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Cited by 92Vitamin D Research StudiesDNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Does vitamin D protect against DNA damage?

Nair-Shalliker, Visalini, Armstrong, Bruce K., Fenech, Michael·2012·Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
DOI 10.1016/j.mrfmmm.2012.02.005
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Abstract

Vitamin D is a secosteroid best known for its role in maintaining bone and muscle health. Adequate levels of vitamin D may also be beneficial in maintaining DNA integrity. This role of vitamin D can be divided into a primary function that prevents damage from DNA and a secondary function that regulates the growth rate of cells. The potential for vitamin D to reduce oxidative damage to DNA in a human has been suggested by clinical trial where vitamin D supplementation reduced 8-hydroxy-2'-deoxyguanosine, a marker of oxidative damage, in colorectal epithelial crypt cells. Studies in animal models and in different cell types have also shown marked reduction in oxidative stress damage and chromosomal aberrations, prevention of telomere shortening and inhibition of telomerase activity following treatment with vitamin D. The secondary function of vitamin D in preventing DNA damage includes regulation of the poly-ADP-ribose polymerase activity in the DNA damage response pathway involved in the detection of DNA lesions. It is also able to regulate the cell cycle to prevent the propagation of damaged DNA, and to regulate apoptosis to promote cell death. Vitamin D may contribute to prevention of human colorectal cancer, though there is little evidence to suggest that prevention of DNA damage mediates this effect, if real. Very limited human data mean that the intake of vitamin D required to minimise DNA damage remains uncertain.

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Crossref · 10.1016/j.mrfmmm.2012.02.005

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  • Vitamin D can protect the genome from daily life insults such as oxidative stress and toxins.

    “Vitamin D regulates cell profilation and differentiation and can protect the genome from daily life insults such as oxidative stress and toxins (for a comprehensive review refer to [149]).”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [149]

  • Vitamin D regulates cell proliferation and differentiation.

    “Vitamin D regulates cell profilation and differentiation and can protect the genome from daily life insults such as oxidative stress and toxins (for a comprehensive review refer to [149]).”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [149]

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Authors
Nair-Shalliker, V., Armstrong, B. K., & Fenech, M.
Affiliations
  • The University of Sydney (AU)
  • Commonwealth Scientific and Industrial Research Organisation (AU)
ORCID
Venue
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Publisher
Elsevier BV
Published
2012-05
Volume
733
Issue
1-2
Pages
50-57
ISSN
  • 0027-5107 (ISSN-L)
  • 1386-1964
DOI
10.1016/j.mrfmmm.2012.02.005
OpenAlex
W2049755715
Cited by
92
References
89
Citations by year
2026: 4 · 2025: 7 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 5 · 2012: 3
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
  • PubMed (publishedVersion)
  • The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords
vitamin D, DNA damage, oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, colorectal cancer prevention, telomere shortening, telomerase inhibition, chromosomal abnormalities, poly(ADP-ribose) polymerase, DNA damage response, cell cycle regulation, apoptosis, vitamin D supplementation
MeSH terms
Cell Cycle, Cells, Cultured, DNA Damage, Humans, Nutritional Requirements, Skin, Ultraviolet Rays, Vitamin D, Oxidative Stress

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