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Genetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesis
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“p53 loss alleviates changes in mHtt expression and mitochondrial dysfunction and prevents neuronal degeneration to relieve some of the neurobehavioral defects associated with HD.250”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [250]
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Cites
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
Arrasate, M., Mitra, S., Schweitzer, E. S., Segal, M. R., & Finkbeiner, S. (2004) · Nature · doi:10.1038/nature02998 · Cited by 1,979
p53 mutant mice that display early ageing-associated phenotypes
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · cited 1×
“…that has differing activities depending on p53 protein level, the inducing agent, and the cell type. p53 is also involved in lifespan regulation (Tyner et al., 2002; Maier et al., 2004), cell cycle control (Levine, 1997), DNA repair, and apoptosis (Vogelstein et al., 2000; Gomez-Lazaro et al.,…”
BackgroundEarly transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses
Sipione, S. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.17.1953 · Cited by 209
Research works printed but not linked: 38
- Albin, 1991, Preproenkephalin messenger RNA-containing neurons in striatum of patients with symptomatic and presymptomatic Huntington's disease: an in situ hybridization study, Ann. Neurol., 30, 542, 10.1002/ana.410300406 · DOI
- Amson, 2000, Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice, Proc. Natl. Acad. Sci. U. S. A., 97, 5346, 10.1073/pnas.97.10.5346 · DOI
- Bae, 2005, p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease, Neuron, 47, 29, 10.1016/j.neuron.2005.06.005 · DOI · Paper page
- