CoChat
Sign Up
Cited by 130Growth Hormone and Insulin-like Growth FactorsFibroblast Growth Factor ResearchMetabolism, Diabetes, and Cancer

Insulin-like growth factor (IGF) axis in cancerogenesis

Kasprzak, Aldona, Kwasniewski, Wojciech, Adamek, Agnieszka, Gozdzicka-Jozefiak, Anna·2017·Mutation Research/Reviews in Mutation Research
DOI 10.1016/j.mrrev.2016.08.007
Open this paper in CoChat — free account

Abstract

Determination of the role of insulin-like growth factor (IGF) family components in carcinogenesis of several human tumors is based on numerous epidemiological and pre-clinical studies, experiments in vivo and in vitro and on attempts at application of drugs affecting the IGF axis. Investigative hypotheses in original studies were based on biological functions manifested by the entire family of IGF (ligands, receptors, linking proteins, adaptor molecules). In the context of carcinogenesis the most important functions of IGF family involve intensification of proliferation and inhibition of cell apoptosis and effect on cell transformation through synthesis of several regulatory proteins. IGF axis controls survival and influences on metastases of cells. Interactions of IGF axis components may be of a direct or indirect nature. The direct effects are linked to activation of PI3K/Akt signaling pathway, in which the initiating role is first of all played by IGF-1 and IGF-1R. Activity of this signaling pathway leads to an increased mitogenesis, cell cycle progression, and protection against different apoptotic stresses. Indirect effects of the axis depend on interactions between IGF and other molecules important for cancer etiology (e.g. sex hormones, products of suppressor genes, viruses, and other GFs) and the style of life (nutrition, physical activity). From the clinical point of view, components of IGF system are first of all considered as diagnostic serous and/or tissue biomarkers of a given cancer, prognostic factors and attractive target of modern anti-tumor therapies. Several mechanisms in which IGF system components act in the process of carcinogenesis need to be clarified, mainly due to multifactorial etiology of the neoplasms. Pin-pointing of the role played in carcinogenesis by any single signaling pathway remains particularly difficult. The aim of this review is to summarize the current data of several epidemiological studies, experiments in vitro and on animal models, to increase our understanding of the complex role of IGF family components in the most common human cancers.

Integrity signals

Registry

Crossref · 10.1016/j.mrrev.2016.08.007

Cites

404 of 404 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

2 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Kasprzak, A., Kwasniewski, W., Adamek, A., & Gozdzicka-Jozefiak, A.
Affiliations
Poznan University of Medical Sciences (PL)
Corresponding author
Kasprzak, Aldona
ORCID
Venue
Mutation Research/Reviews in Mutation Research
Publisher
Elsevier BV
Published
2017-04
Volume
772
Pages
78-104
ISSN
1383-5742 (ISSN-L)
DOI
10.1016/j.mrrev.2016.08.007
OpenAlex
W2517957586
Cited by
130
References
404
Citations by year
2026: 3 · 2025: 8 · 2024: 5 · 2023: 15 · 2022: 16 · 2021: 22 · 2020: 17 · 2019: 21 · 2018: 17 · 2017: 6
FWCI
2.16
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mutation Research/Reviews in Mutation Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
insulin-like growth factor, IGF axis, carcinogenesis, insulin-like growth factor I, IGF-1 receptor, PI3K/Akt signaling, cell proliferation, apoptosis inhibition, metastasis, tumor markers, prognostic factors, anti-tumor therapy, sex hormones, suppressor genes, lifestyle factors, human cancer
MeSH terms
Female, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Humans, Insulin-Like Growth Factor I, Lung Neoplasms, Phosphorylation, Skin Neoplasms, Meta-Analysis as Topic, Signal Transduction, Receptors, Somatomedin, Insulin-Like Growth Factor Binding Proteins, Papillomaviridae, Cell Line, Tumor, Carcinogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review