Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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Transvascular delivery of small interfering RNA to the central nervous system

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Viral-genetic tracing of the input-output organization of a central noradrenaline circuit

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Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

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Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice

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Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors

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RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease

Cui, G.-H., Guo, H.-D., Li, H., Zhai, Y., Gong, Z.-B., Wu, J., Liu, J.-S., Dong, Y.-R., Hou, S.-X., & Liu, J.-R. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0150-2 · Cited by 305 · see citing works

MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice

Ying, W., Gao, H., Reis, F. C. G., Bandyopadhyay, G. K., Ofrecio, J. M., Luo, Z., Ji, Y., Jin, Z., Ly, C., & Olefsky, J. M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.019 · Cited by 303 · see citing works

Gut-educated IgA plasma cells defend the meningeal venous sinuses

Fitzpatrick, Z., Frazer, G. L., Ferro, A., Clare, S., Bouladoux, N. J., Ferdinand, J. R., Tuong, Z. K., Negro‐Demontel, M. L., Kumar, N., Suchánek, O., et al. (2020) · Nature · doi:10.1038/s41586-020-2886-4 · Cited by 297 · see citing works

Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

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Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

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Arginine or lysine in position 333 of ERA and CVS glycoprotein is necessary for rabies virulence in adult mice

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Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice

You, L., Wang, J., Liu, T., Zhang, Y., Han, X., Wang, T., Guo, S., Dong, T., Xu, J., Anderson, G. J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b08172 · Cited by 219 · see citing works

Antigenicity of rabies virus glycoprotein

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Cell penetrating peptides: the potent multi-cargo intracellular carriers

Kardani, K., Milani, A., Shabani, S. H., & Bolhassani, A. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1676720 · Cited by 199 · see citing works

Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer's disease mice

Yang, H. N., Gao, C., Wang, H., Sun, J., Liang, M., Feng, Y., Liu, Q., Fu, S., Cui, L., Gao, C., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.08.017 · Cited by 199 · see citing works

Concepts in the Pathogenesis of Rabies

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Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges

Gao, X., Li, L., Cai, X., Huang, Q., Xiao, J., & Cheng, Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120404 · Cited by 180 · see citing works

Gene Therapy for Drug-Resistant Glioblastoma via Lipid-Polymer Hybrid Nanoparticles Combined with Focused Ultrasound

Yang, Q., Zhou, Y., Chen, J., Huang, N., Wang, Z., & Cheng, Y. Z. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s286221 · Cited by 179 · see citing works

Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson’s disease

Liu, L., Li, Y., Peng, H., Liu, R., Ji, W., Shi, Z., Shen, J., Ma, G., & Zhang, X. (2020) · Science Advances · doi:10.1126/sciadv.aba3967 · Cited by 162 · see citing works

Dendrimer Brain Uptake and Targeted Therapy for Brain Injury in a Large Animal Model of Hypothermic Circulatory Arrest

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Nanotechnology and Nanocarrier-Based Drug Delivery as the Potential Therapeutic Strategy for Glioblastoma Multiforme: An Update

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Exosomes: Cell-Derived Nanoplatforms for the Delivery of Cancer Therapeutics

Kim, H., Kim, E. H., Kwak, G., Chi, S.-G., Kim, S. H., & Yang, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010014 · Cited by 147 · see citing works

Noninvasively immunogenic sonodynamic therapy with manganese protoporphyrin liposomes against triple-negative breast cancer

Chen, H., Liu, L., Ma, A., Yin, T., Chen, Z., Liang, R., Qiu, Y., Zheng, M., & Cai, L. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120639 · Cited by 144 · see citing works

Extensive Attenuation of Rabies Virus by Simultaneously Modifying the Dynein Light Chain Binding Site in the P Protein and Replacing Arg333 in the G Protein

Mebatsion, T. (2001) · Journal of Virology · doi:10.1128/jvi.75.23.11496-11502.2001 · Cited by 142 · see citing works

Enhanced BBB permeability of osmotically active poly(mannitol-co-PEI) modified with rabies virus glycoprotein via selective stimulation of caveolar endocytosis for RNAi therapeutics in Alzheimer's disease

