Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,626 · see citing works

Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology

Gygi, S. P., Corthals, G. L., Zhang, Y., Rochon, Y. P., & Aebersold, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160270797 · Cited by 1,311 · see citing works

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311 · see citing works

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,253 · see citing works

PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth

Rosen, E. D., & Spiegelman, B. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100034200 · Cited by 1,174 · see citing works

The key role of anaplerosis and cataplerosis for citric acid cycle function

Owen, O. E., Kalhan, S. C., & Hanson, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200006200 · Cited by 1,172 · cited 2× · see citing works

Cross-Regulation of C/EBPα and PPARγ Controls the Transcriptional Pathway of Adipogenesis and Insulin Sensitivity

Wu, Z., Rosen, E. D., Brun, R. P., Hauser, S., Adelmant, G., Troy, A. E., McKeon, C., Darlington, G., & Spiegelman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80306-8 · Cited by 1,015 · see citing works

A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption/ionization and electrospray ionization- mass spectrometry

Yan, J. X., Wait, R., Berkelman, T., Harry, R. A., Westbrook, J. A., Wheeler, C., & Dunn, M. J. (2000) · Electrophoresis · doi:10.1002/1522-2683(200011)21:17 · Cited by 705 · see citing works

The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance

Yamauchi, T., Kamon, J., Waki, H., Murakami, K., Motojima, K., Komeda, K., Ide, T., Kubota, N., Terauchi, Y., Tobe, K., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103241200 · Cited by 635 · see citing works

Partial leptin deficiency and human adiposity

Farooqi, I. S., Keogh, J. M., Kamath, S., Jones, S., Gibson, W. T., Trussell, R., Jebb, S. A., Lip, G. Y. H., & O'Rahilly, S. (2001) · Nature · doi:10.1038/35102112 · Cited by 407 · see citing works

Electron Tomography of Neuronal Mitochondria: Three-Dimensional Structure and Organization of Cristae and Membrane Contacts

Perkins, G. A., Renken, C. W., Martone, M. E., Young, S. J., Ellisman, M. H., & Frey, T. (1997) · Journal of Structural Biology · doi:10.1006/jsbi.1997.3885 · Cited by 396 · see citing works

PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells

Andersson, U., & Scarpulla, R. C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3738-3749.2001 · Cited by 374 · see citing works

Background-free, high sensitivity staining of proteins in one- and two-dimensional sodium dodecyl sulfate-polyacrylamide gels using a luminescent ruthenium complex

Berggren, K. N., Chernokalskaya, E., Steinberg, T. H., Kemper, C., Lopez, M. F., Diwu, Z., Haugland, R. P., & Patton, W. F. (2000) · Electrophoresis · doi:10.1002/1522-2683(20000701)21:12 · Cited by 356 · see citing works

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

Häcki, J., Egger, L., Monney, L., Conus, S., Rossé, T., Fellay, I., & Borner, C. (2000) · Oncogene · doi:10.1038/sj.onc.1203592 · Cited by 300 · see citing works

Mass spectrometry and proteomics

Gygi, S. P., & Aebersold, R. H. (2000) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(00)00121-6 · Cited by 291 · see citing works

Role of PPARγ in Regulating Adipocyte Differentiation and Insulin‐Responsive Glucose Uptake

HAMM, J. K., EL JACK, A. K., PILCH, P. F., & FARMER, S. R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07792.x · Cited by 123 · see citing works

Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat

Chalkley, S. M., Hettiarachchi, M., Chisholm, D. J., & Kraegen, E. W. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90287-6 · Cited by 109 · see citing works

Insulin Action on GLUT4 Traffic Visualized in Single 3T3-L1 Adipocytes by Using Ultra-fast Microscopy

Patki, V., Buxton, J. M., Chawla, A., Lifshitz, L. M., Fogarty, K. E., Carrington, W. A., Tuft, R. A., & Corvera, S. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.129 · Cited by 108 · see citing works

Potentiation of Glucose Uptake in 3T3-L1 Adipocytes by PPARγ Agonists Is Maintained in Cells Expressing a PPARγ Dominant-Negative Mutant: Evidence for Selectivity in the Downstream Responses to PPARγ Activation

Nugent, C., Prins, J. B., Whitehead, J. P., Savage, D. B., Wentworth, J. M., Chatterjee, K., & O’Rahilly, S. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.10.0715 · Cited by 93 · see citing works

Thiazolidinedione Treatment Prevents Free Fatty Acid–Induced Insulin Resistance in Male Wistar Rats

Hevener, A. L., Reichart, D. R., Janež, A., & Olefsky, J. M. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2316 · Cited by 78 · see citing works

Intracellular trafficking of phospholipids: import of phosphatidylserine into mitochondria.

