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Engineering a multifunctional 3D-printed PLA-collagen-minocycline-nanoHydroxyapatite scaffold with combined antimicrobial and osteogenic effects for bone regeneration
Abstract
3D-printing and additive manufacturing can be powerful techniques to design customized structures and produce synthetic bone grafts with multifunctional effects suitable for bone repair. In our work we aimed the development of novel multifunctionalized 3D printed poly(lactic acid) (PLA) scaffolds with bioinspired surface coatings able to reduce bacterial biofilm formation while favoring human bone marrow-derived mesenchymal stem cells (hMSCs) activity. For that purpose, 3D printing was used to prepare PLA scaffolds that were further multifunctionalized with collagen (Col), minocycline (MH) and bioinspired citrate- hydroxyapatite nanoparticles (cHA). PLA-Col-MH-cHA scaffolds provide a closer structural support approximation to native bone architecture with uniform macroporous, adequate wettability and an excellent compressive strength. The addition of MH resulted in an adequate antibiotic release profile that by being compatible with local drug delivery therapy was translated into antibacterial activities against Staphylococcus aureus, a main pathogen associated to bone-related infections. Subsequently, the hMSCs response to these scaffolds revealed that the incorporation of cHA significantly stimulated the adhesion, proliferation and osteogenesis-related gene expression (RUNX2, OCN and OPN) of hMSCs. Furthermore, the association of a bioinspired material (cHA) with the antibiotic MH resulted in a combined effect of an enhanced osteogenic activity. These findings, together with the antibiofilm activity depicted strengthen the appropriateness of this 3D-printed PLA-Col-MH-cHA scaffold for future use in bone repair. By targeting bone repair while mitigating the typical infections associated to bone implants, our 3D scaffolds deliver an integrated strategy with the combined effects further envisaging an increase in the success rate of bone-implanted devices.
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“Bioactive compound along with nano-HA/collagen enhanced the osteogenic properties and mechanical property.[107]”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [107]
Citations
Cites
Porosity of 3D biomaterial scaffolds and osteogenesis
Karageorgiou, V., & Kaplan, D. L. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.002 · Cited by 6,639
Farah, S., Anderson, D. G., & Langer, R. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.012 · Cited by 3,443
3D printing with polymers: Challenges among expanding options and opportunities
Stansbury, J. W., & Idacavage, M. J. (2015) · Dental Materials · doi:10.1016/j.dental.2015.09.018 · Cited by 1,758
Lebeaux, D., Ghigo, J., & Beloin, C. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00013-14 · Cited by 1,378
The significance of infection related to orthopedic devices and issues of antibiotic resistance
Campoccia, D., Montanaro, L., & Arciola, C. R. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.11.044 · Cited by 1,113
3D Printing of Scaffolds for Tissue Regeneration Applications
Do, A., Khorsand, B., Geary, S. M., & Salem, A. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500168 · Cited by 949
Minocycline: Far beyond an Antibiotic
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935
Bone biomaterials and interactions with stem cells
Gao, C., Peng, S., Feng, P., & Shuai, C. (2017) · Bone Research · doi:10.1038/boneres.2017.59 · Cited by 748
How microorganisms use hydrophobicity and what does this mean for human needs?
