The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Telomeres and lifestyle factors: Roles in cellular aging.
Abstract
Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effects of genetic, environmental and lifestyle factors on aging and aging-related diseases. It is timely to 'take stock' of where this work has led the field. This review summarizes studies that have examined associations between lifestyle factors and telomere length and telomerase activity. In most of the studies described in this chapter, telomere length was measured in leukocytes (LTL) or peripheral blood mononuclear cells (PBMCs), taken from blood draws from the study subjects. Much of this chapter focuses on psychological stress, a widespread factor often intimately tied in with lifestyle or behavioral factors that in turn are related to risks of clinical diseases. Together, these findings suggest that cellular aging is linked to a range of influences, with an individual's life events and lifestyle parameters playing significant roles. Lastly, we propose possible biochemical mechanisms that mediate these associations and discuss future directions.
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“HIV-associated inflammation and/or exposure to nucleoside analogues have been associated with changes in these and other key biologic pathways (33–40).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [39]
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1 retracted
Cytokines modulate telomerase activity in a human multiple myeloma cell line.
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Accelerated telomere shortening in response to life stress
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Oxidative stress shortens telomeres
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Obesity, cigarette smoking, and telomere length in women
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Genetic determination of telomere size in humans: a twin study of three age groups.
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Hostile Marital Interactions, Proinflammatory Cytokine Production, and Wound Healing
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The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length
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Blackburn, E. H., Epel, E. S., & Lin, J. (2015) · Science · doi:10.1126/science.aab3389 · Cited by 1,596
Van den Bergh, B. R. H., van den Heuvel, M. I., Lahti, M., Braeken, M., de Rooij, S. R., Entringer, S., Hoyer, D., Roseboom, T., Räikkönen, K., King, S., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.003 · Cited by 1,181
Identification of seven loci affecting mean telomere length and their association with disease
CARDIoGRAM consortium, Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., et al. (2013) · Nature Genetics · doi:10.1038/ng.2528 · Cited by 933
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522
Stress and telomere biology: a lifespan perspective
Shalev, I., Entringer, S., Wadhwa, P. D., Wolkowitz, O. M., Puterman, E., Lin, J., & Epel, E. S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.010 · Cited by 400
Metadata
- Authors
- Lin, J., Epel, E., & Blackburn, E.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Lin, Jue
- Venue
- Mutation research. Fundamental and molecular mechanisms of mutagenesis
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 730
- Issue
- 1-2
- Pages
- 85-89
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W1993467061
- Cited by
- 251
- References
- 83
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 20 · 2019: 24 · 2018: 21 · 2017: 25 · 2016: 25 · 2015: 26 · 2014: 24 · 2013: 16 · 2012: 16
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- telomeres, telomere length, telomerase activity, cellular aging, lifestyle factors, psychological stress, leukocyte telomere length, peripheral blood mononuclear cells, age-related diseases, biochemical mechanisms
- MeSH terms
- Aging, Diet, Humans, Leukocytes, Life Style, Stress, Psychological, Temperament, Telomere, Cellular Senescence, Telomere Homeostasis
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