Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: A randomized clinical trial
Open accessAbstract
The exact antineoplastic effects of calcium and vitamin D3 in the human colon are unclear. Animal and in vitro studies show that these two agents reduce oxidative stress; however, these findings have never been investigated in humans. To address this, we conducted a pilot, randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial to test the effects of calcium and vitamin D3 on a marker of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine (8-OH-dG), in the normal colorectal mucosa. Patients (N = 92) with at least one pathology-confirmed colorectal adenoma were treated with 2 g/d calcium and/or 800 IU/d vitamin D3 versus placebo over 6 months. Overall labeling and colorectal crypt distribution of 8-OH-dG in biopsies of normal-appearing rectal mucosa were detected by standardized automated immunohistochemistry and quantified by image analysis. After 6 months of treatment, 8-OH-dG labeling along the full lengths of colorectal crypts decreased by 22% (P = 0.15) and 25% (P = 0.10) in the calcium and vitamin D3 groups, respectively, but not in the calcium plus vitamin D3 group. The estimated treatment effects were strongest among participants with higher baseline colon crypt vitamin D receptor expression (P = 0.05). Overall, these preliminary results indicate that calcium and vitamin D3 may decrease oxidative DNA damage in the normal human colorectal mucosa, support the hypothesis that 8-OH-dG labeling in colorectal crypts is a treatable oxidative DNA damage biomarker of risk for colorectal neoplasms, and provide support for further investigation of calcium and vitamin D3 as chemopreventive agents against colorectal neoplasms. Cancer Epidemiol Biomarkers Prev; 19(1); 280–91
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Treatment with vitamin D increases Bax, a protein coding gene involved in apoptosis.
“Treatment with vitamin D has been shown to decrease 8—hydroxy–2—deoxyguanosin, a marker of endogenous oxidative damage to DNA [150], increase Bax, a protein coding gene involved in apoptosis [150], regulates poly-ADP-ribose polymerase activity in the DNA damage response pathway [151], stabilize chromosomal structure and prevent double strand breaks [152].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [150]
Treatment with vitamin D decreases 8-hydroxy-2-deoxyguanosin, a marker of endogenous oxidative damage to DNA.
“Treatment with vitamin D has been shown to decrease 8—hydroxy–2—deoxyguanosin, a marker of endogenous oxidative damage to DNA [150], increase Bax, a protein coding gene involved in apoptosis [150], regulates poly-ADP-ribose polymerase activity in the DNA damage response pathway [151], stabilize chromosomal structure and prevent double strand breaks [152].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [150]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709 · see citing works
Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
Lappe, J. M., Travers‐Gustafson, D., Davies, K. M., Recker, R. R., & Heaney, R. P. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1586 · Cited by 1,445 · see citing works
Kasai, H. (1997) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(97)00035-5 · Cited by 1,140 · see citing works
THE USE OF A SELF-ADMINISTERED QUESTIONNAIRE TO ASSESS DIET FOUR YEARS IN THE PAST
Willett, W. C., SAMPSON, L., Browne, M. L., Stampfer, M. J., ROSNER, B. A., Hennekens, C. H., & Speizer, F. E. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114780 · Cited by 801 · see citing works
Colon Cancer: A Review of the Epidemiology
Potter, J. D., Slattery, M. L., Bostick, R. M., & Gapstur, S. M. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036132 · Cited by 767 · see citing works
Self-citationEstrogen plus Progestin and Colorectal Cancer in Postmenopausal Women
Chlebowski, R. T., Wactawski‐Wende, J., Ritenbaugh, C., Hubbell, F. A., Ascensão, J. L., Rodabough, R. J., Rosenberg, C. A., Taylor, V. M., Harris, R. E., Chen, C., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032071 · Cited by 663 · see citing works
Bile acids as carcinogens in human gastrointestinal cancers
Bernstein, H., Bernstein, C., Payne, C. M., Dvorakova, K., & Garewal, H. (2005) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.08.001 · Cited by 611 · see citing works
Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms
Lamprecht, S. A., & Lipkin, M. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1144 · Cited by 584 · see citing works
(1997) · PubMed · Cited by 581 · see citing works
Colon Cancer and Dietary Fat, Phosphate, and Calcium: A Hypothesis
Newmark, H. L., Wargovich, M. J., & Bruce, W. R. (1984) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/72.6.1323 · Cited by 553 · see citing works
Dairy Foods, Calcium, and Colorectal Cancer: A Pooled Analysis of 10 Cohort Studies
Cho, E., Smith‐Warner, S. A., Spiegelman, D. L., Beeson, W. L., van den Brandt, P. A., Colditz, G. A., Folsom, A. R., Fraser, G. E., Freudenheim, J. L., Giovannucci, E. L., et al. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh185 · Cited by 511 · see citing works
Fink, G. (2000) · Cited by 502 · see citing works
Regulation of antioxidant enzymes 1
Harris, E. D. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.9.1612291 · Cited by 462 · see citing works
Endocrine functions of bone in mineral metabolism regulation
Quarles, L. D. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36479 · Cited by 459 · see citing works
Vitamin D, Calcium Supplementation, and Colorectal Adenomas: Results of a Randomized Trial
Grau, M. V. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg110 · Cited by 375 · see citing works
Calcium Intake and Risk of Colon Cancer in Women and Men
Wu, K. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.6.437 · Cited by 360 · see citing works
Free radicals and the etiology of colon cancer
Babbs, C. F. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90091-v · Cited by 328 · see citing works
Tishkoff, D. X., Nibbelink, K. A., Holmberg, K. H., Dandu, L., & Simpson, R. U. (2007) · Endocrinology · doi:10.1210/en.2007-0805 · Cited by 282 · see citing works
Oxidative stress in ulcerative colitis-associated carcinogenesis
Roessner, A., Kuester, D., Malfertheiner, P., & Schneider-Stock, R. (2008) · Pathology - Research and Practice · doi:10.1016/j.prp.2008.04.011 · Cited by 270 · see citing works
Cellular Mechanisms of Calcium and Vitamin D in the Inhibition of Colorectal Carcinogenesis
Lamprecht, S. A., & Lipkin, M. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb02729.x · Cited by 216 · see citing works
Pence, B. C., & Buddingh, F. (1988) · Carcinogenesis · doi:10.1093/carcin/9.1.187 · Cited by 214 · see citing works
Kállay, E. (2001) · Carcinogenesis · doi:10.1093/carcin/22.9.1429 · Cited by 176 · see citing works
Vitamin D, calcium, and vitamin D receptor polymorphism in colorectal adenomas.
Peters, U., McGlynn, K. A., Chatterjee, N., Gunter, E. W., García‐Closas, M., Rothman, N., & Sinha, R. R. (2001) · PubMed · Cited by 176 · see citing works
Persistent oxidative stress in human colorectal carcinoma, but not in adenoma
Kondo, S., Toyokuni, S., Iwasa, Y., Tanaka, T. U., Onodera, H., Hiai, H., & Imamura, M. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00087-8 · Cited by 160 · see citing works
Venturi, M. (1997) · Carcinogenesis · doi:10.1093/carcin/18.12.2353 · Cited by 160 · see citing works
Calcium, vitamin D, and colon cancer.
Lipkin, M., Newmark, H., Boone, C. W., & Kelloff, G. J. (1991) · PubMed · Cited by 155 · see citing works
Kesse‐Guyot, E., Boutron‐Ruault, M., Norat, T., Ríboli, E., Clavel‐Chapelon, F., & E3N Group (2005) · International Journal of Cancer · doi:10.1002/ijc.21148 · Cited by 148 · see citing works
Vitamin D and Prevention of Colorectal Adenoma: A Meta-analysis
Wei, M. Y., Garland, C. F., Gorham, E. D., Mohr, S. B., & Giovannucci, E. L. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0402 · Cited by 146 · see citing works
Hypothesis: Oxidative Stress Score as a Combined Measure of Pro-oxidant and Antioxidant Exposures
Goodman, M. G., Bostick, R. M., Dash, C., Flanders, W. D., & Mandel, J. S. (2007) · Annals of Epidemiology · doi:10.1016/j.annepidem.2007.01.034 · Cited by 143 · see citing works
Self-citationFedirko, V., Bostick, R. M., Flanders, W. D., Long, Q., Shaukat, A., Rutherford, R. E., Daniel, C. R., Cohen, V., & Dash, C. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0157 · Cited by 143 · see citing works
Self-citationSies, H., & Jones, D. P. (2007) · Elsevier eBooks · doi:10.1016/b978-012373947-6.00285-3 · Cited by 142 · see citing works