Krasowska, A., & Sigler, K. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00112 · Cited by 670
New insights into the biology of osteocalcin
Zoch, M. L., Clemens, T. L., & Riddle, R. C. (2015) · Bone · doi:10.1016/j.bone.2015.05.046 · Cited by 612
Flagged first, then by citations
Research works printed but not linked: 6
- Sung Eun, 2016, Biomed. Mater., 11
- Bae, 2018, Biomed. Res. Int., 12
- Tiago, 2017, Biomed. Mater., 12
- Oliveira, 2013, Adv. Mater. Sci. Eng., 14
- Xiao-Chen, 2011, Biomed. Mater., 6
- Dong, 2018, J. Biomed. Mater. Res. A, 1
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Balla, E. D., Daniilidis, V., Karlioti, G., Kalamas, T., Stefanidou, M., Bikiaris, N. D., Vlachopoulos, A., Koumentakou, I., & Bikiaris, D. Ν. (2021) · Polymers · doi:10.3390/polym13111822 · Cited by 697
Current applications of poly(lactic acid) composites in tissue engineering and drug delivery
Liu, S., Qin, S., He, M., Zhou, D., Qin, Q., & Wang, H. (2020) · Composites Part B: Engineering · doi:10.1016/j.compositesb.2020.108238 · Cited by 533
Zhu, G., Zhang, T., Chen, M., Yao, K., Huang, X., Zhang, B., Li, Y., Liu, J., Wang, Y., & Zhao, Z. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.043 · Cited by 516
Multifunctional antimicrobial materials: From rational design to biomedical applications
Duan, S., Wu, R., Xiong, Y., Ren, H., Lei, C., Zhao, Y., Zhang, X., & Xu, F. (2021) · Progress in Materials Science · doi:10.1016/j.pmatsci.2021.100887 · Cited by 260
Biomaterials and nanomedicine for bone regeneration: Progress and future prospects
Zhou, J. M., Zhang, Z., Joseph, J., Zhang, X., Ferdows, B. E., Patel, D. N., Chen, W., Banfi, G., Molinaro, R., Cosco, D., et al. (2021) · Exploration · doi:10.1002/exp.20210011 · Cited by 254
Feng, P., Jia, J., Liu, M., Peng, S., Zhao, Z., & Shuai, C. (2021) · Materials & Design · doi:10.1016/j.matdes.2021.110066 · Cited by 225
Polymeric and inorganic nanoscopical antimicrobial fillers in dentistry
Makvandi, P., Gu, J. T., Zare, E. N., Ashtari, B., Moeini, A., Tay, F. R., & Niu, L. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.09.025 · Cited by 199
Donate, R., Monzón, M., & Alemán‐Domínguez, M. E. (2020) · e-Polymers · doi:10.1515/epoly-2020-0046 · Cited by 175
Serrano‐Aroca, Á., Cano-Vicent, A., Serra, R. S. I., El‐Tanani, M., Aljabali, A. A. A., Tambuwala, M. M., & Mishra, Y. K. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100412 · Cited by 147
3D printing to innovate biopolymer materials for demanding applications: A review
Li, N., Qiao, D., Zhao, S., Lin, Q., Zhang, B., & Xie, F. (2021) · Materials Today Chemistry · doi:10.1016/j.mtchem.2021.100459 · Cited by 142
3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine
dos Santos, J., de Oliveira, R. S., de Oliveira, T. V., Velho, M. C., Konrad, M. V., da Silva, G. S., Deon, M., & Beck, R. C. R. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009691 · Cited by 146
On the progress of 3D-printed hydrogels for tissue engineering
Advíncula, R. C., Dizon, J. R. C., Caldona, E. B., Viers, R. A., Siacor, F. D. C., Maalihan, R. D., & Espera, A. H. (2021) · MRS Communications · doi:10.1557/s43579-021-00069-1 · Cited by 142
Zhang, X., Zhao, Y., Zhang, Y., Wang, A., Ding, X., Li, Y., Duan, S., Ding, X., & Xu, F. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b01060 · Cited by 134
Ahmad, A., BANAT, F. A., AlSafar, H. S., & Hasan, S. W. (2022) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-022-02581-3 · Cited by 144
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Zhou, J., See, C. W., Sreenivasamurthy, S., & Zhu, D. (2023) · Research · doi:10.34133/research.0239 · Cited by 115
Zheng, J., Zhao, H., Ouyang, Z., Zhou, X., Kang, J., Yang, C., Sun, C., Xiong, M., Fu, M., Jin, D., et al. (2021) · Composites Part B Engineering · doi:10.1016/j.compositesb.2021.109508 · Cited by 114
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Qin, D., Wang, N., You, X.-G., Zhang, A.-D., Chen, X., & Liu, Y. (2021) · Biomaterials Science · doi:10.1039/d1bm01294k · Cited by 113
Zheng, J., Zhao, H., Dong, E., Kang, J., Liu, C., Sun, C., Li, D., & Wang, L. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112333 · Cited by 106
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Surface modifications of scaffolds for bone regeneration
