NIR‐II Organic Nanotheranostics for Precision Oncotherapy
Abstract
Precision oncotherapy can remove tumors without causing any apparent iatrogenic damage or irreversible side effects to normal tissues. Second near‐infrared (NIR‐II) nanotheranostics can simultaneously perform diagnostic and therapeutic modalities in a single nanoplatform, which exhibits prominent perspectives in tumor precision treatment. Among all NIR‐II nanotheranostics, NIR‐II organic nanotheranostics have shown an exceptional promise for translation in clinical tumor treatment than NIR‐II inorganic nanotheranostics in virtue of their good biocompatibility, excellent reproducibility, desirable excretion, and high biosafety. In this review, recent progress of NIR‐II organic nanotheranostics with the integration of tumor diagnosis and therapy is systematically summarized, focusing on the theranostic modes and performances. Furthermore, the current status quo, problems, and challenges are discussed, aiming to provide a certain guiding significance for the future development of NIR‐II organic nanotheranostics for precision oncotherapy.
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For clinical translation, NIR-II probes must satisfy high biocompatibility, low toxicity, and favorable in vivo clearance profiles.
“However, for successful clinical translation, NIR-II probes must satisfy rigorous requirements, such as high biocompatibility, low toxicity, and favorable in vivo clearance profiles59,60.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [60]
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“However, for successful clinical translation, NIR-II probes must satisfy rigorous requirements, such as high bio-compatibility, low toxicity, and favorable in vivo clearance pro fi les 59,60 .”
- Authors
- Dai, H., Wang, X., Shao, J., Wang, W., Mou, X., & Dong, X.
- Affiliations
- Nanjing Tech University (CN)
- Liaocheng University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Corresponding author
- Shao, Jinjun
- Mou, Xiaozhou
- Dong, Xiaochen
- Venue
- Small
- Publisher
- Wiley
- Published
- 2021-08-11
- Volume
- 17
- Issue
- 44
- Pages
- e2102646-e2102646
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W3188518633
- Cited by
- 110
- References
- 154
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 19 · 2023: 29 · 2022: 29 · 2021: 2
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Small (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (61775095)
- Natural Science Foundation of Jiangsu Province (BK20200092, Jiangsu Province Policy Guidance Plan, BZ2019014)
- Natural Science Foundation of Shandong Province (ZR2020KB018)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- tumor diagnosis, cancer therapy, theranostic nanomaterials, biocompatibility, biosafety, excretion, anticancer drug delivery
- MeSH terms
- Theranostic Nanomedicine, Humans, Neoplasms, Phototherapy, Reproducibility of Results
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