Cited by 48Nanoparticle-Based Drug DeliveryBarrier Structure and Function StudiesRNA Interference and Gene Delivery

Targeted transport of nanocarriers into brain for theranosis with rabies virus glycoprotein-derived peptide

Fu, Chen, Xiang, Yonggang, Li, Xiaorong, Fu, Ailing·2018·Materials Science and Engineering: C

Abstract

For successful theranosis of brain diseases, limited access of therapeutic molecules across blood-brain barrier (BBB) needs be overcome in brain delivery. Currently, peptide derivatives of rabies virus glycoprotein (RVG) have been exploited as delivery ligands to transport nanocarriers across BBB and specifically into the brain. The targeting peptides usually conjugate to the nanocarrier surface, and the cargoes, including siRNA, miRNA, DNA, proteins and small molecular chemicals, are complexed or encapsulated in the nanocarriers. The peptide ligand of the RVG-modified nanocarriers introduces the conjugated targeted-delivery into the brain, and the cargoes are involved in disease theranosis. The peptide-modified nanocarriers have been applied to diagnose and treat various brain diseases, such as glioma, Alzheimer's disease, ischemic injury, protein misfolding diseases etc. Since the targeting delivery system has displayed good biocompatibility and desirable therapeutic effect, it will raise a potential application in treating brain diseases.

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Crossref · 10.1016/j.msec.2017.12.029

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Authors
Fu, C., Xiang, Y., Li, X., & Fu, A.
Affiliations
  • Southwest University (CN)
  • Huazhong Agricultural University (CN)
Corresponding author
Fu, Ailing
Venue
Materials Science and Engineering: C
Publisher
Elsevier BV
Published
2018-06
Volume
87
Pages
155-166
ISSN
0928-4931 (ISSN-L)
OpenAlex
W2780134631
Cited by
48
References
81
Citations by year
2026: 5 · 2025: 8 · 2024: 3 · 2023: 10 · 2022: 4 · 2021: 11 · 2020: 2 · 2019: 4 · 2018: 1
FWCI
0.14
Type
journal article
Language
en
Open access
closed
Locations
  • Materials Science and Engineering C (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Science Foundation of China (81273416, 21601146)
  • China Postdoctoral Science Foundation (2015M582496)
  • Postdoctoral Science Foundation of Chongqing (Xm2016037)
  • Doctoral Fund of Southwest University (SWU114083)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
rabies virus glycoprotein, peptide ligands, blood-brain barrier, brain drug delivery, nanocarriers, targeted drug delivery, glioma, Alzheimer's disease, ischemic brain injury, proteinopathies, siRNA delivery, gene delivery
MeSH terms
Theranostic Nanomedicine, Animals, Blood-Brain Barrier, Brain Diseases, Drug Carriers, Glycoproteins, Humans, Peptides, Rabies virus, Viral Proteins

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