Teimouri, R., Abnous, K., Taghdisi, S. M., Ramezani, M., & Alibolandi, M. (2023) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2023.05.076 · Cited by 107
Anti-biofilm multi drug-loaded 3D printed hearing aids
Vivero-Lopez, M., Xu, X., Muras, A., Otero, A., Concheiro, Á., Gaisford, S., Basit, A. W., Alvarez‐Lorenzo, C., & Goyanes, Á. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111606 · Cited by 99
Kołodziejska, B., Kaflak, A., & Kolmas, J. (2020) · Materials · doi:10.3390/ma13071748 · Cited by 100
Domsta, V., & Seidlitz, A. (2021) · Molecules · doi:10.3390/molecules26134066 · Cited by 95
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Ashwin, B., Abinaya, B., Prasith, T. P., Chandran, S. V., Yadav, L. R., Vairamani, M., Patil, S., & Selvamurugan, N. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.157 · Cited by 92
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Muzzio, N., Moya, S. E., & Romero, G. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060792 · Cited by 93
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Cui, Y., Liu, H., Tian, Y., Fan, Y., Li, S., Wang, G., Wang, Y., Peng, C., & Wu, D. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100409 · Cited by 89
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Sobczak‐Kupiec, A., Drabczyk, A., Florkiewicz, W., Głąb, M., Kudłacik‐Kramarczyk, S., Słota, D., Tomala, A. M., & Tyliszczak, B. (2021) · Materials · doi:10.3390/ma14092096 · Cited by 84
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Milovanović, S. L., Pajnik, J., & Lukić, I. (2021) · Journal of Applied Polymer Science · doi:10.1002/app.51839 · Cited by 77
Cámara-Torres, M., Duarte, S., Sinha, R., Egizabal, A., Álvarez, N., Bastianini, M., Sisani, M., Scopece, P., Scatto, M., Bonetto, A., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.09.031 · Cited by 69
Advanced Hydrogel systems for mandibular reconstruction
Guo, J., Yao, H., Li, X., Chang, L., Wang, Z., Zhu, W., Su, Y., Qin, L., & Xu, J. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.08.001 · Cited by 68
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Kara, A., Distler, T., Polley, C., Schneidereit, D., Seitz, H., Friedrich, O., Tıhmınlıoğlu, F., & Boccaccini, A. R. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100309 · Cited by 65
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Kavitha Sri, A., Arthi, C., Neya, N. R., & Hikku, G. S. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99e · Cited by 57
Pecci, R., Baiguera, S., Ioppolo, P., Bedini, R., & Gaudio, C. D. (2019) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2019.103583 · Cited by 57
Nouri, A., Shirvan, A. R., Li, Y., & Wen, C. (2022) · Smart Materials in Manufacturing · doi:10.1016/j.smmf.2022.100001 · Cited by 54
Joseph, B., Ninan, N., Visalakshan, R. M., Denoual, C., Bright, R., Kalarikkal, N., Grohens, Y., Vasilev, K. A., & Thomas, S. (2020) · Composites Science and Technology · doi:10.1016/j.compscitech.2020.108544 · Cited by 54
Mustafa, N. S., Ngadiman, N. H. A., Izman, S., Talib, M. H. A., Shaiful, A. I. M., Omar, M. N. B., Zaiazmin, Y. N., & Illias, S. (2021) · Polymers · doi:10.3390/polym13101584 · Cited by 52
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Chen, C., Chen, C.-C., Wang, C., Lee, A. K.-X., Yeh, C.-L., & Lin, C. (2020) · Polymers · doi:10.3390/polym12071455 · Cited by 46
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Kim, S.-C., Heo, S., Oh, G., Yi, M., & Jung, W. (2022) · Marine Drugs · doi:10.3390/md20060344 · Cited by 41
Hu, X., Lin, Z., He, J., Zhou, M., Yang, S., Wang, Y., & Li, K. (2022) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.14 · Cited by 42
Yan, J., Lü, X., Zhu, X., Hu, X., Wang, L., Qian, J., Zhang, F., & Liu, M. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s228797 · Cited by 44
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Cardoso, P. H. N., & Araújo, E. S. (2024) · Compounds · doi:10.3390/compounds4010004 · Cited by 36
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Song, X., He, W., Qin, H., Yang, S., & Wen, S. (2020) · Materials · doi:10.3390/ma13020258 · Cited by 34
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Donate, R., Alemán‐Domínguez, M. E., & Monzón, M. (2021) · Polymers · doi:10.3390/polym13101643 · Cited by 30
