Cited by 64Multiple Sclerosis Research StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesCancer survivorship and care

The prevalence of anxiety and associated factors in persons with multiple sclerosis

Pham, Tram, Jetté, Nathalie, Bulloch, Andrew G.M., Burton, Jodie M., Wiebe, Samuel, Patten, Scott B.·2018·Multiple Sclerosis and Related Disorders

Abstract

Background The prevalence of anxiety and its association with sociodemographic and clinical factors is not well characterized in those with multiple sclerosis (MS). We aimed to estimate the prevalence and examine associated factors of anxiety in persons with MS.Methods A cross-sectional analysis was conducted utilizing data from 244 participants from the Neurological Disease and Depression study. Anxiety was assessed using the Hospital Anxiety and Depression Scale (HADS). Descriptive statistics and multiple logistic regression was used to examine anxiety and associated factors.Results Nearly 30.0% of participants had anxiety according to the HADS. The most prevalent symptom of anxiety was "worrying thoughts" (26.6%). After adjustment for various confounders, depression (OR: 7.31 95% CI 3.29-16.26) was found to be associated with higher odds of anxiety, while lower odds of anxiety were associated with higher education (OR: 0.51, 95% CI 0.28-0.94). Furthermore, anxiety was strongly associated with decreased quality of life.Conclusion Anxiety represents a substantial burden for those with MS and is associated with a variety of adverse outcomes including decreased quality of life. Our results further emphasize the importance of understanding the impact of anxiety in this population.

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Crossref · 10.1016/j.msard.2017.11.003

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Authors
Pham, T., Jetté, N., Bulloch, A. G. M., Burton, J. M., Wiebe, S., & Patten, S. B.
Affiliations
University of Calgary (CA)
Corresponding author
  • Pham, Tram
  • Bulloch, Andrew G.M.
  • Burton, Jodie M.
  • Wiebe, Samuel
  • Patten, Scott B.
Venue
Multiple Sclerosis and Related Disorders
Publisher
Elsevier BV
Published
2018-01
Volume
19
Pages
35-39
ISSN
2211-0348 (ISSN-L)
OpenAlex
W2765282886
Cited by
64
References
33
Citations by year
2026: 5 · 2025: 2 · 2024: 6 · 2023: 9 · 2022: 11 · 2021: 16 · 2020: 10 · 2019: 3 · 2018: 2
FWCI
5.89
Type
journal article
Language
en
Open access
closed
Locations
  • Multiple Sclerosis and Related Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Calgary Faculty of Medicine Team Grant Program
  • Canadian Institutes for Health Research
  • Alberta Health
  • University of Calgary Hotchkiss Brain Institute
  • Cumming School of Medicine
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords
multiple sclerosis, anxiety, prevalence, depression, quality of life, educational attainment, sociodemographic factors, clinical factors, Hospital Anxiety and Depression Scale
MeSH terms
Adult, Aged, Aged, 80 and over, Alberta, Anxiety, Cross-Sectional Studies, Depression, Educational Status, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Quality of Life, Comorbidity, Prevalence

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