Cited by 737Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

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Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study

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Turner, M.R, Cagnin, A, Turkheimer, F.E, Miller, C.C.J, Shaw, C.E, Brooks, D.J, Leigh, P.N, Banati, R.B·2004·Neurobiology of Disease

DOI 10.1016/j.nbd.2003.12.012

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Abstract

Microglial activation is implicated in the pathogenesis of ALS and can be detected in animal models of the disease that demonstrate increased survival when treated with anti-inflammatory drugs. PK11195 is a ligand for the "peripheral benzodiazepine binding site" expressed by activated microglia. Ten ALS patients and 14 healthy controls underwent [(11)C](R)-PK11195 PET of the brain. Volumes of interest were defined to obtain [(11)C](R)-PK11195 regional binding potential values for motor and "extra-motor" regions. Significantly increased binding was found in motor cortex (P = 0.003), pons (P = 0.004), dorsolateral prefrontal cortex (P = 0.010) and thalamus (P = 0.005) in the ALS patients, with significant correlation between binding in the motor cortex and the burden of upper motor neuron signs clinically (r = 0.73, P = 0.009). These findings indicate that cerebral microglial activation can be detected in vivo during the evolution of ALS, and support the previous observations that cerebral pathology is widespread. They also argue for the development of therapeutic strategies aimed at inflammatory pathways.

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Brooks, B. R., Miller, R. G., Swash, M., & Munsat, T. L. (2000) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/146608200300079536 · Cited by 5,433
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,400
The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function
Cedarbaum, J. M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., & Nakanishi, A. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00210-5 · Cited by 3,307
Simplified Reference Tissue Model for PET Receptor Studies
Lammertsma, A. A., & Hume, S. P. (1996) · NeuroImage · doi:10.1006/nimg.1996.0066 · Cited by 2,025
Amyotrophic Lateral Sclerosis
Rowland, L. P., & Shneider, N. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105313442207 · Cited by 1,913
From charcot to lou gehrig: deciphering selective motor neuron death in als
Cleveland, D. W., & Rothstein, J. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097565 · Cited by 1,389
Parametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model
Gunn, R. N., Lammertsma, A. A., Hume, S. P., & Cunningham, V. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0303 · Cited by 1,085
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,069
In-vivo measurement of activated microglia in dementia
Cagnin, A., Brooks, D. J., Kennedy, A. M., Gunn, R. N., Myers, R., Turkheimer, F. E., Jones, T., & Banati, R. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05625-2 · Cited by 1,054
Self-citation
The overlap of amyotrophic lateral sclerosis and frontotemporal dementia
Lomen, C. E., Anderson, T. T., & Miller, B. L. (2002) · Neurology · doi:10.1212/wnl.59.7.1077 · Cited by 699
The peripheral benzodiazepine binding site in the brain in multiple sclerosis
Banati, R. B., Newcombe, J., Gunn, R. N., Cagnin, A., Turkheimer, F., Heppner, F., Price, G., Wegner, F., Giovannoni, G., Miller, D. H., et al. (2000) · Brain · doi:10.1093/brain/123.11.2321 · Cited by 661
Self-citation
Microglia in degenerative neurological disease
McGeer, P. L., Kawamata, T., Walker, D. G., Akiyama, H., Tooyama, I., & McGeer, E. G. (1993) · Glia · doi:10.1002/glia.440070114 · Cited by 596
Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.
