A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer
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Previously used in anti-fungal therapy, itraconazole has now been shown to be successful in treating advanced breast cancer (NCT00798135). However, its poor solubility still restricts its application in clinical treatment. There is therefore an urgent need for combined methods to enhance the therapeutic effect of itraconazole (IC) in breast cancer treatment. With this goal, co-assembled IC/IR820 NPs with synergistic photonic hyperthermia and itraconazole payloads have been constructed to overcome these shortcomings. The IC/IR820 NPs show an enhanced therapeutic effect on breast cancer by inducing reactive oxygen species (ROS)-mediated apoptosis and autophagic death. Further evaluation in a mouse model has shown impressive effects of the IC/IR820 NPs on both inhibiting tumor metastasis and activating immunity to prevent tumor recurrence. Mechanistically, itraconazole may promote both tumor cell antigen presentation through autophagy and the activation of dendritic cells to induce an immune response, which displays a synergistic effect with the immune response generated by photothermal therapy to inhibit tumor recurrence. This strategy of combining itraconazole and IR820 into one minimalist and robust nanoplatform through co-assembly results in excellent therapeutic efficacy, suggesting its potential application as an alternative method for the clinical treatment of breast cancer.
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Co-assembling ITZ and IR820 into a single nanoplatform achieves excellent therapeutic efficacy and may be used as a substitute for current clinical breast cancer therapy techniques.
“Excellent therapeutic efficacy is achieved by co-assembling ITZ and IR820 into a single, robust, and minimalist nanoplatform, indicating that this approach may be used as a substitute for current clinical breast cancer therapy techniques.65”
From Itraconazole as a repurposed anti-cancer agent: focusing on synthesis, mechanisms of action and therapeutic insights (2026) · cites this paper as [65]
In a mouse model, IC/IR820 NPs prevented tumor spread and triggered immunity to stop tumor recurrence.
“Additional testing in a mouse model has demonstrated the remarkable effects of IC/IR820 NPs in preventing tumor spread and triggering immunity to stop tumor recurrence.”
From Itraconazole as a repurposed anti-cancer agent: focusing on synthesis, mechanisms of action and therapeutic insights (2026) · cites this paper as [65]
ITZ may stimulate dendritic cell activation and tumor cell antigen presentation via autophagy, eliciting an immunological response that works in concert with photothermal therapy to prevent tumor recurrence.
“Mechanistically, ITZ may stimulate dendritic cell activation and tumor cell antigen presentation via autophagy, eliciting an immunological response that works in concert with the immune response produced by photothermal therapy to prevent tumor recurrence.”
From Itraconazole as a repurposed anti-cancer agent: focusing on synthesis, mechanisms of action and therapeutic insights (2026) · cites this paper as [65]
IC/IR820 NPs have an improved therapeutic effect on breast cancer through ROS-mediated apoptosis and autophagic death.
“(ROS)-mediated apoptosis and autophagic death are two ways that the IC/IR820 NPs have an improved therapeutic effect on breast cancer.”
From Itraconazole as a repurposed anti-cancer agent: focusing on synthesis, mechanisms of action and therapeutic insights (2026) · cites this paper as [65]
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Tan, D., Wang, Y., Xu, C., & Wang, Y. (2026) · ACS Omega · doi:10.1021/acsomega.5c11050 · Cited by 2 · see citing works
Liu, J., Zhang, Q., He, L., Hu, H., Wang, Y., & Xie, P. (2025) · OncoTargets and Therapy · doi:10.2147/ott.s491310 · Cited by 2 · see citing works
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Self-citationTian, X., & Yang, H. (2026) · Open Life Sciences · doi:10.1515/biol-2025-1258
- Authors
- Ming, H., Li, B., Tian, H., Zhou, L., Jiang, J., Zhang, T., Qiao, L., Wu, P., Nice, E. C., Zhang, W., He, W., Huang, C., & Zhang, H.
- Affiliations
- Sichuan University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
- Monash University (AU)
- Army Medical University (CN)
- Yangtze University (CN)
- Corresponding author
- He, Weifeng
- Huang, Canhua
- Zhang, Haiyuan
- ORCID
- Venue
- Materials Today Bio
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 15
- Pages
- 100289
- ISSN
- 2590-0064 (ISSN-L)
- PMC
- PMC9130112
- OpenAlex
- W4280493953
- Cited by
- 33
- References
- 64
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 9
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials Today Bio (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (81790251, 81821002, 82130082)
- Sichuan University (ZYJC21004)
- National Key Research and Development Program of China
- National Key Research and Development Program of China Stem Cell and Translational Research (2020YFA0509400)
- Basic and Applied Basic Research Foundation of Guangdong Province (2019B030302012)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- itraconazole, IR820, breast cancer, photothermal therapy, autophagy, reactive oxygen species, apoptosis, cancer immunotherapy, dendritic cell activation, metastasis, tumor recurrence, drug solubility
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