Vance, J. E., & Shiao, Y. J. (1996) · PubMed · Cited by 69 · see citing works

A stress-regulated protein, GRP58, a member of thioredoxin superfamily, is a carnitine palmitoyltransferase isoenzyme

Murthy, M. S., & Pande, S. V. (1994) · Biochemical Journal · doi:10.1042/bj3040031 · Cited by 45 · see citing works

Comparison of adipose tissue changes following administration of rosiglitazone in the dog and rat

Toseland, C. D. N., Campbell, S., Francis, I., Bugelski, P. J., & Mehdi, N. (2001) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2001.00117.x · Cited by 43 · see citing works

Tissue-specific actions of antidiabetic thiazolidinediones on the reduced fatty acid oxidation in skeletal muscle and liver of zucker diabetic fatty rats

Ide, T., NAKAZAWA, T., Mochizuki, T., & Murakami, K. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80019-0 · Cited by 41 · see citing works

Carnitine medium/long chain acyltransferase of microsomes seems to be the previously cloned ?54 kDa protein of unknown function

Murthy, M. S. R., & Pande, S. V. (1993) · Molecular and Cellular Biochemistry · doi:10.1007/bf01076097 · Cited by 16 · see citing works

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263 · see citing works

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,241 · see citing works

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

Chen, Q., Shou, P., Zheng, C., Jiang, M., Cao, G., Yang, Q., Cao, J., Xie, N., Velletri, T., Zhang, X., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.168 · Cited by 1,245 · see citing works

Adaptive thermogenesis in adipocytes: Is beige the new brown?

Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes & Development · doi:10.1101/gad.211649.112 · Cited by 828 · see citing works

Proteomic Analysis of Proteins Associated with Lipid Droplets of Basal and Lipolytically Stimulated 3T3-L1 Adipocytes

Brasaemle, D., Dolios, G., Shapiro, L. S., & Wang, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409340200 · Cited by 804 · see citing works

Transcriptional integration of mitochondrial biogenesis

Scarpulla, R. C., Vega, R. B., & Kelly, D. P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.06.006 · Cited by 798 · see citing works

Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

Gleyzer, N., Vercauteren, K., & Scarpulla, R. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1354-1366.2005 · Cited by 711 · see citing works

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

Tormos, K. V., Ansó, E., Hamanaka, R. B., Eisenbart, J. D., Joseph, J., Kalyanaraman, B., & Chandel, N. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.007 · Cited by 662 · see citing works

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

Yoneda, T., Benedetti, C., Urano, F., Clark, S. G., Harding, H. P., & Ron, D. (2004) · Journal of Cell Science · doi:10.1242/jcs.01275 · Cited by 636 · see citing works

Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists

Nawrocki, A. R., Rajala, M. W., Tomás, E., Pajvani, U. B., Saha, A. K., Trumbauer, M. E., Pang, Z., Chen, A. S., Ruderman, N. B., Chen, H., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505311200 · Cited by 640 · see citing works

Transcriptional Control of Mitochondrial Biogenesis and Function

Hock, M. B., & Kralli, A. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163119 · Cited by 616 · see citing works

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works

Adipokines as novel biomarkers and regulators of the metabolic syndrome

Deng, Y., & Scherer, P. E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05875.x · Cited by 560 · see citing works

The role of mitochondria in the pathogenesis of type 2 diabetes

Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works

A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin Sensitivity

Combs, T. P., Pajvani, U. B., Berg, A. H., Lin, Y., Jelicks, L. A., Laplante, M., Nawrocki, A. R., Rajala, M. W., Parlow, A. F., Cheeseboro, L., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1068 · Cited by 545 · see citing works

Nuclear control of respiratory gene expression in mammalian cells

Scarpulla, R. C. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20743 · Cited by 489 · see citing works

Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo

Bogacka, I., Xie, H., Bray, G. A., & Smith, S. R. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1392 · Cited by 467 · see citing works