Kawamata, T., Akiyama, H., Yamada, T., & McGeer, P. L. (1992) · PubMed Central · Cited by 546
Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis
Kostić, V., Jackson-Lewis, V. R., de Bilbao, F., Dubois‐Dauphin, M., & Przedborski, S. (1997) · Science · doi:10.1126/science.277.5325.559 · Cited by 477
Inflammatory processes in amyotrophic lateral sclerosis
McGeer, P. L., & McGeer, E. G. (2002) · Muscle & Nerve · doi:10.1002/mus.10191 · Cited by 470
Immune reactivity in a mouse model of familial ALS correlates with disease progression
Alexianu, M. E., Kozovska, M., & Appel, S. H. (2001) · Neurology · doi:10.1212/wnl.57.7.1282 · Cited by 438
Motoneuron Death Triggered by a Specific Pathway Downstream of Fas
Raoul, C., Estévez, Á. G., Nishimune, H., Cleveland, D. W., deLapeyrière, O., Henderson, C. E., Haase, G., & Pettmann, B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00905-4 · Cited by 432
Visualising microglial activation in vivo
Banati, R. B. (2002) · Glia · doi:10.1002/glia.10144 · Cited by 428
Self-citation
Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS)
Abrahams, S., Leigh, P. N., Harvey, A., Vythelingum, G. N., Grisé, D., & Goldstein, L. H. (2000) · Neuropsychologia · doi:10.1016/s0028-3932(99)00146-3 · Cited by 427
Self-citation
Minocycline Slows Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis
Križ, J., Nguyen, M. D., & Julien, J. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0487 · Cited by 411
Diffusion tensor MRI assesses corticospinal tract damage in ALS
Ellis, C. M., Simmons, A., Jones, D. K., Bland, J. D. P., Dawson, J. M., Horsfield, M. A., Williams, S., & Leigh, P. N. (1999) · Neurology · doi:10.1212/wnl.53.5.1051 · Cited by 394
Self-citation
A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis
Borasio, G. D., Robberecht, W., Leigh, P. N., Emile, J., Guiloff, R. J., Jerusalem, F., Silani, V., Vos, P. E., Wokke, J. H. J., Dobbins, T., et al. (1998) · Neurology · doi:10.1212/wnl.51.2.583 · Cited by 339
Self-citation
Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis
Engelhardt, J. I., Tajti, J., & Appel, S. H. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540010026013 · Cited by 318
Frontal lobe function in amyotrophic lateral sclerosis: a neuropsychologic and positron emission tomography study
Ludolph, A. C., Langen, K., Regard, M., Herzog, H. R., Kemper, B., Kuwert, T., Böttger, I. G., & Feinendegen, L. E. (1992) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1992.tb04003.x · Cited by 309
Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS
Drachman, D. B., Frank, K., Dykes‐Hoberg, M., Teismann, P., Almer, G., Przedborski, S., & Rothstein, J. D. (2002) · Annals of Neurology · doi:10.1002/ana.10374 · Cited by 307
Corticospinal tract degeneration in the progressive muscular atrophy variant of ALS
Ince, P. G., Evans, J., Knopp, M. V., Forster, G., Hamdalla, H. H. M., Wharton, S. B., & Shaw, P. J. (2003) · Neurology · doi:10.1212/01.wnl.0000058901.75728.4e · Cited by 303
Minocycline delays disease onset and mortality in a transgenic model of ALS
Bosch, L. V. D., Tilkin, P., Lemmens, G., & Robberecht, W. (2002) · Neuroreport · doi:10.1097/00001756-200206120-00018 · Cited by 297
PK (‘peripheral benzodiazepine’) – binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK 11195 binding to activated microglia
Banati, R. B., Myers, R., & Kreutzberg, G. W. (1997) · Journal of Neurocytology · doi:10.1023/a:1018567510105 · Cited by 296
Self-citation
Labelling of “Peripheral‐Type” Benzodiazepine Binding Sites in the Rat Brain By Using [3H]PK 11195, an Isoquinoline Carboxamide Derivative: Kinetic Studies and Autoradiographic Localization
Bénavidès, J., Quarteronet, D., Imbault, F., Malgouris, C., Uzan, A., Renault, C., Dubroeucq, M. C., Gueremy, C., & Fur, G. L. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb00888.x · Cited by 289
Frontal lobe dysfunction in amyotrophic lateral sclerosis
Abrahams, S., Goldstein, L. H., Kew, J., Brooks, D. J., Lloyd, C., Frith, C., & Leigh, P. N. (1996) · Brain · doi:10.1093/brain/119.6.2105 · Cited by 276
Self-citation
Immune Surveillance in the Injured Nervous System: T-Lymphocytes Invade the Axotomized Mouse Facial Motor Nucleus and Aggregate around Sites of Neuronal Degeneration
Raivich, G., Jones, L. L., Kloss, C. U. A., Werner, A., Neumann, H., & Kreutzberg, G. W. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-15-05804.1998 · Cited by 273
Cortical function in amyotrophic lateral sclerosis
Kew, J., Leigh, P. N., Playford, E. D., Passingham, R. E., Goldstein, L. H., Frackowiak, R. S. J., & Brooks, D. J. (1993) · Brain · doi:10.1093/brain/116.3.655 · Cited by 261
Self-citation
Thalamic microglial activation in ischemic stroke detected in vivo by PET and [ 11 C]PK11195
Pappatà, S., Levasseur, M., Gunn, R. N., Myers, R., Crouzel, C., Syrota, A., Jones, T., Kreutzberg, G. W., & Banati, R. B. (2000) · Neurology · doi:10.1212/wnl.55.7.1052 · Cited by 252
Self-citation
Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis.
