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Engineering a multifunctional 3D-printed PLA-collagen-minocycline-nanoHydroxyapatite scaffold with combined antimicrobial and osteogenic effects for bone regeneration
Abstract
3D-printing and additive manufacturing can be powerful techniques to design customized structures and produce synthetic bone grafts with multifunctional effects suitable for bone repair. In our work we aimed the development of novel multifunctionalized 3D printed poly(lactic acid) (PLA) scaffolds with bioinspired surface coatings able to reduce bacterial biofilm formation while favoring human bone marrow-derived mesenchymal stem cells (hMSCs) activity. For that purpose, 3D printing was used to prepare PLA scaffolds that were further multifunctionalized with collagen (Col), minocycline (MH) and bioinspired citrate- hydroxyapatite nanoparticles (cHA). PLA-Col-MH-cHA scaffolds provide a closer structural support approximation to native bone architecture with uniform macroporous, adequate wettability and an excellent compressive strength. The addition of MH resulted in an adequate antibiotic release profile that by being compatible with local drug delivery therapy was translated into antibacterial activities against Staphylococcus aureus, a main pathogen associated to bone-related infections. Subsequently, the hMSCs response to these scaffolds revealed that the incorporation of cHA significantly stimulated the adhesion, proliferation and osteogenesis-related gene expression (RUNX2, OCN and OPN) of hMSCs. Furthermore, the association of a bioinspired material (cHA) with the antibiotic MH resulted in a combined effect of an enhanced osteogenic activity. These findings, together with the antibiofilm activity depicted strengthen the appropriateness of this 3D-printed PLA-Col-MH-cHA scaffold for future use in bone repair. By targeting bone repair while mitigating the typical infections associated to bone implants, our 3D scaffolds deliver an integrated strategy with the combined effects further envisaging an increase in the success rate of bone-implanted devices.
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“Bioactive compound along with nano-HA/collagen enhanced the osteogenic properties and mechanical property.[107]”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [107]
Citations
Cites
Porosity of 3D biomaterial scaffolds and osteogenesis
Karageorgiou, V., & Kaplan, D. L. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.002 · Cited by 6,639
Farah, S., Anderson, D. G., & Langer, R. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.012 · Cited by 3,443
3D printing with polymers: Challenges among expanding options and opportunities
Stansbury, J. W., & Idacavage, M. J. (2015) · Dental Materials · doi:10.1016/j.dental.2015.09.018 · Cited by 1,758
Lebeaux, D., Ghigo, J., & Beloin, C. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00013-14 · Cited by 1,378
The significance of infection related to orthopedic devices and issues of antibiotic resistance
Campoccia, D., Montanaro, L., & Arciola, C. R. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.11.044 · Cited by 1,113
3D Printing of Scaffolds for Tissue Regeneration Applications
Do, A., Khorsand, B., Geary, S. M., & Salem, A. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500168 · Cited by 949
Minocycline: Far beyond an Antibiotic
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935
Bone biomaterials and interactions with stem cells
Gao, C., Peng, S., Feng, P., & Shuai, C. (2017) · Bone Research · doi:10.1038/boneres.2017.59 · Cited by 748
How microorganisms use hydrophobicity and what does this mean for human needs?
Krasowska, A., & Sigler, K. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00112 · Cited by 670
New insights into the biology of osteocalcin
Zoch, M. L., Clemens, T. L., & Riddle, R. C. (2015) · Bone · doi:10.1016/j.bone.2015.05.046 · Cited by 612
Flagged first, then by citations
Research works printed but not linked: 6
- Sung Eun, 2016, Biomed. Mater., 11
- Bae, 2018, Biomed. Res. Int., 12
- Tiago, 2017, Biomed. Mater., 12
- Oliveira, 2013, Adv. Mater. Sci. Eng., 14
- Xiao-Chen, 2011, Biomed. Mater., 6
- Dong, 2018, J. Biomed. Mater. Res. A, 1
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Naderi, S., & Esmaeili, A. (2021) · Research Square · doi:10.21203/rs.3.rs-547203/v1 · Cited by 1
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Metadata
- Authors
- Martin, V., Ribeiro, I. A., Alves, M. M., Gonçalves, L., Claudio, R. A., Grenho, L., Fernandes, M. H., Gomes, P., Santos, C. F., & Bettencourt, A. F.
- Affiliations
- University of Lisbon (PT)
- Universidade do Porto (PT)
- Corresponding author
- Santos, Catarina F.
- Bettencourt, Ana F.
- ORCID
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 101
- Pages
- 15-26
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2923561240
- Cited by
- 181
- References
- 59
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 32 · 2023: 25 · 2022: 26 · 2021: 39 · 2020: 30 · 2019: 4
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia (SFRH/BPD/76646/2011, UID/QUI/00100/2013, PT2020 UID/QUI/50006/2013, UID/DTP/04138/2014)
- Ministério da Educação e Ciência
- European Commission (POCI/01/0145/FEDER/007265)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Industrial and Manufacturing Engineering › Additive Manufacturing and 3D Printing Technologies
- Keywords
- 3D-printed scaffolds, polylactic acid, collagen, minocycline, bone regeneration, bone grafting, osteogenic differentiation, mesenchymal stem cells, antibacterial activity, biofilm inhibition, Staphylococcus aureus, antibiotic release, local drug delivery
- MeSH terms
- Adsorption, Anti-Bacterial Agents, Bone Regeneration, Collagen, Gene Expression Regulation, Humans, Microbial Sensitivity Tests, Minocycline, Osteogenesis, Polyesters, Staphylococcus aureus, Osseointegration, Durapatite, Biofilms, Tissue Engineering, Nanoparticles, Tissue Scaffolds, Mesenchymal Stem Cells, Drug Liberation, Printing, Three-Dimensional
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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