Vitamin D and genomic stability
Chatterjee, M. (2001) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(01)00080-x · Cited by 134 · see citing works
Bostick, R. M., Fosdick, L., Grambsch, P. M., Grandits, G. A., Louis, T. A., Potter, J. D., Wood, J. R., & Lillemoe, T. J. (1995) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/87.17.1307 · Cited by 133 · see citing works
Self-citationDietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Weingarten, M. A., Trestioreanu, A. Z., & Yaphe, J. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003548.pub4 · Cited by 125 · see citing works
Zheng, W., Anderson, K. E., Kushi, L. H., Sellers, T. A., Greenstein, J., Hong, C. P., Cerhan, J. R., Bostick, R. M., & Folsom, A. R. (1998) · PubMed · Cited by 124 · see citing works
Self-citationFedirko, V., Bostick, R. M., Flanders, W. D., Long, Q., Sidelnikov, E., Shaukat, A., Daniel, C. R., Rutherford, R. E., & Woodard, J. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0239 · Cited by 120 · see citing works
Self-citationVitamin D signaling is modulated on multiple levels in health and disease
Ebert, R., Schütze, N., Adamski, J., & Jakob, F. J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.039 · Cited by 118 · see citing works
Vitamin D and Colon Carcinogenesis
Harris, D. M., & Go, V. L. W. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3463s · Cited by 117 · see citing works
Vitamin D receptor activity and prevention of colonic hyperproliferation and oxidative stress
Kállay, E., Bareis, P., Bajna, E., Kriwanek, S., Bonner, E., Toyokuni, S., & Cross, H. S. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00030-3 · Cited by 109 · see citing works
Sardar, S., Chakraborty, A., & Chatterjee, M. (1996) · PubMed · Cited by 104 · see citing works
Sitrin, M. D., Halline, A. G., Abrahams, C., & Brasitus, T. A. (1991) · PubMed · Cited by 102 · see citing works
Calcium and Vitamin D Intakes in Relation to Risk of Distal Colorectal Adenoma in Women
Oh, K., Willett, W. C., Wu, K., Fuchs, C. S., & Giovannucci, E. L. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm026 · Cited by 100 · see citing works
Hollis, B. W. (1997) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(97)82106-4 · Cited by 95 · see citing works
Goodman, M. G., Bostick, R. M., Dash, C., Terry, P., Flanders, W. D., & Mandel, J. S. (2008) · Cancer Causes & Control · doi:10.1007/s10552-008-9169-y · Cited by 88 · see citing works
Self-citationBeaty, M. M., Lee, E. Y., & Glauert, H. P. (1993) · Journal of Nutrition · doi:10.1093/jn/123.1.144 · Cited by 72 · see citing works
1,25-Dihydroxyvitamin D3 regulates genes responsible for detoxification in intestine
Kutuzova, G. D., & DeLuca, H. F. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.10.005 · Cited by 67 · see citing works
Oxidative Damage to Nucleic Acids
Evans, M. D., & Cooke, M. S. (2007) · Springer eBooks · doi:10.1007/978-0-387-72974-9 · Cited by 65 · see citing works
Analysis of Oxidative DNA Damage in Patients with Colorectal Cancer
Ribeiro, M. L., Priolli, D. G., Miranda, D. D. C., Arçari, D. P., Pedrazzoli, J., & Martinez, C. A. R. (2008) · Clinical Colorectal Cancer · doi:10.3816/ccc.2008.n.034 · Cited by 59 · see citing works
Chemoprevention of Colorectal Neoplasia by Estrogen: Potential Role of Vitamin D Activity
Protiva, P., Cross, H. S., Hopkins, M. E., Kállay, E., Bises, G., Dreyhaupt, E., Augenlicht, L. H., Lipkin, M., LESSER, M. L., Livote, E. E., et al. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0103 · Cited by 54 · see citing works
Calcium intake and colorectal adenoma in a US colorectal cancer early detection program
Peters, U., Chatterjee, N., McGlynn, K. A., Schoen, R. E., Church, T. R., Bresalier, R. S., Gaudet, M. M., Flood, A. P., Schatzkin, A. G., & Hayes, R. B. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1358 · Cited by 53 · see citing works
Bostick, R. M., Fosdick, L., Lillemoe, T. J., Overn, P., Wood, J. R., Grambsch, P. M., Elmer, P. J., & Potter, J. D. (1997) · PubMed · Cited by 45 · see citing works
Self-citationPotter, J. D., & Lindor, N. M. (2009) · Springer eBooks · doi:10.1007/978-0-387-09568-4 · Cited by 29 · see citing works
Bostick, R. M., Goodman, M. G., & Sidelnikov, E. (2009) · Springer eBooks · doi:10.1007/978-0-387-09568-4_19 · Cited by 17 · see citing works