Massman, P. J., Sims, J., Cooke, N., Haverkamp, L. J., Appel, V., & Appel, S. H. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.61.5.450 · Cited by 251
[ 11 C]( R )-PK11195 PET imaging of microglial activation in multiple system atrophy
Gerhard, A., Banati, R. B., Goerres, G. B., Cagnin, A., Myers, R., Gunn, R. N., Turkheimer, F., Good, C. D., Mathias, C. J., Quinn, N. P., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000078192.95645.e6 · Cited by 247
Self-citation
Late Onset Death of Motor Neurons in Mice Overexpressing Wild-Type Peripherin
Beaulieu, J., Nguyen, M. D., & Julien, J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.531 · Cited by 240
Amyotrophic lateral sclerosis (ALS): A phylogenetic disease of the corticomotoneuron?
Eisen, A., Kim, S. U., & Pant, B. (1992) · Muscle & Nerve · doi:10.1002/mus.880150215 · Cited by 239
[ 11 C] (R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen’s encephalitis
Banati, R. B., Goerres, G. W., Myers, R., Gunn, R. N., Turkheimer, F. E., Kreutzberg, G. W., Brooks, D. J., Jones, T., & Duncan, J. S. (1999) · Neurology · doi:10.1212/wnl.53.9.2199 · Cited by 224
Self-citation
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders
Cochran, E. J. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.2.182 · Cited by 214
Neuropathology with Clinical Correlations of Sporadic Amyotrophic Lateral Sclerosis: 102 Autopsy Cases Examined Between 1962 and 2000
Piao, Y., Wakabayashi, K., Kakita, A., Yamada, M., Hayashi, S., Morita, T., Ikuta, F., Oyanagi, K., & Takahashi, H. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00002.x · Cited by 210
Neuroprotective effects of non‐steroidal anti‐inflammatory drugs by direct scavenging of nitric oxide radicals
Asanuma, M., Nishibayashi-Asanuma, S., Miyazaki, I., Kohno, M., & Ogawa, N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00205.x · Cited by 190
Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression
Tortarolo, M., Veglianese, P., Calvaresi, N., Botturi, A., Rossi, C., Giorgini, A., Migheli, A., & Bendotti, C. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00022-8 · Cited by 180
Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS
Ellis, C. M., John Suckling, A., Amaro, E., Bullmore, E. T., Simmons, A., Williams, S., & Leigh, P. N. (2001) · Neurology · doi:10.1212/wnl.57.9.1571 · Cited by 178
Self-citation
Extramotor involvement in ALS: PET studies with the GABAA ligand [11C]flumazenil
Lloyd, C., Richardson, M. P., Brooks, D. J., Al‐Chalabi, A., & Leigh, P. N. (2000) · Brain · doi:10.1093/brain/123.11.2289 · Cited by 178
Self-citation
In vivo visualization of activated glia by[11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion
Cagnin, A. (2001) · Brain · doi:10.1093/brain/124.10.2014 · Cited by 169
Self-citation
Reactive Astrogliosis is Widespread in the Subcortical White Matter of Amyotrophic Lateral Sclerosis Brain
Kushner, P. D., Stephenson, D. T., & Wright, S. (1991) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199105000-00008 · Cited by 166
Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis
Akiyama, H., Nishimura, T., Kondo, H., Ikeda, K., Hayashi, Y., & McGeer, P. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)91779-5 · Cited by 162
Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions.