Park, T., Singh, B., Li, H.-S., Lee, J.-Y., Kang, S., Choi, Y., & Cho, C. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.068 · Cited by 133 · see citing works

RVG29-Functionalized Lipid Nanoparticles for Quercetin Brain Delivery and Alzheimer’s Disease

Pinheiro, R. G. R., Granja, A., Loureiro, J. A., Pereira, M. D. C., Pinheiro, M., Neves, A. R., & Reis, S. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02865-1 · Cited by 133 · see citing works

Nanoparticles as carriers for drug delivery of macromolecules across the blood-brain barrier

Tosi, G., Duskey, J. T., & Kreuter, J. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1698544 · Cited by 129 · see citing works

Starch‐based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components

Yu, M., Ji, N., Wang, Y., Dai, L., Xiong, L., & Sun, Q. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12677 · Cited by 123 · see citing works

RVG-peptide-linked trimethylated chitosan for delivery of siRNA to the brain.

Gao, Y.-K., Wang, Z.-Y., Zhang, J.-H., Zhang, Y., Huo, H., Wang, T.-Y., Jiang, T., & Wang, S.-L. (2014) · Biomacromolecules · doi:10.1021/bm401906p · Cited by 121 · see citing works

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

Conceição, M., Mendonça, L., Nóbrega, C., Gomes, C., Costa, P., Hirai, H., Moreira, J. N., Lima, M. C., Manjunath, N., & Pereira de Almeida, L. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.021 · Cited by 117 · see citing works

Brain Targeted Gold Liposomes Improve RNAi Delivery for Glioblastoma

Grafals‐Ruiz, N., Ríos-Vicil, C. I., Lozada-Delgado, E. L., Quiñones‐Díaz, B. I., Rivera, R. A. N., Martínez-Zayas, G., Santana‐Rivera, Y., Santiago-Sánchez, G. S., Valiyeva, F., & Vivas‐Mejía, P. E. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s241055 · Cited by 110 · see citing works

Overcoming the Blood-Brain Barrier: Functionalised Chitosan Nanocarriers

Caprifico, A. E., Foot, P. J. S., Polycarpou, E., & Calabrese, G. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111013 · Cited by 108 · see citing works

Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases

Samaridou, E., Walgrave, H., Salta, E., Álvarez, D. M., Castro-López, V., Loza, M. I., & Alonso, M. J. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119657 · Cited by 98 · see citing works

Systemic delivery to central nervous system by engineered PLGA nanoparticles.

Cai, Q., Wang, L., Deng, G., Liu, J., Chen, Q., & Chen, Z. (2016) · PubMed Central · Cited by 97 · see citing works

Surface Modification of Nanoparticles for Targeted Drug Delivery

Pathak, Y. V. (2019) · Springer eBooks · doi:10.1007/978-3-030-06115-9 · Cited by 96 · see citing works

Precise genome engineering in Drosophila using prime editing

Bosch, J. A., Birchak, G., & Perrimon, N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021996118 · Cited by 94 · see citing works

Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke Therapy

Kim, M., Kim, G., Hwang, D. W., & Lee, M. (2019) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2019.2866 · Cited by 90 · see citing works

The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application

Rezaie, J., Aslan, C., Ahmadi, M., Zolbanin, N. M., Kashanchi, F., & Jafari, R. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00537-0 · Cited by 88 · see citing works

Biomimetic drug-delivery systems for the management of brain diseases

Chen, Y., Wei, C., Lyu, Y., Chen, H., Jiang, G., & Gao, X. (2019) · Biomaterials Science · doi:10.1039/c9bm01395d · Cited by 86 · see citing works

Mind the gap: from neurons to networks to outcomes in multiple sclerosis

the MAGNIMS Study Group, Chard, D., Alahmadi, A. A. S., Audoin, B., Charalambous, T., Enzinger, C., Hulst, H. E., Rocca, M. A., Rovira, À., Sastre‐Garriga, J., et al. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00439-8 · Cited by 86 · see citing works

