Alterations of the microRNA network cause neurodegenerative disease

Hébert, Sébastien S.; De Strooper, Bart

doi:10.1016/j.tins.2008.12.003

Cited by 452MicroRNA in disease regulationNeuroinflammation and Neurodegeneration MechanismsGenetics and Neurodevelopmental Disorders

Alterations of the microRNA network cause neurodegenerative disease

Hébert, Sébastien S., De Strooper, Bart·2009·Trends in Neurosciences

DOI 10.1016/j.tins.2008.12.003

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Abstract

Brain development crucially depends on the integrity of microRNA (miRNA) pathways, which function at the post-transcriptional level as a rheostat of the transcriptome and proteome of the cell. miRNAs are also involved in many other, more specific, aspects of neuronal function such as neurite outgrowth and synapse formation. Complete loss of miRNA expression in the brain leads to neurodegeneration in several animal models. Evidence from patient material is emerging that miRNA dysregulation could, indeed, contribute to neurodegenerative disorders. The translation of proteins previously implicated in familial forms of disease seems to be under control of miRNAs, and changes in miRNAs might explain how these proteins become affected in sporadic neurodegenerative disease. Thus, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributors to neurodegenerative disorder.

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Crossref · 10.1016/j.tins.2008.12.003

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In previous study, miR-106b significantly decreased APP levels in HeLa cervical cancer cell line.
“In previous study, miR-106b significantly decreased APP levels in HeLa cervical cancer cell line (Hebert et al., 2009).”
From miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression (2012) · cites this paper as Hebert et al., 2009
miR-106b levels were significantly decreased in brains of AD cases and AD mouse model.
“Interestingly, miR-106b levels were significantly decreased in brains of AD cases and AD mouse model (Hebert et al., 2009; Wang et al., 2011; Wang et al., 2009).”
From miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression (2012) · cites this paper as Hebert et al., 2009
APP is another miR-106b target gene.
“Most interestingly, APP is another miR-106b target gene.”
From miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression (2012) · cites this paper as Hebert et al., 2009