McGeer, P. L., & McGeer, E. G. (1998) · PubMed · Cited by 157
Transformation of donor‐derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy
Flügel, A., Bradl, M., Kreutzberg, G. W., & Graeber, M. B. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1198 · Cited by 155
Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis
Troost, D., van den Oord, J. J., & de Jong, J. M. B. V. (1990) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1990.tb01276.x · Cited by 153
Marked increase in cyclooxygenase-2 in ALS spinal cord
Yasojima, K., Tourtellotte, W. W., McGeer, E. G., & McGeer, P. L. (2001) · Neurology · doi:10.1212/wnl.57.6.952 · Cited by 147
Prolonged survival in motor neuron disease: a descriptive study of the King's database 1990-2002
Turner, M. R. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.7.995 · Cited by 147
Self-citation
A therapeutic role for cyclooxygenase‐2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis
Pompl, P. N., Ho, L., Bianchi, M., McManus, T. E., Qin, W., & Pasinetti, G. M. (2003) · The FASEB Journal · doi:10.1096/fj.02-0876fje · Cited by 144
In vivo imaging of activated microglia using [11 C]PK11195 and positron emission tomography in patients after ischemic stroke
Gerhard, A., Neumaier, B., Elitok, E., Glatting, G., Ries, V., Tomczak, R. J., Ludolph, A. C., & Reske, S. N. (2000) · Neuroreport · doi:10.1097/00001756-200009110-00025 · Cited by 136
Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease
Tikka, T., Vartiainen, N. E., Goldsteins, G., Oja, S. S., Andersen, P. M., Marklund, S. L., & Koıstınaho, J. (2002) · Brain · doi:10.1093/brain/awf068 · Cited by 136
Recent advances in amyotrophic lateral sclerosis
Al‐Chalabi, A., & Leigh, P. N. (2000) · Current Opinion in Neurology · doi:10.1097/00019052-200008000-00006 · Cited by 135
Self-citation
Efficient three‐drug cocktail for disease induced by mutant superoxide dismutase
Križ, J., Gowing, G., & Julien, J. (2003) · Annals of Neurology · doi:10.1002/ana.10500 · Cited by 133
Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis
Nagy, D., Kato, T., & Kushner, P. D. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490380312 · Cited by 131
Issues & Opinions: Amyotrophic lateral sclerosis: Lower motor neuron disease spreading to upper motor neurons
Chou, S. M., & Norris, F. H. (1993) · Muscle & Nerve · doi:10.1002/mus.880160810 · Cited by 121
Labelling of peripheral-type benzodiazepine binding sites in human brain with [3H]PK 11195: Anatomical and subcellular distribution
Doble, A., Malgouris, C., Daniel, M., Daniel, N., Imbault, F., Basbaum, A. I., Uzan, A., Gueremy, C., & Fur, G. L. (1987) · Brain Research Bulletin · doi:10.1016/0361-9230(87)90033-5 · Cited by 118
Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-α
Robertson, J., Beaulieu, J., Doroudchi, M. M., Durham, H. D., Julien, J., & Mushynski, W. E. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200107058 · Cited by 116
Visualization of mitotic radial glial lineage cells in the developing rat brain by Cdc2 kinase-phosphorylated vimentin
Kamei, Y., Inagaki, N., Nishizawa, M., Tsutsumi, O., Taketani, Y., & Inagaki, M. (1998) · Glia · doi:10.1002/(sici)1098-1136(199807)23:3 · Cited by 114
Fronto-temporal Dementia: Nosology, Neuropsychology, and Neuropathology