Inflamed Adipose Tissue

Gustafson, B., Hammarstedt, A., Andersson, C. X., & Smith, U. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147835 · Cited by 434 · see citing works

Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC‐1‐Related Coactivator

Scarpulla, R. C. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.006 · Cited by 389 · see citing works

Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents

Bjørndal, B., Burri, L., Staalesen, V., Skorve, J., & Berge, R. K. (2011) · Journal of Obesity · doi:10.1155/2011/490650 · Cited by 372 · see citing works

Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD

Kolenc, O. I., & Quinn, K. P. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7451 · Cited by 372 · see citing works

Mitochondrial dysfunction in white adipose tissue

Kusminski, C. M., & Scherer, P. E. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.06.004 · Cited by 368 · see citing works

Mitochondria are impaired in the adipocytes of type 2 diabetic mice.

Choo, H.-J., Kim, J.-H., Kwon, O.-B., Lee, C. S., Mun, J. Y., Han, S. S., Yoon, Y.-S., Yoon, G., Choi, K.-M., & Ko, Y.-G. (2006) · Diabetologia · doi:10.1007/s00125-006-0170-2 · Cited by 365 · see citing works

Adipose Acyl-CoA Synthetase-1 Directs Fatty Acids toward β-Oxidation and Is Required for Cold Thermogenesis

Ellis, J. M., Li, L. O., Wu, P.-C., Koves, T. R., Ilkayeva, O., Stevens, R. D., Watkins, S. M., Muoio, D. M., & Coleman, R. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.012 · Cited by 359 · see citing works

BOARD-INVITED REVIEW: The biology and regulation of preadipocytes and adipocytes in meat animals1,2

Hausman, G., Dodson, M. V., Ajuwon, K. M., Azain, M. J., Barnes, K. M., Guan, L. L., Jiang, Z., Poulos, S. P., Sainz, R. D., Smith, S. B., et al. (2008) · Journal of Animal Science · doi:10.2527/jas.2008-1427 · Cited by 343 · see citing works

Adipose Mitochondrial Biogenesis Is Suppressed in <i>db/db</i> and High-Fat Diet–Fed Mice and Improved by Rosiglitazone

Rong, J. X., Qiu, Y., Hansen, M. K., Zhu, L., Zhang, V., Xie, M., Okamoto, Y., Mattie, M. D., Higashiyama, H., Asano, S., et al. (2007) · Diabetes · doi:10.2337/db06-1135 · Cited by 335 · see citing works

Effects of Oxidative Stress on Mesenchymal Stem Cell Biology

Denu, R. A., & Hematti, P. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2989076 · Cited by 331 · see citing works

The secretory function of adipocytes in the physiology of white adipose tissue

Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318 · see citing works

Secretion of the Adipocyte-Specific Secretory Protein Adiponectin Critically Depends on Thiol-Mediated Protein Retention

Wang, Z. V., Schraw, T., Kim, J., Khan, T., Rajala, M. W., Follenzi, A., & Scherer, P. E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00931-06 · Cited by 305 · see citing works

Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity

Li, J., Romestaing, C., Han, X., Li, Y., Hao, X., Wu, Y., Sun, C., Liu, X., Jefferson, L. S., Xiong, J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.07.003 · Cited by 294 · see citing works

Oxidative stress and metabolic pathologies: from an adipocentric point of view

Le Lay, S., Simard, G., Martinez, M. C., & Andriantsitohaina, R. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/908539 · Cited by 291 · see citing works

Adiponectin Secretion Is Regulated by SIRT1 and the Endoplasmic Reticulum Oxidoreductase Ero1-Lα

Qiang, L., Wang, H., & Farmer, S. R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02279-06 · Cited by 290 · see citing works

Cellular and molecular effects ofn−3 polyunsaturated fatty acids on adipose tissue biology and metabolism

Flachs, P., Rossmeisl, M., Bryhn, M., & Kopecký, J. (2008) · Clinical Science · doi:10.1042/cs20070456 · Cited by 284 · see citing works

Pharmacological and nutritional agents promoting browning of white adipose tissue

Bonet, M. L., Oliver, P., & Palou, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.002 · Cited by 276 · see citing works

Quantitative metabolic imaging using endogenous fluorescence to detect stem cell differentiation