Self-citationAltered VDR-mediated transcriptional activity in prostate cancer stroma
Hidalgo, A. A., Paredes, R., Garcia-Gallegos, V. M., Flynn, G., Johnson, C. S., Trump, D. L., & Oñate, S. A. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.12.072 · Cited by 13 · see citing works
Mechanisms of Action of Vitamin D: Recent Findings and New Questions
Lipkin, M., & Lamprecht, S. A. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.135 · Cited by 4 · see citing works
Flagged first, then by citations
3 of the 59 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Nutrients, foods, and colorectal cancer prevention
Song, M., Garrett, W. S., & Chan, A. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.035 · Cited by 700 · see citing works
Vitamin D supplementation for prevention of mortality in adults
Bjelakovic, G., Gluud, L. L., Nikolova, D., Whitfield, K., Wetterslev, J., Simonetti, R. G., Bjelakovic, M., & Gluud, C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007470.pub3 · Cited by 695 · see citing works
Exploring vitamin D metabolism and function in cancer
Jeon, S., & Shin, E. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0038-9 · Cited by 554 · see citing works
Vitamin D and cancer: a review of molecular mechanisms
Fleet, J. C., DeSmet, M. L., Johnson, R., & Li, Y. (2011) · Biochemical Journal · doi:10.1042/bj20110744 · Cited by 411 · see citing works
Micronutrient deficiencies in inflammatory bowel disease: From A to zinc
Hwang, C., Ross, V., & Mahadevan, U. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22906 · Cited by 234 · see citing works
Vitamin D Activates the Nrf2-Keap1 Antioxidant Pathway and Ameliorates Nephropathy in Diabetic Rats
Nakai, K., Fujii, H., Kono, K., Goto, S., Kitazawa, R., Kitazawa, S., Hirata, M., Shinohara, M., Fukagawa, M., & Nishi, S. (2013) · American Journal of Hypertension · doi:10.1093/ajh/hpt160 · Cited by 217 · see citing works
Vitamin D supplementation for prevention of cancer in adults
Bjelaković, G., Gluud, L. L., Nikolova, D., Whitfield, K., Krstic, G., Wetterslev, J., & Gluud, C. N. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007469.pub2 · Cited by 211 · see citing works
Asemi, Z., Hashemi, T., Karamali, M., Samimi, M., & Esmaillzadeh, A. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.072785 · Cited by 201 · see citing works
RetractedExtraskeletal actions of vitamin D
Bikle, D. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13219 · Cited by 182 · see citing works
Vitamin D and mucosal immune function
Sun, J. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32833d4b9f · Cited by 164 · see citing works
Vitamin D supplementation for prevention of mortality in adults
Bjelaković, G., Gluud, L. L., Nikolova, D., Whitfield, K., Wetterslev, J., Simonetti, R. G., Bjelaković, M., & Gluud, C. N. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007470.pub2 · Cited by 157 · see citing works
Plasma Vitamin D Concentration Influences Survival Outcome After a Diagnosis of Colorectal Cancer
Zgaga, L., Τheodoratou, E., Farrington, S. M., Din, F. V. N., Ooi, L. Y., Głodzik, D., Johnston, S. S., Tenesa, A., Campbell, H., & Dunlop, M. G. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.5947 · Cited by 148 · see citing works
Asemi, Z., Karamali, M., & Esmaillzadeh, A. (2014) · Diabetologia · doi:10.1007/s00125-014-3293-x · Cited by 146 · see citing works
Hopkins, M. H., Owen, J. R., Ahearn, T. U., Fedirko, V., Flanders, W. D., Jones, D. P., & Bostick, R. M. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0105 · Cited by 138 · see citing works
Self-citationAsemi, Z., Samimi, M., Tabassi, Z., Shakeri, H., Sabihi, S.-S., & Esmaillzadeh, A. (2014) · Nutrition · doi:10.1016/j.nut.2014.03.008 · Cited by 136 · see citing works
Asemi, Z., Samimi, M., Tabassi, Z., Shakeri, H., & Esmaillzadeh, A. (2013) · Journal of Nutrition · doi:10.3945/jn.113.177550 · Cited by 131 · see citing works
RetractedPereira, F., Larriba, M. J., & Múñoz, A. (2012) · Endocrine Related Cancer · doi:10.1530/erc-11-0388 · Cited by 131 · see citing works
Vitamin D and pregnancy: An old problem revisited
Barrett, H. L., & McElduff, A. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.05.010 · Cited by 127 · see citing works
What is the role of vitamin D in autism?
