Cited by 110Nanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsOptical Imaging and Spectroscopy Techniques

NIR‐II Organic Nanotheranostics for Precision Oncotherapy

Dai, Hanming, Wang, Xiaorui, Shao, Jinjun, Wang, Wenjun, Mou, Xiaozhou, Dong, Xiaochen·2021·Small

Abstract

Precision oncotherapy can remove tumors without causing any apparent iatrogenic damage or irreversible side effects to normal tissues. Second near‐infrared (NIR‐II) nanotheranostics can simultaneously perform diagnostic and therapeutic modalities in a single nanoplatform, which exhibits prominent perspectives in tumor precision treatment. Among all NIR‐II nanotheranostics, NIR‐II organic nanotheranostics have shown an exceptional promise for translation in clinical tumor treatment than NIR‐II inorganic nanotheranostics in virtue of their good biocompatibility, excellent reproducibility, desirable excretion, and high biosafety. In this review, recent progress of NIR‐II organic nanotheranostics with the integration of tumor diagnosis and therapy is systematically summarized, focusing on the theranostic modes and performances. Furthermore, the current status quo, problems, and challenges are discussed, aiming to provide a certain guiding significance for the future development of NIR‐II organic nanotheranostics for precision oncotherapy.

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Crossref · 10.1002/smll.202102646

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154 of 154 references verified0 citation errors · 0 not checkable

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  • For clinical translation, NIR-II probes must satisfy high biocompatibility, low toxicity, and favorable in vivo clearance profiles.

    “However, for successful clinical translation, NIR-II probes must satisfy rigorous requirements, such as high biocompatibility, low toxicity, and favorable in vivo clearance profiles59,60.”

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Authors
Dai, H., Wang, X., Shao, J., Wang, W., Mou, X., & Dong, X.
Affiliations
  • Nanjing Tech University (CN)
  • Liaocheng University (CN)
  • Zhejiang Provincial People's Hospital (CN)
Corresponding author
  • Shao, Jinjun
  • Mou, Xiaozhou
  • Dong, Xiaochen
Venue
Small
Publisher
Wiley
Published
2021-08-11
Volume
17
Issue
44
Pages
e2102646-e2102646
ISSN
  • 1613-6810 (ISSN-L)
  • 1613-6829
OpenAlex
W3188518633
Cited by
110
References
154
Citations by year
2026: 10 · 2025: 21 · 2024: 19 · 2023: 29 · 2022: 29 · 2021: 2
FWCI
1.67
Type
journal article
Language
en
Open access
closed
Locations
  • Small (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (61775095)
  • Natural Science Foundation of Jiangsu Province (BK20200092, Jiangsu Province Policy Guidance Plan, BZ2019014)
  • Natural Science Foundation of Shandong Province (ZR2020KB018)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Keywords
tumor diagnosis, cancer therapy, theranostic nanomaterials, biocompatibility, biosafety, excretion, anticancer drug delivery
MeSH terms
Theranostic Nanomedicine, Humans, Neoplasms, Phototherapy, Reproducibility of Results

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