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Rajabi, A., & Esmaeili, A. (2020) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2020.125508 · Cited by 24
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Shi, Q., Chen, J., Chen, J., Liu, Y., & Wang, H. (2024) · Biofabrication · doi:10.1088/1758-5090/ad35e8 · Cited by 23
Zheng, L., Tseomashko, N. E., Voronova, А. A., Vasil’kov, A. Y., Hu, X., & Wang, X. (2024) · Collagen and Leather · doi:10.1186/s42825-024-00164-8 · Cited by 25
Topuz, M., Topuz, F. C., Dikici, B., & Seifzadeh, D. (2025) · Journal of Applied Polymer Science · doi:10.1002/app.57321 · Cited by 22
Fu, Q., le Zhang, K., Fang, Z. W., Yang, M., Liu, M., Yang, R., Wang, Y., Yang, X. R., & Wang, Y. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061700 · Cited by 22
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Neto, A. S., Pereira, P., Fonseca, A. C., Días, C., Almeida, M. C., Barros, I., Miranda, C. O., de Almeida, L. P., Morais, P. V., Coelho, J. F. J., et al. (2021) · Polymers · doi:10.3390/polym13244378 · Cited by 19
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Kim, J., Park, S., Park, J., Jung, U., Jung, S.-W., Oh, Y., Lee, M., Heo, S., Choi, B., Cha, J., et al. (2024) · Nano Today · doi:10.1016/j.nantod.2023.102120 · Cited by 19
Jiang, C., Zhu, G., & Liu, Q. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1375266 · Cited by 22
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Donate, R., Alemán‐Domínguez, M. E., Monzón, M., Yu, J., Rodríguez‐Esparragón, F., & Liu, C. (2020) · Applied Sciences · doi:10.3390/app10072576 · Cited by 19
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Jahangiri, S., Rahimnejad, M., Boroujeni, N. N., Ahmadi, Z., Fath, P. M., Ahmadi, S., Safarkhani, M., & Rabiee, N. (2022) · The Journal of Gene Medicine · doi:10.1002/jgm.3458 · Cited by 19
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Chen, E., Wang, T., Sun, Z., Gu, Z., Xiao, S., & Ding, Y. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae058 · Cited by 19
Liu, F., Qu, W., Zhang, J., Liu, J., Zhu, Q., Yue, T., Xu, X., Ma, N., Ma, J., Sun, Y., et al. (2021) · Langmuir · doi:10.1021/acs.langmuir.1c00997 · Cited by 18
Preethi, A. M., & Bellare, J. (2021) · Frontiers in Materials · doi:10.3389/fmats.2020.594686 · Cited by 17
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Jiang, T., Su, W., Li, Y., Jiang, M., Zhang, Y., Xian, C. J., & Zhai, Y. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14080404 · Cited by 19
Metadata
- Authors
- Martin, V., Ribeiro, I. A., Alves, M. M., Gonçalves, L., Claudio, R. A., Grenho, L., Fernandes, M. H., Gomes, P., Santos, C. F., & Bettencourt, A. F.
- Affiliations
- University of Lisbon (PT)
- Universidade do Porto (PT)
- Corresponding author
- Santos, Catarina F.
- Bettencourt, Ana F.
- ORCID
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 101
- Pages
- 15-26
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2923561240
- Cited by
- 181
- References
- 59
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 32 · 2023: 25 · 2022: 26 · 2021: 39 · 2020: 30 · 2019: 4
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia (SFRH/BPD/76646/2011, UID/QUI/00100/2013, PT2020 UID/QUI/50006/2013, UID/DTP/04138/2014)
- Ministério da Educação e Ciência
- European Commission (POCI/01/0145/FEDER/007265)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Industrial and Manufacturing Engineering › Additive Manufacturing and 3D Printing Technologies
- Keywords
- 3D-printed scaffolds, polylactic acid, collagen, minocycline, bone regeneration, bone grafting, osteogenic differentiation, mesenchymal stem cells, antibacterial activity, biofilm inhibition, Staphylococcus aureus, antibiotic release, local drug delivery
- MeSH terms
- Adsorption, Anti-Bacterial Agents, Bone Regeneration, Collagen, Gene Expression Regulation, Humans, Microbial Sensitivity Tests, Minocycline, Osteogenesis, Polyesters, Staphylococcus aureus, Osseointegration, Durapatite, Biofilms, Tissue Engineering, Nanoparticles, Tissue Scaffolds, Mesenchymal Stem Cells, Drug Liberation, Printing, Three-Dimensional
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