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A study of the mechanical properties and cytocompatibility of lactide and caprolactone based scaffolds filled with inorganic bioactive particles
Abstract
The mechanical properties of highly porous (90% porosity) poly(l-lactide) (PLLA), poly(ε-caprolactone) (PCL) and poly(l-lactide/ε-caprolactone) (PLCL) were investigated. Young's modulus of non-porous PLLA, PCL and PLCL dropped from 2263.4, 183.7 and 5.7 MPa to 16.8, 1.0 and 1.0 MPa, respectively, for their ~90% porous counterparts. Elongation at break of PCL decreased noticeably with porosity fraction while PLCL maintained a highly elastomeric character and strain recovery capacity even in the presence of pores. Inorganic bioactive particles (hydroxyapatite or bioglass) were added to confer bioactivity to the aforementioned synthetic bioresorbable polymers, and their effect on the mechanical properties was also investigated. Addition of 15 vol.% of inorganic bioactive particles increased the Young's modulus of highly porous PLLA from 16.2 to ~30 MPa. On the contrary, the difference between Young's modulus of filled and unfilled PCL and PLCL scaffolds was not statistically significant. Finally, an in vitro study of the cytocompatibility and adhesion of adipose derived stem cells (ADSCs) was conducted. The observed viability and excellent adhesion of these cells to both porous and non-porous templates indicate that the employed materials can be good candidates for application in tissue engineering.
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High fracture elongation means PLCL can withstand large deformation without fracture and is suitable for flexible tissue engineering applications such as soft tissue scaffolds and vascular repair materials.
“The high fracture elongation means that PLCL is able to withstand large deformation without fracture in applications, and is suitable for tissue engineering applications that require flexibility, such as soft tissue scaffolds and vascular repair materials [59, 60].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [60]
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Metadata
- Authors
- Larrañaga, A., Diamanti, E., Rubio, E., Palomares, T., Alonso-Varona, A., Aldazabal, P., Martin, F. J., & Sarasua, J. R.
- Affiliations
- University of the Basque Country (ES)
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 42
- Pages
- 451-460
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2010890365
- Cited by
- 21
- References
- 44
- Citations by year
- 2026: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 7 · 2015: 3 · 2014: 1
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eusko Jaurlaritza
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- poly(L-lactic acid), polycaprolactone, poly(L-lactide-co-ε-caprolactone), porous scaffolds, bioactive particles, hydroxyapatite, bioactive glass, Young's modulus, elongation at break, strain recovery, cytocompatibility, adipose-derived stem cells, cell adhesion, tissue engineering, bioresorbable polymers
- MeSH terms
- Adipose Tissue, Biocompatible Materials, Caproates, Cell Adhesion, Cell Survival, Cells, Cultured, Dioxanes, Humans, Lactones, Materials Testing, Stem Cells, Porosity, Durapatite, Tissue Scaffolds, Elastic Modulus
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