Targeted transport of nanocarriers into brain for theranosis with rabies virus glycoprotein-derived peptide
Abstract
For successful theranosis of brain diseases, limited access of therapeutic molecules across blood-brain barrier (BBB) needs be overcome in brain delivery. Currently, peptide derivatives of rabies virus glycoprotein (RVG) have been exploited as delivery ligands to transport nanocarriers across BBB and specifically into the brain. The targeting peptides usually conjugate to the nanocarrier surface, and the cargoes, including siRNA, miRNA, DNA, proteins and small molecular chemicals, are complexed or encapsulated in the nanocarriers. The peptide ligand of the RVG-modified nanocarriers introduces the conjugated targeted-delivery into the brain, and the cargoes are involved in disease theranosis. The peptide-modified nanocarriers have been applied to diagnose and treat various brain diseases, such as glioma, Alzheimer's disease, ischemic injury, protein misfolding diseases etc. Since the targeting delivery system has displayed good biocompatibility and desirable therapeutic effect, it will raise a potential application in treating brain diseases.
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RVG29 modification can significantly improve the targeting capability of EVs toward neurons both in vivo and in vitro compared to native EVs.
“RVG 29 modification can significantly improve the targeting capability of the EVs toward neurons both in vivo and in vitro, compared to native EVs [284, 285].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [284]
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- Authors
- Fu, C., Xiang, Y., Li, X., & Fu, A.
- Affiliations
- Southwest University (CN)
- Huazhong Agricultural University (CN)
- Corresponding author
- Fu, Ailing
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 87
- Pages
- 155-166
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2780134631
- Cited by
- 48
- References
- 81
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 3 · 2023: 10 · 2022: 4 · 2021: 11 · 2020: 2 · 2019: 4 · 2018: 1
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of China (81273416, 21601146)
- China Postdoctoral Science Foundation (2015M582496)
- Postdoctoral Science Foundation of Chongqing (Xm2016037)
- Doctoral Fund of Southwest University (SWU114083)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- rabies virus glycoprotein, peptide ligands, blood-brain barrier, brain drug delivery, nanocarriers, targeted drug delivery, glioma, Alzheimer's disease, ischemic brain injury, proteinopathies, siRNA delivery, gene delivery
- MeSH terms
- Theranostic Nanomedicine, Animals, Blood-Brain Barrier, Brain Diseases, Drug Carriers, Glycoproteins, Humans, Peptides, Rabies virus, Viral Proteins
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