Neary, D., & Snowden, J. S. (1996) · Brain and Cognition · doi:10.1006/brcg.1996.0041 · Cited by 114
Motor Neuron Diseases: Comparison of Single-Voxel Proton MR Spectroscopy of the Motor Cortex with MR Imaging of the Brain
Chan, S., Shungu, D. C., Douglas‐Akinwande, A. C., Lange, D. J., & Rowland, L. P. (1999) · Radiology · doi:10.1148/radiology.212.3.r99au35763 · Cited by 107
Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis
Turner, M. R., Bakker, M., Sham, P. C., Shaw, C., Leigh, P. N., & Al‐Chalabi, A. (2002) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/146608202317576499 · Cited by 97
Self-citation
Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity
Klegeris, A., & MCGEER, P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00021-0 · Cited by 96
Cyclooxygenases in the Central Nervous System: Implications for Treatment of Neurological Disorders
Yermakova, A., & O’Banion, M. K. (2000) · Current Pharmaceutical Design · doi:10.2174/1381612003398672 · Cited by 94
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders
Dickson, D. W. (2011) · Wiley eBooks · doi:10.1002/9781444341256 · Cited by 92
Evidence for a dopaminergic deficit in sporadic amyotrophic lateral sclerosis on positron emission scanning
Takahashi, H., Snow, B. J., Bhatt, M. H., Peppard, R. F., Eisen, A., & Calne, D. B. (1993) · The Lancet · doi:10.1016/0140-6736(93)92878-w · Cited by 91
Brain plasticity and microglia: is transsynaptic glial activation in the thalamus after limb denervation linked to cortical plasticity and central sensitisation?
Banati, R. B. (2002) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(02)00018-9 · Cited by 84
Self-citation
Estimation of the Number of “True” Null Hypotheses in Multivariate Analysis of Neuroimaging Data
Turkheimer, F., Smith, C. B., & Schmidt, K. (2001) · NeuroImage · doi:10.1006/nimg.2001.0764 · Cited by 79
Self-citation
Mechanisms Underlying Neuronal Death Induced by Chromogranin A-activated Microglia
Ciesielski-Treska, J., Ulrich, G., Chasserot‐Golaz, S., Zwiller, J., Revel, M., Aunis, D., & Bader, M. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009711200 · Cited by 79
Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins
Schwab, C., Steele, J. C., & McGeer, P. L. (1996) · Brain Research · doi:10.1016/0006-8993(95)01257-5 · Cited by 62
Spatiotemporal progression of neurodegeneration and glia activation in the wobbler neuropathy of the mouse
Rathke‐Hartlieb, S., Schmidt, V. C., Jockusch, H., Schmitt‐John, T., & Bartsch, J. W. (1999) · Neuroreport · doi:10.1097/00001756-199911080-00028 · Cited by 55
Proton magnetic resonance spectroscopy and transcranial magnetic stimulation for the detection of upper motor neuron degeneration in ALS patients
Pohl, C., Block, W., Träber, F., Schmidt, S., Pels, H., Grothe, C., Schild, H. H., & Klockgether, T. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00568-8 · Cited by 49
Neuronophagia in the motor cortex in amyotrophic lateral sclerosis
Troost, D., Claessen, N., van den Oord, J. J., Swaab, D. F., & de Jong, J. M. B. V. (1993) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1993.tb00459.x · Cited by 44
Dementia with motor neurone disease.
Kew, J., & Leigh, N. (1992) · PubMed · Cited by 39
Neuro-inflammation as a therapeutic target in amyotrophic lateral sclerosis.