Quinn, K. P., Sridharan, G. V., Hayden, R. S., Kaplan, D. L., Lee, K., & Georgakoudi, I. (2013) · Scientific Reports · doi:10.1038/srep03432 · Cited by 278 · see citing works

The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases

Lee, J. H., Park, A., Oh, K., Lee, S. C., Kim, W. K., & Bae, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194924 · Cited by 270 · see citing works

Essential role of mitochondrial function in adiponectin synthesis in adipocytes

Koh, E. H., Park, J.-Y., Park, H.-S., Jeon, M. J., Ryu, J. W., Kim, M., Kim, S. Y., Kim, M.-S., Kim, S.-W., Park, I. S., et al. (2007) · Diabetes · doi:10.2337/db07-0510 · Cited by 275 · see citing works

Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations

Pauw, A. D., Tejerina, S., Raes, M. J., Keijer, J., & Arnould, T. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081155 · Cited by 270 · see citing works

A thrifty variant in CREBRF strongly influences body mass index in Samoans

Minster, R. L., Hawley, N. L., Su, C.-T., Sun, G., Kershaw, E. E., Cheng, H., Buhule, O. D., Lin, J., Reupena, M. S., Viali, S., et al. (2016) · Nature Genetics · doi:10.1038/ng.3620 · Cited by 264 · see citing works

Mitochondrial Respiration Regulates Adipogenic Differentiation of Human Mesenchymal Stem Cells

Zhang, Y., Marsboom, G., Tóth, P. T., & Rehman, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077077 · Cited by 244 · see citing works

White adipose tissue mitochondrial metabolism in health and in obesity

Heinonen, S., Jokinen, R., Rissanen, A., & Pietiläinen, K. H. (2019) · Obesity Reviews · doi:10.1111/obr.12958 · Cited by 243 · see citing works

Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes

Powelka, A. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26040 · Cited by 236 · see citing works

Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics

Forni, M. F., Peloggia, J., Trudeau, K. M., Shirihai, O. S., & Kowaltowski, A. J. (2015) · Stem Cells · doi:10.1002/stem.2248 · Cited by 233 · see citing works

Mitochondria in White, Brown, and Beige Adipocytes

Čedíková, M., Kripnerová, M., Dvořáková, J., Pitule, P., Grundmanova, M., Babuška, V., Müllerová, D., & Kuncová, J. (2016) · Stem Cells International · doi:10.1155/2016/6067349 · Cited by 237 · see citing works

Adipocyte Mitochondrial Function Is Reduced in Human Obesity Independent of Fat Cell Size

Yin, X. L., Lanza, I. R., Swain, J. M., Sarr, M. G., Nair, K. S., & Jensen, M. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3042 · Cited by 226 · see citing works

Mitochondrial Reactive Oxygen Species Control the Transcription Factor CHOP-10/GADD153 and Adipocyte Differentiation

Carrière, A., Carmona, M.-C., Fernandez, Y., Rigoulet, M., Wenger, R. H., Pénicaud, L., & Casteilla, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407258200 · Cited by 220 · see citing works

Secretome of Primary Cultures of Human Adipose-derived Stem Cells

Zvonic, S., LeFevre, M. L., Kilroy, G. E., Floyd, Z. E., DeLany, J. P., Kheterpal, I., Gravois, A., Dow, R., White, A., Wu, X., et al. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600217-mcp200 · Cited by 208 · see citing works

C/EBPα and the Corepressors CtBP1 and CtBP2 Regulate Repression of Select Visceral White Adipose Genes during Induction of the Brown Phenotype in White Adipocytes by Peroxisome Proliferator-Activated Receptor γ Agonists

Vernochet, C., Peres, S. B., Davis, K. E., McDonald, M. E., Qiang, L., Wang, H., Scherer, P. E., & Farmer, S. R. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01899-08 · Cited by 199 · see citing works

The Impact of Oxidative Stress on Adipose Tissue Energy Balance

Masschelin, P. M., Cox, A. R., Chernis, N., & Hartig, S. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01638 · Cited by 200 · see citing works

DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination

Guo, W., Jiang, L., Bhasin, S., Khan, S. M., & Swerdlow, R. H. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.03.003 · Cited by 183 · see citing works

Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1α Gene Transcription: An Autoregulatory Loop Controls PGC-1α Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor-γ Coactivation

