plomin, R. J., & Mill, J. S. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.01.014 · Cited by 244 · see citing works

A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals?

Gärtner, K. (1990) · Laboratory Animals · doi:10.1258/002367790780890347 · Cited by 241 · see citing works

Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus

Heijmans, B. T., Kremer, D., Tobi, E. W., Boomsma, D. I., & Slagboom, P. E. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm010 · Cited by 238 · see citing works

Epigenome dynamics: a quantitative genetics perspective

Johannes, F., Colot, V., & Jansen, R. (2008) · Nature reviews genetics · doi:10.1038/nrg2467 · Cited by 230 · see citing works

Assisted Reproductive Technology Surveillance - United States, 2001

Wright, V. C., Schieve, L. A., Reynolds, M. A., Jeng, G. T., & Kissin, D. (2004) · PsycEXTRA Dataset · doi:10.1037/e566402006-001 · Cited by 226 · see citing works

Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis

Badger, A. M., Griswold, D. E., Kapadia, R. D., Blake, S. M., Swift, B. A., Hoffman, S. J., Stroup, G. B., Webb, E. F., Rieman, D. J., Gowen, M., et al. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1 · Cited by 213 · see citing works

Allele-specific gene expression uncovered

Knight, J. C. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.01.001 · Cited by 211 · see citing works

Mapping accessible chromatin regions using Sono-Seq

Auerbach, R. K., Euskirchen, G. M., Rozowsky, J. S., Lamarre-Vincent, N., Moqtaderi, Z., Lefrançois, P., Struhl, K., Gerstein, M., & Snyder, M. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905443106 · Cited by 205 · see citing works

Obesity Is an Important Determinant of Baseline Serum C-Reactive Protein Concentration in Monozygotic Twins, Independent of Genetic Influences

Greenfield, J. R., Samaras, K., Jenkins, A. B., Kelly, P. J., Spector, T. D., Gallimore, J. R., Pepys, M. B., & Campbell, L. V. (2004) · Circulation · doi:10.1161/01.cir.0000130640.77501.79 · Cited by 189 · see citing works

Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins

Kuratomi, G., Iwamoto, K., Bundo, M., Kusumi, I., Kato, N., Iwata, N., Ozaki, N., & Kato, T. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002001 · Cited by 188 · see citing works

Transposable elements in the mammalian germline: a comfortable niche or a deadly trap?

Zamudio, N., & Bourc’his, D. (2010) · Heredity · doi:10.1038/hdy.2010.53 · Cited by 179 · see citing works

DNA methylation stabilizes X chromosome inactivation in eutherians but not in marsupials: evidence for multistep maintenance of mammalian X dosage compensation.

Kaslow, D. C., & Migeon, B. R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.17.6210 · Cited by 173 · see citing works

Advances in Twin and Sib-Pair Analysis.

Cherny, S. S. (2001) · The American Journal of Human Genetics · doi:10.1086/322935 · Cited by 166 · see citing works

An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype

Murrell, A. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddh013 · Cited by 160 · see citing works

Twins

MacGregor, A. J., Snieder, H., Schork, N. J., & Spector, T. D. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01946-0 · Cited by 154 · see citing works

Assisted reproductive technology surveillance--United States, 2000.

Wright, V. C., Schieve, L. A., Reynolds, M. A., & Jeng, G. T. (2003) · PubMed · Cited by 136 · see citing works

Increased DNA Methylation at the AXIN1 Gene in a Monozygotic Twin from a Pair Discordant for a Caudal Duplication Anomaly

Oates, N., van Vliet, J., Duffy, D. L., Kroes, H. Y., Martin, N. G., Boomsma, D. I., Campbell, M., Coulthard, M. G., Whitelaw, E., & Chong, S. (2006) · The American Journal of Human Genetics · doi:10.1086/505031 · Cited by 135 · see citing works

Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol‐O‐methyltransferase (COMT) gene

Mill, J. S., Dempster, E. L., Caspi, A., Williams, B. S., Moffitt, T. E., & Craig, I. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30316 · Cited by 134 · see citing works

Atopic disease and immunoglobulin E in twins reared apart and together.

Hanson, B., McGue, M., Roitman-Johnson, B., Segal, N. L., Bouchard, T. J., & Blumenthal, M. N. (1991) · Europe PMC (PubMed Central) · Cited by 126 · see citing works

A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformationsPreprint

Tiwari, V. K., Cope, L., McGarvey, K. M., Ohm, J. E., & Baylin, S. B. (2008) · Genome Research · doi:10.1101/gr.073452.107 · Cited by 122 · see citing works

ADVANCES IN TWIN AND SIB-PAIR ANALYSIS

Spector, T. D., Snieder, H., MacGregor, A. J., Strachan, D. P., Kaprio, J. A., Verkasalo, P. K., & Koskenvuo, M. (2004) · Cited by 109 · see citing works

Genetics of osteoporosis

Ralston, S. H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05317.x · Cited by 89 · see citing works

A population-epigenetic model to infer site-specific methylation rates from double-stranded DNA methylation patterns

Genereux, D. P., Miner, B. E., Bergstrom, C. T., & Laird, C. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502036102 · Cited by 85 · see citing works

Imprinting of Genes and the Barker Hypothesis

Young, L. E. (2001) · Twin Research · doi:10.1375/1369052012632 · Cited by 84 · see citing works

The effect of moderate alcohol consumption on bone mineral density: a study of female twins

Williams, F. M. K., Cherkas, L. F., Spector, T. D., & MacGregor, A. J. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.022269 · Cited by 83 · see citing works

Epigenetics of Personality Traits: An Illustrative Study of Identical Twins Discordant for Risk-Taking Behavior

Kaminsky, Z. A., Petronis, A., Wang, S.-C., Levine, B., Ghaffar, O., Floden, D. P., & Feinstein, A. (2008) · Twin Research and Human Genetics · doi:10.1375/twin.11.1.1 · Cited by 82 · see citing works

Is the similarity of monozygotic twins due to genetic factors alone?