Progress in the Application of Nanoparticles and Graphene as Drug Carriers and on the Diagnosis of Brain Infections

Barani, M., Mukhtar, M., Rahdar, A., Sargazi, G., Thysiadou, A. A., & Kyzas, G. Z. (2021) · Molecules · doi:10.3390/molecules26010186 · Cited by 84 · see citing works

Intranasal delivery of interferon-β-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy

González, L. F., Acuña, E., Arellano, G., Morales, P., Sotomayor, P. C., Oyarzun-Ampuero, F. A., & Naves, R. F. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.019 · Cited by 79 · see citing works

Nanoparticles as Adjuvants and Nanodelivery Systems for mRNA-Based Vaccines

Alfagih, I. M., Aldosari, B. N., AlQuadeib, B. T., Almurshedi, A. S., & Alfagih, M. M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics13010045 · Cited by 79 · see citing works

Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies

Elsenosy, F. M., Abdelbary, G. A., Elshafeey, A. H., Elsayed, I., & Fares, A. R. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s277352 · Cited by 77 · see citing works

Efficient neuronal targeting and transfection using RVG and transferrin-conjugated liposomes

Rodrigues, B. D. S., Arora, S., Kanekiyo, T., & Singh, J. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146738 · Cited by 74 · see citing works

MCH Neurons Regulate Permeability of the Median Eminence Barrier

Jiang, H., Gallet, S., Klemm, P., Scholl, P., Folz‐Donahue, K., Altmüller, J., Alber, J., Heilinger, C., Kukat, C., Loyens, A., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.04.020 · Cited by 74 · see citing works

Specific labeling of synaptic schwann cells reveals unique cellular and molecular features

Castro, R. W., Taetzsch, T., Doss, S. V., Godbe, K. N., Chappell, J. C., Settlage, R. E., & Valdez, G. (2020) · eLife · doi:10.7554/elife.56935 · Cited by 74 · see citing works

Rabies virus glycoprotein (RVG29)-linked microRNA-124-loaded polymeric nanoparticles inhibit neuroinflammation in a Parkinson’s disease model

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Targeted Delivery of Proteins into the Central Nervous System Mediated by Rabies Virus Glycoprotein-Derived Peptide

Fu, A., Wang, Y., Zhan, L., & Zhou, R. (2012) · Pharmaceutical Research · doi:10.1007/s11095-012-0667-y · Cited by 71 · see citing works

Functional peptide-based drug delivery systems

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Delivery of Anti‐microRNA‐712 to Inflamed Endothelial Cells Using Poly(β‐amino ester) Nanoparticles Conjugated with VCAM‐1 Targeting Peptide

Dosta, P., Tamargo, I. A., Ramos, V., Kumar, S., Kang, D. W., Borrós, S., & Jo, H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001894 · Cited by 71 · see citing works

Targeting Small Molecule Delivery to the Brain and Spinal Cord via Intranasal Administration of Rabies Virus Glycoprotein (RVG29)-Modified PLGA Nanoparticles

Chung, E. P., Cotter, J. D., Prakapenka, A. V., Cook, R. L., DiPerna, D. M., & Sirianni, R. W. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020093 · Cited by 69 · see citing works

Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: In vitro analysis

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Functionalized nanocarrier combined seizure-specific vector with P-glycoprotein modulation property for antiepileptic drug delivery

Liu, J., He, Y., Zhang, J., Li, J., Yu, X., Cao, Z., Meng, F., Zhao, Y., Wu, X., Shen, T., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.09.041 · Cited by 65 · see citing works

Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes

Zhao, M., Zhao, M., Fu, C., Yu, Y., & Fu, A. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s157019 · Cited by 62 · see citing works

Cell-penetrating peptides in oncologic pharmacotherapy: A review

Vale, N., Duarte, D., Silva, S., Correia, A. S., Costa, B., Gouveia, M. J., & Ferreira, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105231 · Cited by 59 · see citing works