Cannell, J. J., & Grant, W. B. (2013) · Dermato-Endocrinology · doi:10.4161/derm.24356 · Cited by 122 · see citing works
Vitamin D in cancer chemoprevention
Giammanco, M., Majo, D. D., Guardia, M. L., Aiello, S., Crescimanno, M., Flandina, C., Tumminello, F. M., & Leto, G. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2014.988274 · Cited by 120 · see citing works
Vitamin D and Autism Spectrum Disorder: A Literature Review
Mazahery, H., Camargo, C., Conlon, C., Beck, K., Kruger, M., & Von Hurst, P. (2016) · Nutrients · doi:10.3390/nu8040236 · Cited by 110 · see citing works
Antineoplastic effects of 1,25(OH)2D3 and its analogs in breast, prostate and colorectal cancer
Leyssens, C., Verlinden, L., & Verstuyf, A. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0381 · Cited by 109 · see citing works
Teixeira, T. M., da Costa, D. C., Resende, A. C., Soulage, C. O., Bezerra, F. F., & Daleprane, J. B. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.239475 · Cited by 106 · see citing works
Citronberg, J. S., Bostick, R. M., Ahearn, T. U., Turgeon, D. K., Ruffin, M. T., Djurić, Z., Sen, A., Brenner, D. E., & Zick, S. M. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0327 · Cited by 106 · see citing works
Self-citationThe Vitamin D Receptor as Tumor Suppressor in Skin
Bikle, D. D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-46227-7_14 · Cited by 96 · see citing works
lan, N., Luo, G., Yang, X., Cheng, Y., Zhang, Y., Wang, X., Wang, X., Xie, T., Li, G., Liu, Z., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111599 · Cited by 94 · see citing works
Does vitamin D protect against DNA damage?
Nair-Shalliker, V., Armstrong, B. K., & Fenech, M. (2012) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2012.02.005 · Cited by 92 · see citing works
Azadi‐Yazdi, M., Karimi‐Zarchi, M., Salehi‐Abargouei, A., Fallahzadeh, H., & Nadjarzadeh, A. (2017) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12433 · Cited by 88 · see citing works
Wenclewska, S., Szymczak-Pajor, I., Drzewoski, J., Bunk, M., & Śliwińska, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122891 · Cited by 90 · see citing works
Papier, K., Bradbury, K. E., Balkwill, A., Barnes, I. M., Smith-Byrne, K., Gunter, M. J., Berndt, S., Marchand, L. L., Wu, A. H., Peters, U., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55219-5 · Cited by 84 · see citing works
Brunner, R. L., Wactawski‐Wende, J., Caan, B. J., Cochrane, B. B., Chlebowski, R. T., Gass, M. L. S., Jacobs, E. T., LaCroix, A. Z., Lane, D. S., Larson, J. C., et al. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2011.594208 · Cited by 78 · see citing works
Vitamin D Supplementation: What's Known, What to Do, and What's Needed
Haines, S. T., & Park, S. K. (2012) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1037 · Cited by 78 · see citing works
Jain, S. K., Parsanathan, R., Levine, S. N., Bocchini, J. A., Holick, M. F., & Vanchiere, J. A. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.002 · Cited by 74 · see citing works
Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles
Bowe, W. P., & Logan, A. C. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-141 · Cited by 69 · see citing works
Karamali, M., Beihaghi, E., Mohammadi, A. A., & Asemi, Z. (2015) · Hormone and Metabolic Research · doi:10.1055/s-0035-1548835 · Cited by 68 · see citing works
Nutraceuticals for older people: Facts, fictions and gaps in knowledge
González‐Sarrías, A., Larrosa, M., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.05.006 · Cited by 66 · see citing works
Ahearn, T. U., McCullough, M. L., Flanders, W. D., Long, Q., Sidelnikov, E., Fedirko, V., Daniel, C. R., Rutherford, R. E., Shaukat, A., & Bostick, R. M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1560 · Cited by 61 · see citing works
Self-citationAttenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3
Halicka, H. D., Zhao, H. L., Li, J., Traganos, F., Studzinski, G. P., & Darżynkiewicz, Z. (2012) · Aging · doi:10.18632/aging.100450 · Cited by 61 · see citing works
Vitamin D deficiency and Alzheimer disease: Common links
Keeney, J. T. R., & Butterfield, D. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.06.020 · Cited by 59 · see citing works
Oxidative balance and colon and rectal cancer: Interaction of lifestyle factors and genes
Slattery, M. L., Lundgreen, A., Welbourn, B., Wolff, R. K., & Corcoran, C. D. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.04.002 · Cited by 56 · see citing works
Ahearn, T. U., Shaukat, A., Flanders, W. D., Rutherford, R. E., & Bostick, R. M. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0292 · Cited by 56 · see citing works
Self-citationBostick, R. M. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.01.010 · Cited by 54 · see citing works
Self-citationShen, M., Luo, Y.-S., Niu, Y.-M., Chen, L., Yuan, X.-Q., Goltzman, D., Chen, N., & Miao, D. (2013) · Bone · doi:10.1016/j.bone.2013.04.015 · Cited by 59 · see citing works
Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes
Piotrowska, A., Wierzbicka, J., Ślebioda, T., Woźniak, M., Tuckey, R. C., Slominski, A. T., & Żmijewski, M. A. (2016) · Steroids · doi:10.1016/j.steroids.2016.04.002 · Cited by 48 · see citing works
Quigley, M., Rieger, S., Capobianco, E., Wang, Z., Zhao, H., Hewison, M., & Lisse, T. S. (2021) · JBMR Plus · doi:10.1002/jbm4.10572 · Cited by 48 · see citing works
Vitamin D and cancer: the promise not yet fulfilled
Bikle, D. D. (2014) · Endocrine · doi:10.1007/s12020-013-0146-1 · Cited by 48 · see citing works
El-Ansary, A. K., Cannell, J. J., Bjørklund, G., Bhat, R. S., Al-Dbass, A. M., Alfawaz, H., Chirumbolo, S., & AL-Ayadhi, L. Y. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0199-1 · Cited by 48 · see citing works
New vitamin D analogs as potential therapeutics in melanoma
Szyszka, P., Zmijewski, M. A., & Slominski, A. T. (2012) · Expert Review of Anticancer Therapy · doi:10.1586/era.12.40 · Cited by 45 · see citing works
Racial disparity in death from colorectal cancer
Fiscella, K. A., Winters, P., Tancredi, D. J., Hendren, S. K., & Franks, P. J. (2010) · Cancer · doi:10.1002/cncr.25647 · Cited by 45 · see citing works
Dik, V. K., Murphy, N., Siersema, P. D., Fedirko, V., Jenab, M., Kong, S. Y., Hansen, C. P., Overvad, K., Tjønneland, A. M., Olsen, A., et al. (2014) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-0172 · Cited by 45 · see citing works
Self-citationAlfawaz, H. A., Bhat, R. S., Al-Ayadhi, L., & El-Ansary, A. K. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-416 · Cited by 44 · see citing works
Amaral, A. F. S., Méndez‐Pertuz, M., Múñoz, A., Silverman, D. T., Allory, Y., Kogevinas, M., Lloreta, J., Rothman, N., Carrato, A., del Fresno, M. R., et al. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs444 · Cited by 36 · see citing works
Toossi, P. (2015) · Clinical cases in mineral and bone metabolism · doi:10.11138/ccmbm/2015.12.3.238 · Cited by 36 · see citing works
Piotrowska, A., Wierzbicka, J., Rybarczyk, A., Tuckey, R. C., Slominski, A. T., & Zmijewski, M. A. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4725 · Cited by 36 · see citing works
Rinninella, E., Mele, M. C., Raoul, P. C., Cintoni, M., & Gasbarrini, A. (2021) · BioFactors · doi:10.1002/biof.1786 · Cited by 34 · see citing works
Vitamin D and cancer: Deciphering the truth
D, S. M. M. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.07.001 · Cited by 33 · see citing works
Diet, Microbiota, and Colorectal Cancer
Grazioso, T. P., Brandt, M., & Djouder, N. (2019) · iScience · doi:10.1016/j.isci.2019.10.011 · Cited by 33 · see citing works
Heulens, N., Korf, H., & Janssens, W. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.223032 · Cited by 33 · see citing works
Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas
Brożyna, A. A., Jóźwicki, W., Jochymski, C., & Slominski, A. T. (2014) · Oncology Reports · doi:10.3892/or.2014.3666 · Cited by 33 · see citing works
Esmaillzadeh, A., Asemi, Z., Samimi, M., Siavashani, M. A., Mazloomi, M., Tabassi, Z., Karamali, M., & Jamilian, M. (2016) · International Journal of Preventive Medicine · doi:10.4103/2008-7802.177895 · Cited by 32 · see citing works
Immunochemical detection of oxidatively damaged DNA
Rössner, P., & Šrám, R. J. (2011) · Free Radical Research · doi:10.3109/10715762.2011.632415 · Cited by 29 · see citing works
Vitamin D changes expression of DNA repair genes in the patients with multiple sclerosis
Amirinejad, R., Shirvani-Farsani, Z., Gargari, B. N., Sahraian, M. A., Soltani, B. M., & Behmanesh, M. (2021) · Gene · doi:10.1016/j.gene.2021.145488 · Cited by 29 · see citing works
Sehdev, A., & O’Neil, B. H. (2015) · Current Treatment Options in Oncology · doi:10.1007/s11864-015-0359-z · Cited by 29 · see citing works
Mohammed, M. A., Aboulhoda, B., & Mahmoud, R. (2018) · Human & Experimental Toxicology · doi:10.1177/0960327118812166 · Cited by 28 · see citing works
Mohseni, H., Amani, R., Hosseini, S. A., Ekrami, A., Ahmadzadeh, A., & Latifi, S. M. (2019) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2019.20.7.2065 · Cited by 28 · see citing works
Usman, M., Woloshynowych, M., Britto, J. C., Bilkevic, I., Glassar, B., Chapman, S., Ford‐Adams, M., Desai, A. P., Bain, M. D., Tewfik, I., et al. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00879-2 · Cited by 27 · see citing works
Nair‐Shalliker, V., Fenech, M. F., Forder, P., Clements, M., & Armstrong, B. K. (2012) · Mutagenesis · doi:10.1093/mutage/ges026 · Cited by 26 · see citing works
Um, C. Y., Prizment, A. E., Hong, C.-P., Lazovich, D., & Bostick, R. M. (2019) · British Journal Of Nutrition · doi:10.1017/s000711451900045x · Cited by 26 · see citing works
Self-citationIs Vitamin D Deficiency Related to Increased Cancer Risk in Patients with Type 2 Diabetes Mellitus?