Hondares, E., Mora, O., Yubero, P., de la Concepción, M. L. R., Iglesias, R., Giralt, M., & Villarroya, F. (2006) · Endocrinology · doi:10.1210/en.2006-0070 · Cited by 183 · see citing works

Emerging role of mitophagy in human diseases and physiology

Um, J., & Yun, J. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.6.056 · Cited by 181 · see citing works

Mapping metabolic changes by noninvasive, multiparametric, high-resolution imaging using endogenous contrast

Liu, Z., Pouli, D., Alonzo, C., Varone, A., Karaliota, S., Quinn, K. P., Münger, K., Karalis, K. P., & Georgakoudi, I. (2018) · Science Advances · doi:10.1126/sciadv.aap9302 · Cited by 175 · see citing works

RIP140-Targeted Repression of Gene Expression in Adipocytes

Christian, M., Kiskinis, E., Debevec, D., Leonardsson, G., White, R., & Parker, M. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9383-9391.2005 · Cited by 181 · see citing works

Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes

Hao, J., Shen, W., Yu, G., Jia, H., Li, X., Feng, Z., Wang, Y., Weber, P., Wertz, K., Sharman, E. H., et al. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.03.012 · Cited by 179 · see citing works

Regulatory circuits controlling white versus brown adipocyte differentiation

Hansen, J. B., & Kristiansen, K. (2006) · Biochemical Journal · doi:10.1042/bj20060402 · Cited by 178 · see citing works

MYC and Mitochondrial BiogenesisPreprint

Morrish, F. M., & Hockenbery, D. M. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014225 · Cited by 175 · see citing works

Enhanced angiogenesis in obesity and in response to PPARγ activators through adipocyte VEGF and ANGPTL4 production

Gealekman, O., Burkart, A., Chouinard, M., Nicoloro, S. M. C., Straubhaar, J., & Corvera, S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90345.2008 · Cited by 174 · see citing works

Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet

Ahn, J., Cho, I., Kim, S., Kwon, D., & Ha, T. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.08.012 · Cited by 173 · see citing works

BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells

Elsen, M., Raschke, S., Tennagels, N., Schwahn, U., Jeleník, T., Roden, M., Romacho, T., & Eckel, J. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00290.2013 · Cited by 168 · see citing works

Reactive species and early manifestation of insulin resistance in type 2 diabetes

Fridlyand, L. E., & Philipson, L. H. (2005) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00496.x · Cited by 166 · see citing works

Molecular determinants of brown adipocyte formation and function: Figure 1.

Farmer, S. R. (2008) · Genes &amp; Development · doi:10.1101/gad.1681308 · Cited by 165 · see citing works

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

Papkovskaia, T. D., Chau, K., Iñesta-Vaquera, F., Papkovsky, D. B., Healy, D. G., Nishio, K., Staddon, J. M., Duchen, M. R., Hardy, J., Schapira, A. H. V., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds244 · Cited by 164 · see citing works

Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition

Mori, H., Prestwich, T. C., Reid, M. A., Longo, K. A., Gerin, I., Cawthorn, W. P., Susulic, V. S., Krishnan, V., Greenfield, A., & MacDougald, O. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63604 · Cited by 162 · see citing works

Lipid raft proteome reveals ATP synthase complex in the cell surface

Bae, T., Kim, M., Kim, J., Kim, B., Choo, H. J., Lee, J., Kim, K., Lee, C. S., Kim, J., Chang, S. Y., et al. (2004) · PROTEOMICS · doi:10.1002/pmic.200400952 · Cited by 161 · see citing works

Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1α and PPARβ/δ gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus

Mensink, M., Hesselink, M. K. C., Russell, A. P., Schaart, G., Sels, J.-P., & Schrauwen, P. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803567 · Cited by 160 · see citing works

Peroxiredoxin 3 Is a Key Molecule Regulating Adipocyte Oxidative Stress, Mitochondrial Biogenesis, and Adipokine Expression

Huh, J. Y., Kim, Y., Jeong, J., Park, J., Kim, I., Huh, K. H., Kim, Y. S., Woo, H. A., Rhee, S. G., Lee, K., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3766 · Cited by 157 · see citing works

Insulin Resistance and Mitochondrial Dysfunction

González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 154 · see citing works

