The response to DNA damage during differentiation: Pathways and consequences
Abstract
Damage to genomic DNA triggers a prompt set of signaling events known as the DNA damage response (DDR) which coordinates DNA repair, cell cycle arrest and ultimately cell death or senescence. Although activation of adequate DNA damage signaling and repair systems depends on the type of lesion and the cell-cycle phase in which it occurs, emerging evidence indicates that DNA repair and DDR function differently in different cellular contexts. Depending on the time maintenance and function of a specific cell type the risk of accumulating DNA damage may vary. For instance, damage to stem cells if not repaired can lead to mutation amplification or propagation through the processes of self-renewal and differentiation, respectively, whereas damage to post-mitotic cells can affect mostly tissue homeostasis. Stem cells are therefore expected to address DNA damage differently from their somatic counterparts. In this review the information available on the common and distinct mechanisms of control of genome integrity utilized by different cell types along the self-renewal/differentiation program will be reviewed, with special emphasis on their roles in the prevention of aging and disease.
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DDR pathways that safeguard genomic integrity may show reduced activity in stem cells with age.
“These observations suggest that DDR pathways, evolved to safeguard genomic integrity and maximize survival of the organism13,44–46, may show reduced activity in stem cells with age.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [45]
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Stem cell aging: mechanisms, regulators and therapeutic opportunities
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- Authors
- Fortini, P., Ferretti, C., & Dogliotti, E.
- Affiliations
- Istituto Superiore di Sanità (IT)
- ORCID
- Fortini, Paola
- Venue
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 743-744
- Pages
- 160-168
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W2006305985
- Cited by
- 45
- References
- 108
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 4 · 2013: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- DNA damage response, DNA repair, cell differentiation, stem cells, self-renewal, genome stability, cell cycle arrest, cell death, senescence, mutation accumulation, tissue homeostasis, aging, postmitotic cells
- MeSH terms
- Animals, Cell Differentiation, DNA Damage, DNA Repair, Humans, Signal Transduction, Cell Death
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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