Melt electrospinning of poly(ε-caprolactone) scaffolds: Phenomenological observations associated with collection and direct writing
Abstract
Melt electrospinning and its additive manufacturing analogue, melt electrospinning writing (MEW), are two processes which can produce porous materials for applications where solvent toxicity and accumulation in solution electrospinning are problematic. This study explores the melt electrospinning of poly(ε-caprolactone) (PCL) scaffolds, specifically for applications in tissue engineering. The research described here aims to inform researchers interested in melt electrospinning about technical aspects of the process. This includes rapid fiber characterization using glass microscope slides, allowing influential processing parameters on fiber morphology to be assessed, as well as observed fiber collection phenomena on different collector substrates. The distribution and alignment of melt electrospun PCL fibers can be controlled to a certain degree using patterned collectors to create large numbers of scaffolds with shaped macroporous architectures. However, the buildup of residual charge in the collected fibers limits the achievable thickness of the porous template through such scaffolds. One challenge identified for MEW is the ability to control charge buildup so that fibers can be placed accurately in close proximity, and in many centimeter heights. The scale and size of scaffolds produced using MEW, however, indicate that this emerging process will fill a technological niche in biofabrication.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Porosity of 3D biomaterial scaffolds and osteogenesis
Karageorgiou, V., & Kaplan, D. L. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.002 · Cited by 6,639 · see citing works
Electrospinning: A fascinating fiber fabrication technique
Bhardwaj, N., & Kundu, S. C. (2010) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.01.004 · Cited by 5,054 · see citing works
Subbiah, T., Bhat, G. S., Tock, R. W., Parameswaran, S., & Ramkumar, S. (2005) · Journal of Applied Polymer Science · doi:10.1002/app.21481 · Cited by 1,748 · see citing works
Bending instability in electrospinning of nanofibers
Yarin, A. L., Koombhongse, S., & Reneker, D. H. (2001) · Journal of Applied Physics · doi:10.1063/1.1333035 · Cited by 1,009 · see citing works
Taylor cone and jetting from liquid droplets in electrospinning of nanofibers
Yarin, A. L., Koombhongse, S., & Reneker, D. H. (2001) · Journal of Applied Physics · doi:10.1063/1.1408260 · Cited by 895 · see citing works
Direct writing by way of melt electrospinning
Brown, T. D., Dalton, P. D., & Hutmacher, D. W. (2011) · Advanced Materials · doi:10.1002/adma.201103482 · Cited by 800 · see citing works
Self-citationDesign, fabrication and characterization of PCL electrospun scaffolds—a review
Cipitria, A., Skelton, A., Dargaville, T. R., Dalton, P. D., & Hutmacher, D. W. (2011) · Journal of Materials Chemistry · doi:10.1039/c0jm04502k · Cited by 628 · see citing works
Self-citationThe thermal effects on electrospinning of polylactic acid melts
Zhou, H., Green, T. B., & Joo, Y. L. (2006) · Polymer · doi:10.1016/j.polymer.2006.08.042 · Cited by 400 · see citing works
Electrospinning of polymer melts: Phenomenological observations
Dalton, P. D., Grafahrend, D., Klinkhammer, K., et al. (2007) · Polymer · doi:10.1016/j.polymer.2007.09.037 · Cited by 361 · see citing works
Self-citationPolymeric Nanofibers in Tissue Engineering
Dahlin, R. L., Kasper, F. K., & Mikos, A. G. (2011) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2011.0238 · Cited by 343 · see citing works
Hutmacher, D. W., & Dalton, P. D. (2010) · Chemistry - An Asian Journal · doi:10.1002/asia.201000436 · Cited by 302 · see citing works
Self-citationDesign and Fabrication of Tubular Scaffolds via Direct Writing in a Melt Electrospinning Mode