The apelin/APJ system as a therapeutic target in metabolic diseases

Castan‐Laurell, I., Masri, B., & Valet, P. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1561871 · Cited by 55 · see citing works

Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses

Li, J., Liu, T., Dong, Y., Kondoh, K., & Lu, Z. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00374-9 · Cited by 54 · see citing works

Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging

Khaliq, N. U., Park, D. Y., Yun, B. M., Yang, D. H., Jung, Y. W., Seo, J. H., Hwang, C. S., & Yuk, S. H. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.11.064 · Cited by 54 · see citing works

Aptamer-Functionalized Dendrimer Delivery of Plasmid-Encoding lncRNA MEG3 Enhances Gene Therapy in Castration-Resistant Prostate Cancer

Tai, Z., Ma, J., Ding, J., Pan, H., Chai, R., Zhu, C., Cui, Z., Chen, Z., & Zhu, Q. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s282107 · Cited by 51 · see citing works

Penetration of blood–brain barrier and antitumor activity and nerve repair in glioma by doxorubicin-loaded monosialoganglioside micelles system

Zou, D., Wang, W., Lei, D., Yin, Y., Ren, P., Chen, J., Yin, T., Wang, B., Wang, G., & Wang, Y. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s138257 · Cited by 50 · see citing works

Neuroglia infection by rabies virus after anterograde virus spread in peripheral neurons

Potratz, M., Zaeck, L. M., Weigel, C., Klein, A. N., Freuling, C. M., Müller, T., & Finke, S. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01074-6 · Cited by 49 · see citing works

Targeted transport of nanocarriers into brain for theranosis with rabies virus glycoprotein-derived peptide

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Emerging roles of N- and C-terminally truncated Aβ species in Alzheimer’s disease

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Lung pathology due to hRSV infection impairs blood–brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS

Böhmwald, K., Soto, J. A., Andrade, C. A., Fernández‐Fierro, A., Espinoza, J. A., Ríos, M., Eugenín, E. A., González, P. A., Opazo, M. C., Riedel, C. A., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.021 · Cited by 43 · see citing works

Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis

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Polyion complex micelles composed of pegylated polyasparthydrazide derivatives for siRNA delivery to the brain

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Green nanomedicine: the path to the next generation of nanomaterials for diagnosing brain tumors and therapeutics?

Mostafavi, E., Medina-Cruz, D., Vernet-Crua, A., Chen, J., Cholula-Diaz, J. L., Guisbiers, G., & Webster, T. J. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1865306 · Cited by 38 · see citing works

MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics

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Cellular Uptake Mechanism and Therapeutic Utility of a Novel Peptide in Targeted-Delivery of Proteins into Neuronal Cells

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The necessity of diplomacy in brain health

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Targeted delivery of large fusion protein into hippocampal neurons by systemic administration

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Effective Gene Delivery into Human Stem Cells with a Cell-Targeting Peptide-Modified Bioreducible Polymer

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Metal-free semi-aromatic polyester as nanodrug carrier: A novel tumor targeting drug delivery vehicle for potential clinical application

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Rabies virus glycoprotein-amplified hierarchical targeted hybrids capable of magneto-electric penetration delivery to orthotopic brain tumor

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Lipid-based Nanocarriers for Cancer and Tumor Treatment

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Paclitaxel-loaded dextran nanoparticles decorated with RVG29 peptide for targeted chemotherapy of glioma: an in vivo study

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Surface-Modified PLGA Nanoparticles for Targeted Drug Delivery to Neurons

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Apolipoprotein E, low-density lipoprotein receptor, and immune cells control blood-brain barrier penetration by AAV-PHP.eB in mice

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Novel multi-stimuli responsive functionalized PEG-based co-delivery nanovehicles toward sustainable treatments of multidrug resistant tumor

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Multivalent Peptide-Functionalized Bioreducible Polymers for Cellular Delivery of Various RNAs

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Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca 2 + –CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

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Targeted CNS Delivery via Nanoparticulate Drug Delivery Systems

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RVG29-modified PAA-PEG nanocarriers enable synaptic cleft crossing and neuronal delivery

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