The DOI matches its Crossref record; 62 of the 64 references it cites were found in a registry or an index.
Anxiety and depression in Multiple Sclerosis (MS): Antecedents, consequences, and differential impact on well-being and quality of life
Open accessAbstract
Background Individuals with multiple sclerosis (MS) are often plagued by the unpredictability of their disease and have to contend with uncertainty in their life and significant life changes. This can lead to high levels of stress, perceived lack of control, helplessness, and anxiety. Despite these circumstances, anxiety disorders are often overshadowed by depression, which can result in its presence being overlooked and undertreated by many medical professionals. Methods One hundred and eighty three individuals with MS completed a comprehensive online survey assessing depression and anxiety and the demographic and disease risk factors of such, including social support and substance use. Participants also completed measures of MS symptomatology, disease management, psychological well-being, and quality of life to determine the impact of depression and anxiety on outcomes associated with MS. Results Findings suggest that both depression and anxiety are prevalent in MS and related to many outcomes. However, based on comparisons of the associations and group comparisons, with a few exceptions, anxiety proved to more impactful than depression when examining these outcomes. When evaluating the risk factors/contributors of anxiety and depression, social support was a consistent predictor. Younger age and shorter disease duration were also associated with anxiety, while lower education and substance use were predictors of depression. Conclusion Findings suggest that attention to anxiety be given as much as depression as it plays a large role in individuals' perceived health and well-being, which subsequently impacts the severity of symptoms and overall quality of life. Early identification of anxiety and potential substance use and increased social support also appear to be crucial for mitigating the impact of depression and anxiety.
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“Furthermore, individuals with MS are at a heightened risk for mental health disorders, such as depression and various forms of anxiety, including death anxiety (DA), which is characterized by intense feelings of terror, fear, or excessive worry regarding the process of dying, severing connection with the world, or uncertainties about what happens after death.”
From Comparing the Effects of Mindfulness-based Cognitive Therapy and Acceptance and Commitment Therapy on Quality of Life and Death Anxiety in Women With Multiple Sclerosis (2025) · cites this paper as [7]
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“These psychological disorders contribute to declined quality of life (QOL), which encompasses an individual's well-being, including physical, psychological, social, and environmental factors.”
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Items 201–206 of 206
Чи існує продромальна фаза розсіяного склерозу?
(2026) · Український медичний часопис · doi:10.32471/umj.1680-3051.279939
Venu, G., & Raj, S. S. B. (2026) · Indian Journal of Pharmacology · doi:10.4103/ijp.ijp_1266_25
“[4] People with MS experience increased anxiety, [5] locomotive enfeeblement [4] as well as altered brain chemicals, including decreased serotonin levels.”
Understanding neurological disorders
Ghosh, S., Pandey, A. K., Lamkuche, H. K., Singh, D. K. K., & Sinha, J. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36544-7.00005-7
Nakagawa, Y., & Yamada, S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06217-9
“…sclerosis patients, anxiety and depressed mood are positively associated with pain, physical disability, fatigue, and neurocognitive deficits, while these psychiatric symptoms negatively correlate with self-efficacy for disease management, psychological well-being, and quality of life [19, 20].”
A beacon of hope for tourists with anxiety and depression: Receiving support from animal friends
Lin, G., Li, M., Zhang, W., & Jiang, N. (2026) · Journal of Hospitality and Tourism Management · doi:10.1016/j.jhtm.2026.101573
Karaköse, Ş., Irmak, H. S., & Artan, T. (2026) · Journal of Health Psychology · doi:10.1177/13591053261497888
Metadata
- Authors
- Hanna, M., & Strober, L. B.
- Affiliations
- Montclair State University (US)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Strober, Lauren Beth
- ORCID
- Strober, Lauren Beth
- Venue
- Multiple Sclerosis and Related Disorders
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 44
- Pages
- 102261
- ISSN
- 2211-0348 (ISSN-L)
- PMC
- PMC7719086
- OpenAlex
- W3033947017
- Cited by
- 202
- References
- 64
- Citations by year
- 2026: 38 · 2025: 35 · 2024: 52 · 2023: 33 · 2022: 21 · 2021: 23
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Multiple Sclerosis and Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- multiple sclerosis, anxiety, depression, psychological well-being, quality of life, social support, substance use, disease duration, risk factors, symptom severity, early detection
- MeSH terms
- Anxiety, Anxiety Disorders, Depression, Humans, Multiple Sclerosis, Quality of Life
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