MicroRNA-27 (miR-27) Targets Prohibitin and Impairs Adipocyte Differentiation and Mitochondrial Function in Human Adipose-derived Stem Cells

Kang, T., Lu, W., Xu, W., Anderson, L. M., Bacanamwo, M., Thompson, W. E., Chen, Y. E., & Liu, D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.514372 · Cited by 154 · see citing works

Proteomic Analysis of Primary Cultures of Human Adipose-derived Stem Cells

DeLany, J. P., Floyd, Z. E., Zvonic, S., Smith, A., Gravois, A., Reiners, E., Wu, X., Kilroy, G. E., LeFevre, M. L., & Gimble, J. M. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400198-mcp200 · Cited by 153 · see citing works

Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: A key to lean phenotype

Flachs, P., Rossmeisl, M., Kuda, O., & Kopecký, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.003 · Cited by 149 · see citing works

Mitochondrial function/dysfunction in white adipose tissue

Boudina, S., & Graham, T. E. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.081414 · Cited by 146 · see citing works

Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes

Tedesco, L., Valerio, A., Cervino, C., Cardile, A., Pagano, C., Vettor, R., Pasquali, R., Carruba, M. O., Marsicano, G., Lutz, B., et al. (2008) · Diabetes · doi:10.2337/db07-1623 · Cited by 145 · see citing works

Role of Lipotoxicity in Endothelial Dysfunction

Kim, J., Montagnani, M., Chandrasekran, S., & Quon, M. J. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.06.012 · Cited by 146 · see citing works

Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation

Seale, P. (2015) · Diabetes · doi:10.2337/db15-0203 · Cited by 143 · see citing works

Structural and Functional Consequences of Mitochondrial Biogenesis in Human Adipocytes<i>in Vitro</i>

Bogacka, I., Ukropcova, B., McNeil, M., Gimble, J. M., & Smith, S. R. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2005-1024 · Cited by 138 · see citing works

Mitochondrial fission‐fusion as an emerging key regulator of cell proliferation and differentiation

Mitra, K. (2013) · BioEssays · doi:10.1002/bies.201300011 · Cited by 132 · see citing works

Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARγ agonist

Petrovič, N., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00035.2008 · Cited by 134 · see citing works

Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation

Cardamone, M. D., Tanasă, B., Cederquist, C., Huang, J., Mahdaviani, K., Li, W., Rosenfeld, M. G., Liesa, M., & Perissi, V. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.01.037 · Cited by 134 · see citing works

Quantitative Proteomic Analysis of the Secretory Proteins from Rat Adipose Cells Using a 2D Liquid Chromatography−MS/MS Approach

Chen, X., Cushman, S. W., Pannell, L. K., & Hess, S. Y. (2005) · Journal of Proteome Research · doi:10.1021/pr049772a · Cited by 131 · see citing works

Apelin Attenuates Oxidative Stress in Human Adipocytes

Than, A., Zhang, X., Leow, M. K., Poh, C. L., Chong, S. K., & Chen, P. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.526210 · Cited by 126 · see citing works

Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients☆

Liu, J., Shen, W., Zhao, B., Wang, Y., Wertz, K., Weber, P., & Zhang, P. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.06.007 · Cited by 129 · see citing works

Adipocytes Targets and Actors in the Pathogenesis of HIV-Associated Lipodystrophy and Metabolic Alterations

Gougeon, M., Pénicaud, L., Fromenty, B., Leclercq, P., Viard, J., & Capeau, J. (2004) · Antiviral Therapy · doi:10.1177/135965350400900206 · Cited by 129 · see citing works

Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts.

Kim, B.-W., Choo, H.-J., Lee, J.-W., Kim, J.-H., & Ko, Y.-G. (2004) · Experimental &amp; Molecular Medicine · doi:10.1038/emm.2004.60 · Cited by 128 · see citing works

The Therapeutic Potential of Nuclear Receptor Modulators for Treatment of Metabolic Disorders: PPARγ, RORs, and Rev-erbs

Marciano, D. P., Chang, M. R., Corzo, C. A., Goswami, D., Lam, V. Q., Pascal, B. D., & Griffin, P. R. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.009 · Cited by 124 · see citing works

Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation

Woo, C.-Y., Jang, J. E., Lee, S. E., Koh, E. H., & Lee, K. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.0221 · Cited by 126 · see citing works