Brown, T. D., Slotosch, A., Thibaudeau, L., Taubenberger, A. V., Loessner, D., Vaquette, C., Dalton, P. D., & Hutmacher, D. W. (2012) · Biointerphases · doi:10.1007/s13758-011-0013-7 · Cited by 299 · see citing works
Self-citationIncreasing the Pore Size of Electrospun Scaffolds
Rnjak‐Kovacina, J., & Weiss, A. S. (2011) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2011.0235 · Cited by 292 · see citing works
Electrospinning with dual collection rings
Dalton, P. D., Klee, D., & Möller, M. (2004) · Polymer · doi:10.1016/j.polymer.2004.11.075 · Cited by 277 · see citing works
Self-citationPatterning of Electrospun Fibers Using Electroconductive Templates
Zhang, D., & Chang, J. (2007) · Advanced Materials · doi:10.1002/adma.200700896 · Cited by 264 · see citing works
Electrospinning and additive manufacturing: converging technologies
Dalton, P. D., Vaquette, C., Farrugia, B. L., Dargaville, T. R., Brown, T. D., & Hutmacher, D. W. (2012) · Biomaterials Science · doi:10.1039/c2bm00039c · Cited by 263 · see citing works
Self-citationStructure and morphology of small diameter electrospun aramid fibers
Srinivasan, G., & Reneker, D. H. (1995) · Polymer International · doi:10.1002/pi.1995.210360210 · Cited by 261 · see citing works
Increasing electrospun scaffold pore size with tailored collectors for improved cell penetration
Vaquette, C., & Cooper-White, J. J. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.02.036 · Cited by 247 · see citing works
Agarwal, S., & Greiner, A. (2011) · Polymers for Advanced Technologies · doi:10.1002/pat.1883 · Cited by 216 · see citing works
Farrugia, B. L., Brown, T. D., Upton, Z., et al. (2013) · Biofabrication · doi:10.1088/1758-5082/5/2/025001 · Cited by 203 · see citing works
Self-citationSimonet, M., Schneider, O., Neuenschwander, P., & Stark, W. J. (2007) · Polymer Engineering and Science · doi:10.1002/pen.20914 · Cited by 193 · see citing works
Branching in electrospinning of nanofibers
Yarin, A. L., Kataphinan, W., & Reneker, D. H. (2005) · Journal of Applied Physics · doi:10.1063/1.2060928 · Cited by 189 · see citing works
Effect of culture conditions and calcium phosphate coating on ectopic bone formation
Vaquette, C., Ivanovski, S., Hamlet, S. M., & Hutmacher, D. W. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.088 · Cited by 164 · see citing works
Self-citationPatterned melt electrospun substrates for tissue engineering
Dalton, P. D., Joergensen, N. T., Gröll, J., & Möller, M. (2008) · Biomedical Materials · doi:10.1088/1748-6041/3/3/034109 · Cited by 154 · see citing works
Self-citationNagy, Z. K., Balogh, A., Drávavölgyi, G., et al. (2012) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23374 · Cited by 138 · see citing works
A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone
Thibaudeau, L., Taubenberger, A. V., Holzapfel, B. M., Quent, V. M. C., Führmann, T., Hesami, P., Brown, T. D., Dalton, P. D., Power, C. A., Hollier, B. G., et al. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.014076 · Cited by 136 · see citing works
Self-citationWei, C., & Dong, J. (2013) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/23/2/025017 · Cited by 129 · see citing works
Nayak, R., Padhye, R., Kyratzis, I. L., et al. (2012) · Textile Research Journal · doi:10.1177/0040517512458347 · Cited by 125 · see citing works
Melt electrospinning of poly‐(ethylene glycol‐block‐ϵ‐caprolactone)
Dalton, P. D., Calvet, J. L., Mourran, A., et al. (2006) · Biotechnology Journal · doi:10.1002/biot.200600064 · Cited by 108 · see citing works
Self-citationModeling of non-isothermal polymer jets in melt electrospinning
Zhmayev, E., Zhou, H., & Joo, Y. L. (2008) · Journal of Non-Newtonian Fluid Mechanics · doi:10.1016/j.jnnfm.2007.11.011 · Cited by 103 · see citing works
Scaffold Design and Fabrication