Gärtner, K., & Baunack, E. (1981) · Nature · doi:10.1038/292646a0 · Cited by 64 · see citing works

Assessment of mechanism of acquired skewed X inactivation by analysis of twins

Vickers, M. A., McLeod, E., Spector, T. D., & Wilson, I. (2001) · Blood · doi:10.1182/blood.v97.5.1274 · Cited by 61 · see citing works

Outsourced Teleradiology Imaging Services: An Analysis of Discordant Interpretation in 124,870 Cases

Wong, W. S., Roubal, I., Jackson, D., et al. (2005) · Journal of the American College of Radiology · doi:10.1016/j.jacr.2004.10.013 · Cited by 59 · see citing works

Methylated DNA Immunoprecipitation

Thu, K. L., Vucic, E. A., Kennett, J. Y., Heryet, C., Brown, C. J., Lam, W. L., & Wilson, I. M. (2009) · Journal of Visualized Experiments · doi:10.3791/935 · Cited by 51 · see citing works

54th Annual Meeting of the American Society of Human Genetics

King, K. Y., Sheikh, M. A., Cuthbert, A. P., Fisher, S. A., Onnie, C. M., Mirza, M., Sanderson, J. D., Forbes, A. C., Mansfield, J., Lewis, C. M., et al. (2004) · Cited by 43 · see citing works

Methylation analysis by DNA immunoprecipitation

Thu, K. L., Pikor, L. A., Kennett, J. Y., Alvarez, C. E., & Lam, W. L. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.22009 · Cited by 30 · see citing works

Improved transplantation outcome by epigenetic changes

Schildberg, F. A., Hagmann, C. A., Böhnert, V., & Tolba, R. H. (2010) · Transplant Immunology · doi:10.1016/j.trim.2010.05.001 · Cited by 14 · see citing works

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

Brodin, P., Jojic, V., Gao, T., Bhattacharya, S., Angel, C. J. L., Furman, D., Shen-Orr, S., Dekker, C. L., Swan, G. E., Butte, A. J., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.020 · Cited by 1,065 · see citing works

The contribution of environmental exposure to the etiology of autism spectrum disorder

Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509 · see citing works

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr416 · Cited by 460 · see citing works

The biodiversity hypothesis and allergic disease: world allergy organization position statement

Haahtela, T., Holgate, S., Pawankar, R., Akdis, C. A., Benjaponpitak, S., Caraballo, L., Demain, J., Portnoy, J., & von Hertzen, L. (2013) · World Allergy Organization Journal · doi:10.1186/1939-4551-6-3 · Cited by 426 · see citing works

Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits

Wong, C. C. Y., Meaburn, E. L., Ronald, A., Price, T. S., Jeffries, A. R., Schalkwyk, L. C., Plomin, R., & Mill, J. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.41 · Cited by 327 · see citing works

Environmentally induced epigenetic transgenerational inheritance of phenotype and disease

Guerrero-Bosagna, C., & Skinner, M. K. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.004 · Cited by 222 · see citing works

Fetal and postnatal metal dysregulation in autism

Arora, M., Reichenberg, A., Willfors, C., Austin, C., Gennings, C., Berggren, S., Lichtenstein, P., Anckarsäter, H., Tammimies, K., & Bölte, S. (2017) · Nature Communications · doi:10.1038/ncomms15493 · Cited by 169 · see citing works

Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies

Lowe, R., Gemma, C., Beyan, H., Hawa, M. I., Bazeos, A., Leslie, R. D., Montpetit, A., Rakyan, V. K., & Ramagopalan, S. V. (2013) · Epigenetics · doi:10.4161/epi.24362 · Cited by 160 · see citing works

Link between depression and cardiovascular diseases due to epigenomics and proteomics: Focus on energy metabolism

Kahl, K. G., Stapel, B., & Frieling, H. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.09.004 · Cited by 47 · see citing works

The influences of genetic and environmental factors on methylome-wide association studies for human diseases

Sun, Y. V. (2014) · Current Genetic Medicine Reports · doi:10.1007/s40142-014-0058-2 · Cited by 27 · see citing works

Elements of ‘missing heritability’

Marian, A. J. (2012) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328352707d · Cited by 67 · see citing works

Quantitative Genetics: Heritability Is Not Always Missing

Brookfield, J. F. Y. (2013) · Current Biology · doi:10.1016/j.cub.2013.02.040 · Cited by 11 · see citing works

Why the missing heritability might not be in the DNA

Bourrat, P., Lu, Q., & Jablonka, E. (2017) · BioEssays · doi:10.1002/bies.201700067 · Cited by 61 · see citing works

The mystery of missing heritability: Genetic interactions create phantom heritability

Zuk, O., Hechter, E., Sunyaev, S. R., & Lander, E. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119675109 · Cited by 1,542 · see citing works

Inferring the nature of missing heritability in human traitsPreprint

López‐Cortegano, E., & Caballero, A. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/373290 · Cited by 1 · see citing works