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The MicroRNA Spectrum in 12 Body Fluids
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MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer’s disease
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miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model
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Expansion of Intronic GGCCTG Hexanucleotide Repeat in NOP56 Causes SCA36, a Type of Spinocerebellar Ataxia Accompanied by Motor Neuron Involvement
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miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation
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Analytical aspects of microRNA in diagnostics: A review
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MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein
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MicroRNA assassins: factors that regulate the disappearance of miRNAs
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Tight junction modulation of the blood brain barrier: CNS delivery of small molecules
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The involvement of microRNAs in neurodegenerative diseases
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Non-coding RNAs with essential roles in neurodegenerative disorders
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Impaired neurosteroid synthesis in multiple sclerosis
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MicroRNAs as Effectors of Brain Function with Roles in Ischemia and Injury, Neuroprotection, and Neurodegeneration
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MicroRNA networks direct neuronal development and plasticity
Loohuis, N. F. M. O., Kos, A., Martens, G. J. M., van Bokhoven, H., Kasri, N. N., & Aschrafi, A. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0788-1 · Cited by 220 · see citing works
MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer’s disease
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Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β
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miRNA Expression Profile after Status Epilepticus and Hippocampal Neuroprotection by Targeting miR-132
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In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
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MicroRNA dysregulation in schizophrenia
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Neural stem cell differentiation into mature neurons: Mechanisms of regulation and biotechnological applications
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<scp>MiR</scp>‐124 Regulates Apoptosis and Autophagy Process in <scp>MPTP</scp> Model of <scp>P</scp>arkinson's Disease by Targeting to <scp>B</scp>im
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SeqBuster, a bioinformatic tool for the processing and analysis of small RNAs datasets, reveals ubiquitous miRNA modifications in human embryonic cells
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MicroRNAs in age‐related diseases
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The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)
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miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease
Wang, W., Wilfred, B. R., Madathil, S. K., Tang, G., Hu, Y., Dimayuga, J., Stromberg, A. J., Huang, Q., Saatman, K. E., & Nelson, P. T. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091202 · Cited by 181 · see citing works
MicroRNA dysregulation in psychiatric disease
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MicroRNAs: Master Regulators of Ethanol Abuse and Toxicity?
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miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression
Kim, J., Yoon, H., Ramírez, C. M., Lee, S.-M., Hoe, H.-S., Fernández-Hernando, C., & Kim, J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.010 · Cited by 173 · see citing works
MicroRNAs in Alzheimer's disease
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miRandola: Extracellular Circulating MicroRNAs Database
Russo, F., Bella, S. D., Nigita, G., Macca, V., Laganà, A., Giugno, R., Pulvirenti, A., & Ferro, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047786 · Cited by 166 · see citing works
Early miR-155 upregulation contributes to neuroinflammation in Alzheimer’s disease triple transgenic mouse model
Guedes, J. R., Custódia, C. M., Silva, R. J., de Almeida, L. P., Pedroso de Lima, M. C., & Cardoso, A. L. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu348 · Cited by 150 · see citing works
Circulating MicroRNA Is a Biomarker of Pediatric Crohn Disease
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Catalytic Self-Assembly of Quantum-Dot-Based MicroRNA Nanosensor Directed by Toehold-Mediated Strand Displacement Cascade
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Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-β
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The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer
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Context-dependent functions of specific microRNAs in neuronal development
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MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy
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Update on non-canonical microRNAs
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MicroRNA Dysregulation in the Spinal Cord following Traumatic Injury
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Genome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebellar ataxia pathogenesis
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Identification of blood serum micro‐RNAs associated with idiopathic and LRRK2 Parkinson's disease
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microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer’s disease triple transgenic mice
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Down-Regulation of miRNA-30a Alleviates Cerebral Ischemic Injury Through Enhancing Beclin 1-Mediated Autophagy
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MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis
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Epigenetic mechanisms in Alzheimer's disease: Implications for pathogenesis and therapy
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miRNAs and long noncoding RNAs as biomarkers in human diseases
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A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis
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Reduced Mature MicroRNA Levels in Association with Dicer Loss in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis
McKiernan, R. C., Jimenez-Mateos, E. M., Bray, I. M., Engel, T., Brennan, G. P., Sano, T., Michalak, Z., Moran, C., Delanty, N., Farrell, M. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035921 · Cited by 128 · see citing works
Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
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Clinical applications of microRNAs
Hydbring, P., & Badalian‐Very, G. (2013) · F1000Research · doi:10.12688/f1000research.2-136.v3 · Cited by 168 · see citing works
miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor
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Genetic markers for diagnosis and pathogenesis of Alzheimer's disease
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Molecular and cellular pathophysiology of preclinical Alzheimer’s disease
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The emerging role of microRNAs in multiple sclerosis
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miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro
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Authors: Hébert, S. S., & De Strooper, B.
Affiliations: Vlaams Instituut voor Biotechnologie (BE)
ORCID: Hébert, Sébastien S.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2009-04
Volume: 32
Issue: 4
Pages: 199-206
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2008.12.003
OpenAlex: W2041945875
Cited by: 452
References: 94
Citations by year: 2026: 11 · 2025: 9 · 2024: 10 · 2023: 16 · 2022: 18 · 2021: 17 · 2020: 26 · 2019: 26 · 2018: 26 · 2017: 19 · 2016: 37 · 2015: 38 · 2014: 26 · 2013: 39 · 2012: 33
FWCI: 2.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Lirias (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: microRNA, neurodegenerative diseases, microRNA dysregulation, post-transcriptional regulation, neuronal development, neurite outgrowth, synaptogenesis, familial neurodegenerative disease
MeSH terms: Animals, Humans, Models, Biological, Neurodegenerative Diseases, MicroRNAs, Gene Regulatory Networks

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Alterations of the microRNA network cause neurodegenerative disease

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