Weydt, P., Weiss, M. D., Möller, T., & Carter, G. T. (2002) · PubMed · Cited by 38
Transcranial magnetic stimulation compared with upper motor neuron signs in patients with amyotrophic lateral sclerosis
Schulte‐Mattler, W., Müller, T., & Zierz, S. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00201-4 · Cited by 37
Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG
Obál, I., Jakab, J. S. K., Siklós, L., & Engelhardt, J. I. (2001) · Neuroreport · doi:10.1097/00001756-200108080-00032 · Cited by 36
Nigrostriatal dopaminergic function in familial amyotrophic lateral sclerosis patients with and without copper/zinc superoxide dismutase mutations
Przedborski, S., DHAWAN, V. M., Donaldson, D. M., Murphy, P. L., McKenna‐Yasek, D., Mandel, F. S., Brown, R. H., & Eidelberg, D. (1996) · Neurology · doi:10.1212/wnl.47.6.1546 · Cited by 36
Autoradiography with [3H]PK11195 of spinal tract degeneration in amyotrophic lateral sclerosis
Sitte, H. H., Wanschitz, J., Budka, H., & Berger, M. L. (2001) · Acta Neuropathologica · doi:10.1007/s004010000312 · Cited by 31
Antibodies against microglia/brain macrophages in the cerebrospinal fluid of a patient with acute amyotrophic lateral sclerosis and presenile dementia.
Banati, R. B., Gehrmann, J., Kellner, M., & Holsboer, F. (1995) · PubMed · Cited by 26
Self-citation
Parametric Imaging of Ligand-Receptor Interactions Using a Reference Tissue Model and Cluster Analysis
Gunn, R. N., Lammertsma, A. A., & Cunningham, V. J. (1998) · Elsevier eBooks · doi:10.1016/b978-012161340-2/50062-7 · Cited by 26
Positron emission tomography (PET) – its potential to provide surrogate markers in ALS
Turner, M. R., & Leigh, P. N. (2000) · Amyotrophic Lateral Sclerosis · doi:10.1080/14660820052415781 · Cited by 24
Self-citation
Activation and response to axotomy of microglia in the facial motor nuclei of G93A superoxide dismutase transgenic mice
Mariotti, R., & Bentivoglio, M. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01034-x · Cited by 21
Amyotrophic Lateral Sclerosis
Urbánek, K. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490320074013 · Cited by 17
Positron emission tomography (PET) – its potential to provide surrogate markers in ALS
Turner, M. R., & Leigh, P. N. (2000) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/54-14660820050515665 · Cited by 14
Self-citation
Amyotrophic lateral sclerosis: A phylogenetic disease of the corticomotoneuron? Comments on the hypothesis
Swash, M. (1992) · Muscle & Nerve · doi:10.1002/mus.880150217 · Cited by 14
[Morphologic manifestations of the "inflammation" in sclerosis lateralis amyotrophica and their biologic significance].
Wiśniewska, K., & Tytulska, D. (1967) · PubMed · Cited by 1

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Authors: Turner, M. R., Cagnin, A., Turkheimer, F. E., Miller, C. C. J., Shaw, C. E., Brooks, D. J., Leigh, P. N., & Banati, R. B.
Affiliations: King's College London (GB)
University of Padua (IT)
Hammersmith Hospital (GB)
Corresponding author: Turner, M.R
ORCID: Turner, M.R
Turkheimer, F.E
Miller, C.C.J
Shaw, C.E
Brooks, D.J
Banati, R.B
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2004-04
Volume: 15
Issue: 3
Pages: 601-609
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2003.12.012
OpenAlex: W2019706623
Cited by: 737
References: 90
Citations by year: 2026: 15 · 2025: 23 · 2024: 37 · 2023: 31 · 2022: 40 · 2021: 52 · 2020: 52 · 2019: 43 · 2018: 43 · 2017: 44 · 2016: 42 · 2015: 42 · 2014: 47 · 2013: 42 · 2012: 27
FWCI: 15.87
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Research Portal (King's College London) (submittedVersion)
Padua Research Archive (University of Padova) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: amyotrophic lateral sclerosis, microglial activation, [11C]PK11195, positron emission tomography, translocator protein (TSPO), motor cortex, passive optical networks, dorsolateral prefrontal cortex, thalamus, upper motor neuron signs, neuroinflammation, neuropathology
MeSH terms: Adult, Amyotrophic Lateral Sclerosis, Brain, Female, Humans, Isoquinolines, Male, Middle Aged, Tomography, Emission-Computed, Microglia

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Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study

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