The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration
Open accessAbstract
The mechanisms by which anti-Abeta antibodies clear amyloid plaques in Abeta depositing transgenic mice are unclear. In the current study, we demonstrate that inhibition of anti-Abeta antibody-induced microglial activation with anti-inflammatory drugs, such as dexamethasone, inhibits removal of fibrillar amyloid deposits. We also show that anti-Abeta F(ab')(2) fragments fail to activate microglia and are less efficient in removing fibrillar amyloid than the corresponding complete IgG. Diffuse Abeta deposits are cleared by antibodies under all circumstances. These data suggest that microglial activation is necessary for efficient removal of compact amyloid deposits with immunotherapy. Inhibition of this activation may result in an impaired clinical response to vaccination against Abeta.
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“This finding suggests that anti-apoE antibody might modulate similar inflammatory responses, which is consistent with the effect of certain anti-Aβ antibodies (Bard et al., 2000; Wilcock et al., 2004).”
From Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis (2012) · cites this paper as Wilcock et al., 2004
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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
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Immune attack: the role of inflammation in Alzheimer disease
Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134
Clearance systems in the brain—implications for Alzheimer disease
Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., Axel, L., Rusinek, H., Nicholson, C., Zlokovic, B. V., et al. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.119 · Cited by 1,678
Systemic infections and inflammation affect chronic neurodegeneration
Perry, V. H., Cunningham, C., & Holmes, C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2015 · Cited by 1,027
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Immune activation in brain aging and neurodegeneration: too much or too little?
Lucin, K. M., & Wyss-Coray, T. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.039 · Cited by 679
Metadata
- Authors
- Wilcock, D. M., Munireddy, S. K., Rosenthal, A., Ugen, K. E., Gordon, M. N., & Morgan, D.
- Affiliations
- University of South Florida (US)
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 15
- Issue
- 1
- Pages
- 11-20
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2063909850
- Cited by
- 202
- References
- 43
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 8 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 12 · 2014: 6 · 2013: 11 · 2012: 12
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG018478, AG 15490, R01AG020227, AG20227, R01AG015490, AG18478)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- microglial activation, amyloid plaques, plaque clearance, dexamethasone, anti-inflammatory agents, F(ab')2 fragments, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Anti-Inflammatory Agents, Antibodies, Brain, Dexamethasone, Disease Models, Animal, Encephalitis, Flurbiprofen, Gliosis, Immunoglobulin G, Mice, Transgenic, Peptide Fragments, Vaccines, Amyloid beta-Peptides, Leukocyte Common Antigens, Microglia, Mice, Plaque, Amyloid
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