Cited by 251Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

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Telomeres and lifestyle factors: Roles in cellular aging.

Lin, Jue, Epel, Elissa, Blackburn, Elizabeth·2012·Mutation research. Fundamental and molecular mechanisms of mutagenesis

DOI 10.1016/j.mrfmmm.2011.08.003

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Abstract

Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effects of genetic, environmental and lifestyle factors on aging and aging-related diseases. It is timely to 'take stock' of where this work has led the field. This review summarizes studies that have examined associations between lifestyle factors and telomere length and telomerase activity. In most of the studies described in this chapter, telomere length was measured in leukocytes (LTL) or peripheral blood mononuclear cells (PBMCs), taken from blood draws from the study subjects. Much of this chapter focuses on psychological stress, a widespread factor often intimately tied in with lifestyle or behavioral factors that in turn are related to risks of clinical diseases. Together, these findings suggest that cellular aging is linked to a range of influences, with an individual's life events and lifestyle parameters playing significant roles. Lastly, we propose possible biochemical mechanisms that mediate these associations and discuss future directions.

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EDITORIAL
Wolkowitz, O. M., Epel, E. S., & Mellon, S. H. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701875601 · Cited by 24

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Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection
Blackburn, E. H., Epel, E. S., & Lin, J. (2015) · Science · doi:10.1126/science.aab3389 · Cited by 1,596
Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy
Van den Bergh, B. R. H., van den Heuvel, M. I., Lahti, M., Braeken, M., de Rooij, S. R., Entringer, S., Hoyer, D., Roseboom, T., Räikkönen, K., King, S., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.003 · Cited by 1,181
Identification of seven loci affecting mean telomere length and their association with disease
CARDIoGRAM consortium, Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., et al. (2013) · Nature Genetics · doi:10.1038/ng.2528 · Cited by 933
HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522
Stress and telomere biology: a lifespan perspective
Shalev, I., Entringer, S., Wadhwa, P. D., Wolkowitz, O. M., Puterman, E., Lin, J., & Epel, E. S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.010 · Cited by 400

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Authors: Lin, J., Epel, E., & Blackburn, E.
Affiliations: University of California, San Francisco (US)
Corresponding author: Lin, Jue
ORCID: Lin, Jue
Epel, Elissa
Blackburn, Elizabeth
Venue: Mutation research. Fundamental and molecular mechanisms of mutagenesis
Publisher: Elsevier BV
Published: 2012-02
Volume: 730
Issue: 1-2
Pages: 85-89
ISSN: 0027-5107 (ISSN-L)
1386-1964
DOI: 10.1016/j.mrfmmm.2011.08.003
OpenAlex: W1993467061
Cited by: 251
References: 83
Citations by year: 2026: 6 · 2025: 11 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 20 · 2019: 24 · 2018: 21 · 2017: 25 · 2016: 25 · 2015: 26 · 2014: 24 · 2013: 16 · 2012: 16
FWCI: 12.44
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: telomeres, telomere length, telomerase activity, cellular aging, lifestyle factors, psychological stress, leukocyte telomere length, peripheral blood mononuclear cells, age-related diseases, biochemical mechanisms
MeSH terms: Aging, Diet, Humans, Leukocytes, Life Style, Stress, Psychological, Temperament, Telomere, Cellular Senescence, Telomere Homeostasis

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Telomeres and lifestyle factors: Roles in cellular aging.

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