Oxidative Reactive Species in Cell Injury: Mechanisms in Diabetes Mellitus and Therapeutic Approaches

Fridlyand, L. E., & Philipson, L. H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1363.019 · Cited by 122 · see citing works

Rosiglitazone Treatment Prevents Mitochondrial Dysfunction in Mutant Huntingtin-expressing Cells

Quintanilla, R. A., Jin, Y. N., Fuenzalida, K. M., Bronfman, M., & Johnson, G. V. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804291200 · Cited by 126 · see citing works

Copper trafficking to the secretory pathway

Lutsenko, S. (2016) · Metallomics · doi:10.1039/c6mt00176a · Cited by 123 · see citing works

Small molecules for fat combustion: targeting obesity

Liu, J., Wang, Y., & Lin, L. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.09.007 · Cited by 123 · see citing works

Mitochondrial Dysfunction Mediates Aldosterone-Induced Podocyte Damage

Zhu, C., Huang, S., Yuan, Y., Ding, G., Chen, R., Liu, B., Yang, T., & Zhang, A. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.01.029 · Cited by 121 · see citing works

Calculation of ATP production rates using the Seahorse XF Analyzer

Desousa, B. R., Kim, K. K. O., Jones, A. E., Ball, A. B., Hsieh, W. Y., Swain, P. M., Morrow, D., Brownstein, A. J., Ferrick, D. A., Shirihai, O. S., et al. (2023) · EMBO Reports · doi:10.15252/embr.202256380 · Cited by 120 · see citing works

Mitochondrial dysfunction in insulin insensitivity: implication of mitochondrial role in type 2 diabetes

Wang, C., Ching-chū, W., & Wei, Y. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05625.x · Cited by 117 · see citing works

Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches

Sanchis‐Gomar, F., García‐Giménez, J. L., Gómez‐Cabrera, M. C., & Pallardó, F. V. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140306095106 · Cited by 117 · see citing works

Numerical Measurement of Viable and Nonviable Adipocytes and Other Cellular Components in Aspirated Fat Tissue

D, H. S. M., Matsumoto, D., Inoue, K., Shigeura, T., D, H. E. M., D, N. A. M., D, H. K. M., Abe, H., & Yoshimura, K. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e31817742ed · Cited by 118 · see citing works

Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders

Morris, G., Puri, B. K., Walker, A. J., Maes, M. H. J., Carvalho, A. F., Bortolasci, C. C., Walder, K. R., & Berk, M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.025 · Cited by 112 · see citing works

Epigenomic Deconvolution of Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types

Onuchic, V., Hartmaier, R. J., Boone, D. N., Samuels, M. L., Patel, R. Y., White, W., Garovic, V. D., Oesterreich, S., Roth, M. E., Lee, A. V., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.057 · Cited by 110 · see citing works

Mechanisms of obesity-induced metabolic and vascular dysfunctions

Caldwell, R. W. (2019) · Frontiers in bioscience · doi:10.2741/4758 · Cited by 112 · see citing works

Drug-induced lipotoxicity: Lipodystrophy associated with HIV-1 infection and antiretroviral treatment

Villarroya, F., Domingo, P., & Giralt, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.018 · Cited by 108 · see citing works

Tissue Immunometabolism: Development, Physiology, and Pathobiology

Man, K., Kutyavin, V. I., & Chawla, A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.016 · Cited by 107 · see citing works

Analysis of Mitochondrial Remodeling in Adipocytes during Adipogenesis and Obesity Development: a Dissertation

Wilson-Fritch, L. (2004) · eScholarship@UMassChan

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works

Alteration of mitochondria during adipocyte differentiation and mitochondrial dysfunction leads to insulin resistance of adipocytes

Wang, C., & Wei, Y. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.1226.40

doi:10.1155/2011/179454 Research Article Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated

T-l, M. (2016)

Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated Murine 3T3-L1 and C3H/10T1/2 Adipocytes

Rong, J. X., Klein, J.-L. D., Qiu, Y., Xie, M., Johnson, J. H., Waters, K. M., Zhang, V., Kashatus, J. A., Remlinger, K. S., Bing, N., et al. (2011) · PPAR Research · doi:10.1155/2011/179454 · Cited by 43 · see citing works