Hutmacher, D. W., Woodfield, T. B. F., & Dalton, P. D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-420145-3.00010-9 · Cited by 86 · see citing works
Self-citationMelt-electrospinning of polypropylene with conductive additives
Nayak, R., Kyratzis, I. L., Truong, Y. B., et al. (2012) · Journal of Materials Science · doi:10.1007/s10853-012-6563-3 · Cited by 85 · see citing works
Ko, J., Mohtaram, N. K., Ahmed, F., et al. (2013) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2013.830913 · Cited by 82 · see citing works
A unique device for controlled electrospinning
Mitchell, S. B., & Sanders, J. E. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30673 · Cited by 69 · see citing works
Characterization of gelatin nanofibers electrospun using ethanol/formic acid/water as a solvent
Chen, H., Jao, W., & Yang, M. (2008) · Polymers for Advanced Technologies · doi:10.1002/pat.1244 · Cited by 68 · see citing works
Wang, X., & Huang, Z. (2009) · Chinese Journal of Polymer Science · doi:10.1007/s10118-010-8208-9 · Cited by 61 · see citing works
Pendulum-like motion of straight electrified jets
Han, T., Reneker, D. H., & Yarin, A. L. (2008) · Polymer · doi:10.1016/j.polymer.2008.01.048 · Cited by 49 · see citing works
Erratum to: SnapShot: Polymer Scaffolds for Tissue Engineering [Biomaterials 30/4 (2009) 701–702]
Dalton, P. D., Woodfield, T. B. F., & Hutmacher, D. W. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.049 · Cited by 47 · see citing works
Self-citationFibrous star poly(ε-caprolactone) melt-electrospun scaffolds for wound healing applications
Gazzarri, M., Bartoli, C., Mota, C., et al. (2013) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911513494625 · Cited by 43 · see citing works
Exploitation of electric field in controlling of nanofiber spinning process
Heikkilä, P. R., Söderlund, L., Uusimäki, J., et al. (2007) · Polymer Engineering and Science · doi:10.1002/pen.20923 · Cited by 24 · see citing works
Electrospun Fibers for Drug Delivery
Cui, W., Chang, J., & Dalton, P. D. (2011) · Comprehensive Biomaterials · doi:10.1016/b978-0-08-055294-1.00151-3 · Cited by 20 · see citing works
Self-citationModulation of gene expression using electrospun scaffolds with templated architecture
Karchin, A., Wang, Y.-N., & Sanders, J. E. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34102 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering
Narayanan, G., Vernekar, V. N., Kuyinu, E. L., & Laurencin, C. T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.015 · Cited by 484 · see citing works
Felfel, R. M., Poocza, L., Gimeno-Fabra, M., Milde, T., Hildebrand, G., Ahmed, I., Scotchford, C., Sottile, V., Grant, D. M., & Liefeith, K. (2016) · Biomedical Materials · doi:10.1088/1748-6041/11/1/015011 · Cited by 103 · see citing works
- Authors
- Brown, T. D., Edin, F., Detta, N., Skelton, A. D., Hutmacher, D. W., & Dalton, P. D.
- Affiliations
- Queensland University of Technology (AU)
- Georgia Institute of Technology (US)
- Corresponding author
- Hutmacher, Dietmar W.
- Dalton, Paul D.
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 45
- Pages
- 698-708
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2116489560
- Cited by
- 170
- References
- 42
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 10 · 2023: 9 · 2022: 15 · 2021: 15 · 2020: 21 · 2019: 24 · 2018: 21 · 2017: 16 · 2016: 18 · 2015: 8 · 2014: 1
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Aerosol Filtration and Electrostatic Precipitation
- Keywords
- melt electrospinning, polycaprolactone, fiber scaffolds, tissue engineering scaffolds, fiber alignment, fiber morphology, biofabrication
- MeSH terms
- Biocompatible Materials, Humans, Microscopy, Electron, Scanning, Polyesters, Writing, Tissue Engineering, Tissue Scaffolds, Hydrodynamics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