Gabryanczyk, A., Klimczak, S., Szymczak-Pajor, I., & Śliwińska, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126444 · Cited by 25 · see citing works
Farag, H. A. M., Hosseinzadeh‐Attar, M. J., Muhammad, B. A., Esmaillzadeh, A., & Bilbeisi, A. H. E. (2018) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-018-0384-8 · Cited by 25 · see citing works
Borská, L., Andrýs, C., Krejsek, J., Palička, V., Voříšek, V., Hamáková, K., Kremláček, J., Borský, P., & Fiala, Z. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.12.010 · Cited by 23 · see citing works
Unlocking the potential of milk whey protein components in colorectal cancer prevention and therapy
Xiao, J., Ma, J., Khan, M. Z., Alugongo, G. M., Chen, T., Liu, S., Li, S., & Cao, Z. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2258970 · Cited by 23 · see citing works
Alamri, A., Burzangi, A., Coats, P., & Watson, D. (2018) · Metabolites · doi:10.3390/metabo8040087 · Cited by 21 · see citing works
Yang, B., Bostick, R. M., Tran, H. Q., Gewirtz, A. T., Campbell, P. T., & Fedirko, V. (2015) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-0488 · Cited by 22 · see citing works
Self-citationZhang, Y., Li, C.-N., Jiang, W., Wu, P., Liu, Y., Kuang, S., Tang, L. Y., Li, S., Jin, X., Ren, H., et al. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.739144 · Cited by 21 · see citing works
Ishikawa, H., Goto, M., Matsuura∥, N., Murakami, Y., Goto, C., Sakai, T., & Kanazawa, K. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720434 · Cited by 20 · see citing works
Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth
Ruggiero, C., Tafaro, L., Cianferotti, L., Tramontana, F., Macchione, I. G., Caffarelli, C., Virdis, A., Ferracci, M., Rinonapoli, G., Mecocci, P., et al. (2024) · Nutrients · doi:10.3390/nu16060906 · Cited by 19 · see citing works
Glycine ameliorates liver injury and vitamin D deficiency induced by bile duct ligation
Chen, C., Wang, B.-T., Wu, Z.-C., Yu, W.-T., Lin, P., Tsai, W.-L., & Shiesh, S. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.10.016 · Cited by 19 · see citing works
Vaughan-Shaw, P. G., Blackmur, J. P., Grimes, G. R., Ooi, L. Y., Ochocka-Fox, A. M., Dunbar, K. J., von Kriegsheim, A., Rajasekaran, V., Timofeeva, M. N., Walker, M., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202101430rr · Cited by 18 · see citing works
Um, C. Y., Prizment, A. E., Hong, C.-P., Lazovich, D., & Bostick, R. M. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1539188 · Cited by 18 · see citing works
Self-citationDavis, C. D., & Milner, J. A. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.10.89 · Cited by 17 · see citing works
Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells
Yang, W., Liu, L., Keum, N., Qian, Z. R., Nowak, J. A., Hamada, T., Song, M., Cao, Y., Nosho, K., Smith‐Warner, S. A., et al. (2019) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-18-0279 · Cited by 17 · see citing works
Impact of Diet on Colorectal Cancer Progression and Prevention: From Nutrients to Neoplasms
Kim, S. H., Park, D. H., & Lim, Y. J. (2023) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2023.079 · Cited by 16 · see citing works
Ahearn, T. U., Shaukat, A., Flanders, W. D., Seabrook, M. E., & Bostick, R. M. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0126 · Cited by 15 · see citing works
Self-citationTu, H., Flanders, W. D., Ahearn, T. U., Daniel, C. R., Gonzalez‐Feliciano, A. G., Long, Q., Rutherford, R. E., & Bostick, R. M. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.22096 · Cited by 15 · see citing works
Self-citationTo D or not to D: vitamin D in hematopoietic cell transplantation
Hong, S., Ferraro, C. S., Hamilton, B. K., & Majhail, N. S. (2020) · Bone Marrow Transplantation · doi:10.1038/s41409-020-0904-7 · Cited by 14 · see citing works
The role of vitamin D in head and neck cancer
Izreig, S., Hajek, M., Edwards, H., Mehra, S., Sasaki, C. T., Judson, B. L., & Rahmati, R. (2020) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.469 · Cited by 14 · see citing works
Wang, Z., Wang, W., Yang, A., Zhao, W., Yang, H. J., Wang, Z., Wang, W., Su, X., Wang, J., Song, J., et al. (2020) · Journal of Cancer · doi:10.7150/jca.39806 · Cited by 13 · see citing works
Asemi, Z., Samimi, M., Heidarzadeh, Z., Khorrammian, H., & Tabassi, Z. (2012) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2012.469.476 · Cited by 13 · see citing works
Snoeijs, P., Sylvander, P., & Häubner, N. (2011) · Wiley eBooks · doi:10.1002/9781444345988.ch5 · Cited by 12 · see citing works
O’Callaghan‐Gordo, C., Kogevinas, M., Fthenou, E., Pedersen, M., Espinosa, A., Chalkiadaki, G., Daraki, V. N., Dermitzaki, E., Decordier, I., Georgiou, V., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.06.016 · Cited by 11 · see citing works
Vitamin D and oxidation-induced DNA damage: is there a connection?
