The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Negligible particle-specific toxicity mechanism of silver nanoparticles: The role of Ag+ ion release in the cytosol
Open accessAbstract
Toxicity of silver nanoparticles (AgNPs) is supported by many observations in literature, but no mechanism details have been proved yet. Here we confirm and quantify the toxic potential of fully characterized AgNPs in HeLa and A549 cells. Notably, through a specific fluorescent probe, we demonstrate the intracellular release of Ag(+) ions in living cells after nanoparticle internalization, showing that in-situ particle degradation is promoted by the acidic lysosomal environment. The activation of metallothioneins in response to AgNPs and the possibility to reverse the main toxic pathway by Ag(+) chelating agents demonstrate a cause/effect relationship between ions and cell death. We propose that endocytosed AgNPs are degraded in the lysosomes and the release of Ag(+) ions in the cytosol induces cell damages, while ions released in the cell culture medium play a negligible effect. These findings will be useful to develop safer-by-design nanoparticles and proper regulatory guidelines of AgNPs. From the clinical editor: The authors describe the toxic potential of silver nanoparticles (AgNP) in human cancer cell lines. Cell death following the application of AgNPs is dose-dependent, and it is mostly due to Ag+ ions. Further in vivo studies should be performed to gain a comprehensive picture of AgNP-toxicity in mammals.
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Cites
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Cited by
Ferdous, Z., & Nemmar, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072375 · Cited by 1,019
Yang, Y., Guo, L., Wang, Z., Liu, P., Liu, X., Ding, J., & Zhou, W. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120390 · Cited by 503
Marimuthu, S., Antonisamy, A. J., Malayandi, S., Rajendran, K., Tsai, P.-C., Pugazhendhi, A., & Ponnusamy, V. K. (2020) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2020.111823 · Cited by 429
Recent advances in green synthesized nanoparticles: from production to application
kazemi, S., Hosseingholian, A., Gohari, S. D., Feirahi, F., Moammeri, F., Mesbahian, G., Moghaddam, Z. S., & Ren, Q. (2023) · Materials Today Sustainability · doi:10.1016/j.mtsust.2023.100500 · Cited by 341
Metadata
- Authors
- De Matteis, V., Malvindi, M. A., Galeone, A., Brunetti, V., De Luca, E., Kote, S., Kshirsagar, P., Sabella, S., Bardi, G., & Pompa, P. P.
- Venue
- Nanomedicine: Nanotechnology, Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 11
- Issue
- 3
- Pages
- 731-739
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W1987386891
- Cited by
- 277
- References
- 56
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- green
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- De Matteis, V., Malvindi, M. A., Galeone, A., Brunetti, V., De Luca, E., Kote, S., Kshirsagar, P., Sabella, S., Bardi, G., & Pompa, P. P. (2015). Negligible particle-specific toxicity mechanism of silver nanoparticles: The role of Ag+ ion release in the cytosol. Nanomedicine: Nanotechnology, Biology and Medicine. https://doi.org/10.1016/j.nano.2014.11.002
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