The immunology of the porcine skin and its value as a model for human skin
Open accessAbstract
The porcine skin has striking similarities to the human skin in terms of general structure, thickness, hair follicle content, pigmentation, collagen and lipid composition. This has been the basis for numerous studies using the pig as a model for wound healing, transdermal delivery, dermal toxicology, radiation and UVB effects. Considering that the skin also represents an immune organ of utmost importance for health, immune cells present in the skin of the pig will be reviewed. The focus of this review is on dendritic cells, which play a central role in the skin immune system as they serve as sentinels in the skin, which offers a large surface area exposed to the environment. Based on a literature review and original data we propose a classification of porcine dendritic cell subsets in the skin corresponding to the subsets described in the human skin. The equivalent of the human CD141(+) DC subset is CD1a(-)CD4(-)CD172a(-)CADM1(high), that of the CD1c(+) subset is CD1a(+)CD4(-)CD172a(+)CADM1(+/low), and porcine plasmacytoid dendritic cells are CD1a(-)CD4(+)CD172a(+)CADM1(-). CD209 and CD14 could represent markers of inflammatory monocyte-derived cells, either dendritic cells or macrophages. Future studies for example using transriptomic analysis of sorted populations are required to confirm the identity of these cells.
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Pig skin shares many characteristics with human skin, including similarities in the thickness of skin layers, the types and distribution of skin cells, and the mechanisms of skin repair.
“Pig skin was selected based on the many characteristics it shares with human skin, including similarities in the thickness of skin layers, the types and distribution of skin cells, and the mechanisms of skin repair (15–18).”
From Candida auris Forms High-Burden Biofilms in Skin Niche Conditions and on Porcine Skin (2020) · cites this paper as [18]
Porcine skin serves as an excellent model for studies of wound healing, infection, and skin colonization.
“In light of the similarities to human skin, porcine skin serves as an excellent model for studies of wound healing, infection, and skin colonization (15–18, 25).”
From Candida auris Forms High-Burden Biofilms in Skin Niche Conditions and on Porcine Skin (2020) · cites this paper as [18]
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- Authors
- Summerfield, A., Meurens, F., & Ricklin, M. E.
- Affiliations
- Institut für Virologie und Immunologie (CH)
- University of Saskatchewan (CA)
- Corresponding author
- Summerfield, Artur
- Venue
- Molecular Immunology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 66
- Issue
- 1
- Pages
- 14-21
- ISSN
- 0161-5890 (ISSN-L)
- OpenAlex
- W1988871156
- Cited by
- 551
- References
- 3
- Citations by year
- 2026: 66 · 2025: 70 · 2024: 59 · 2023: 55 · 2022: 59 · 2021: 45 · 2020: 60 · 2019: 48 · 2018: 23 · 2017: 34 · 2016: 21 · 2015: 10
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Immunology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by-nc-nd)
- Open Access CRIS of the University of Bern
- Funders
- European Union's Seventh Framework Programme (278433-PREDEMICS)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- porcine skin, skin immunology, dendritic cells, skin immune system, dendritic cell subsets, plasmacytoid dendritic cells, CD1a, SIRPα, CADM1, DC-SIGN, CD14, inflammatory monocytes, macrophages, skin as immune organ
- MeSH terms
- Animals, Antigens, Differentiation, Dendritic Cells, Disease Models, Animal, Humans, Macrophages, Monocytes, Plasma Cells, Skin, Skin Diseases, Swine
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