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Cited by 54Epigenetics and DNA MethylationAir Quality and Health ImpactsCarcinogens and Genotoxicity Assessment

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Increased methylation of repetitive elements and DNA repair genes is associated with higher DNA oxidation in children in an urbanized, industrial environment

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Alvarado-Cruz, Isabel, Sánchez-Guerra, Marco, Hernández-Cadena, Leticia, De Vizcaya-Ruiz, Andrea, Mugica, Violeta, Pelallo-Martínez, Nadia Azenet, Solís-Heredia, María de Jesús, Byun, Hyang-Min, Baccarelli, Andrea, Quintanilla-Vega, Betzabet·2017·Mutation Research/Genetic Toxicology and Environmental Mutagenesis
DOI 10.1016/j.mrgentox.2016.11.007
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Abstract

DNA methylation in DNA repair genes participates in the DNA damage regulation. Particulate matter (PM), which has metals and polycyclic aromatic hydrocarbons (PAHs) adsorbed, among others has been linked to adverse health outcomes and may modify DNA methylation. To evaluate PM exposure impact on repetitive elements and gene-specific DNA methylation and DNA damage, we conducted a cross-sectional study in 150 schoolchildren (7-10 years old) from an urbanized, industrial area of the metropolitan area of Mexico City (MAMC), which frequently exhibits PM concentrations above safety standards. Methylation (5mC) of long interspersed nuclear element-1 (LINE1) and DNA repair gene (OGG1, APEX, and PARP1) was assessed by pyrosequencing in peripheral mononuclear cells, DNA damage by comet assay and DNA oxidation by 8-OHdG content. PAH and metal contents in PM 10 (≤10μm aerodynamic diameter) were determined by HPLC-MS and ICP-AES, respectively. Multiple regression analysis between DNA methylation, DNA damage, and PM 10 exposure showed that PM 10 was significantly associated with oxidative DNA damage; a 1% increase in 5mC at all CpG sites in PARP1 promoter was associated with a 35% increase in 8-OHdG, while a 1% increase at 1, 2, and 3 CpG sites resulted in 38, 9, and 56% increments, respectively. An increase of 10pg/m 3 in benzo[b]fluoranthene content of PM 10 was associated with a 6% increase in LINE1 methylation. Acenaphthene, indene [1,2,3-cd] pyrene, and pyrene concentrations correlate…

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  • Maternal PM2.5 exposure has been correlated with overall placental DNA mutation rate, evidenced by an increased Alu rate and altered DNA methylation in promoter regions of key DNA repair and tumor suppressor genes including APEX1, ERCC4, DAPK, and PARP1.

    “Additionally, maternal PM2.5 exposure has been correlated with overall placental DNA mutation rate, evidenced by an increased Alu rate (as an estimate of global methylation [188]) and altered DNA methylation in the promoter regions of the key DNA repair and tumor suppressor genes including APEX1, ERCC4, DAPK, and PARP1 [189, 190].”

    From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [190]

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Metadata

Authors
Alvarado-Cruz, I., Sánchez-Guerra, M., Hernández-Cadena, L., De Vizcaya-Ruiz, A., Mugica, V., Pelallo-Martínez, N. A., Solís-Heredia, M. D. J., Byun, H.-M., Baccarelli, A., & Quintanilla-Vega, B.
Affiliations
  • Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
  • Harvard University (US)
ORCID
Venue
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Publisher
Elsevier BV
Published
2017-01
Volume
813
Pages
27-36
ISSN
1383-5718 (ISSN-L)
DOI
10.1016/j.mrgentox.2016.11.007
OpenAlex
W2549791663
Cited by
54
References
2
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 9 · 2017: 2
FWCI
3.81
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mutation Research/Genetic Toxicology and Environmental Mutagenesis (publishedVersion)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
National Institute of Environmental Health Sciences (R01ES020836, P30ES000002, R01ES021357)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords
DNA methylation, particulate matter, polycyclic aromatic hydrocarbons, vanadium, LINE-1, DNA repair genes, OGG1, APEX, PARP1, oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, children, industrial air pollution, Mexico City, CpG sites
MeSH terms
Child, Cross-Sectional Studies, DNA, DNA Repair, Environmental Exposure, Female, Humans, Male, Oxidation-Reduction, Repetitive Sequences, Nucleic Acid, Urban Population, DNA Methylation

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