Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing
Open accessAbstract
Cutaneous wound healing affecting millions of people worldwide represents an unsolvable clinical issue that is frequently challenged by scar formation with dramatical pain, impaired mobility and disfigurement. Herein, we prepared a kind of light-sensitive decellularized dermal extracellular matrix-derived hydrogel with fast gelling performance, biomimetic porous microstructure and abundant bioactive functions. On account of its excellent cell biocompatibility, this ECM-derived hydrogel could induce a marked cellular infiltration and enhance the tube formation of HUVECs. In vivo experiments based upon excisional wound splinting model showed that the hydrogel prominently imparted skin wound healing, as evidenced by notably increased skin appendages and well-organized collagen expression, coupled with significantly enhanced angiogenesis. Moreover, the skin regeneration mediated by this bioactive hydrogel was promoted by an accelerated M1-to-M2 macrophage phenotype transition. Consequently, the decellularized dermal matrix-derived bioactive hydrogel orchestrates the entire skin healing microenvironment to promote wound healing and will be of high value in treatment of cutaneous wound healing. As such, this biomimetic ddECMMA hydrogel provides a promising versatile opinion for the clinical translation.
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Studies on maxillofacial skin defect models have demonstrated that growth factor-loaded PDA hydrogels markedly promote angiogenesis and epithelialization, resulting in high-quality tissue repair outcomes.
“In particular, studies on maxillofacial skin defect models have demonstrated that growth factor–loaded PDA hydrogels markedly promote angiogenesis and epithelialization, resulting in high-quality tissue repair outcomes.57”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [57]
The Results and discussion sections on wound healing and angiogenesis report faster epithelial wound closure and increased vascularization with ddECMMA hydrogel; the Conclusion describes scar-free repair. But the model was rat full-thickness skin wounds, not maxillofacial defects, and the tested material was a dermal-matrix-derived ddECMMA hydrogel with retained growth factors, not a growth factor-loaded PDA hydrogel. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredCell culture, antibacterial adhesion assays, and mucosal/wound healing models indicate that PDA-based coatings or hydrogels can improve wet adhesion, antioxidative protection, localized drug delivery, inflammation regulation, and wound healing.
“Cell culture, antibacterial adhesion assays, and mucosal/wound healing models indicate that PDA-based coatings or hydrogels can improve wet adhesion, antioxidative protection, localized drug delivery, inflammation regulation, and wound healing.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [57]
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- Authors
- Yu, Y., Xiao, H., Tang, G., Wang, H., Shen, J., Sun, Y., Wang, S., Kong, W., Chai, Y., Liu, X., Wang, X., & Wen, G.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Shanghai Maritime University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Chai, Yimin
- Liu, Xuanzhe
- Wang, Xing
- Wen, Gen
- ORCID
- Venue
- Materials Today Bio
- Publisher
- Elsevier BV
- Published
- 2023-08
- Volume
- 21
- Pages
- 100725
- ISSN
- 2590-0064 (ISSN-L)
- PMC
- PMC10359665
- OpenAlex
- W4383559436
- Cited by
- 47
- References
- 49
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 20 · 2023: 1
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials Today Bio (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (51973226, 82002291)
- Shanghai Municipal Education Commission (201901070002E00043)
- Youth Innovation Promotion Association of the Chinese Academy of Sciences (2019031)
- National Key Research and Development Program of China (2020YFC2004900, 81930069)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- biomimetic hydrogels, skin wound healing, skin regeneration, angiogenesis, macrophage polarization, collagen expression, scar formation, HUVEC tube formation, excisional wound model
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