Wang, E. W., Collins, A. R., Pang, M. Y. C., Siu, P. M., Lai, C. K. Y., Woo, J., & Benzie, I. F. F. (2016) · Mutagenesis · doi:10.1093/mutage/gew033 · Cited by 11 · see citing works
van Leeuwen, J. P. T. M., van Driel, M., Feldman, D., & Múñoz, A. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10083-6 · Cited by 11 · see citing works
Maity, B., Bora, M., & Sur, D. (2018) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-018-0311-4 · Cited by 10 · see citing works
Zheng, X., Lipka, S., Li, T., Shahzad, G., Levine, E., Vlacancich, R., Takeshige, U., & Mustacchia, P. J. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.09.018 · Cited by 9 · see citing works
Marigoudar, J. B., Sarkar, D., Yuguda, Y. M., Abutayeh, R. F., Kaur, A. P., Pati, A., Mitra, D., Ghosh, A., Banerjee, D., Borah, S., et al. (2022) · Medical Oncology · doi:10.1007/s12032-022-01855-0 · Cited by 9 · see citing works
Diet quality and colorectal tumor risk in persons with Lynch syndrome
Eijkelboom, A. H., Brouwer, J. G. M., Vasen, H. F. A., Bisseling, T. M., Koornstra, J. J., Kampman, E., & van Duijnhoven, F. J. B. (2020) · Cancer Epidemiology · doi:10.1016/j.canep.2020.101809 · Cited by 9 · see citing works
Mao, Z., Prizment, A. E., Lazovich, D., Gibbs, D. C., & Bostick, R. M. (2020) · Nutrition and Cancer · doi:10.1080/01635581.2020.1821904 · Cited by 9 · see citing works
Self-citationTaghizadeh, M., Samimi, M., Tabassi, Z., Heidarzadeh, Z., & Asemi, Z. (2014) · Oman Medical Journal · doi:10.5001/omj.2014.30 · Cited by 9 · see citing works
Burhannudin, B., Mahmudah, N. A. R. A. A., Widyarini, S., & Purnomosari, D. (2018) · Europe PMC (PubMed Central) · doi:10.22034/apjcp.2018.19.3.839 · Cited by 9 · see citing works
- Authors
- Fedirko, V., Bostick, R. M., Long, Q., Flanders, W. D., McCullough, M. L., Sidelnikov, E., Daniel, C. R., Rutherford, R. E., & Shaukat, A.
- Affiliations
- American Cancer Society (US)
- Corresponding author
- Bostick, Roberd M.
- ORCID
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2010-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 280-291
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- PMC
- PMC2805163
- OpenAlex
- W2112110686
- Cited by
- 150
- References
- 59
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 2 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 13 · 2017: 2 · 2016: 9 · 2015: 13 · 2014: 15 · 2013: 15 · 2012: 17
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Georgia Cancer Coalition
- Emory University
- National Institutes of Health
- National Cancer Institute (R03CA136113, R01CA104637)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- vitamin D3, calcium supplementation, oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, colorectal mucosa, vitamin D receptor, colorectal adenoma, colorectal cancer chemoprevention, oxidative stress, DNA damage biomarkers
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Adenoma, Adult, Aged, Calcium Carbonate, Calcium, Dietary, Cholecalciferol, Deoxyguanosine, DNA Damage, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Intestinal Mucosa, Intestinal Neoplasms, Male, Middle Aged, Pilot Projects, Precancerous Conditions, Biomarkers, Tumor, Oxidative Stress, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
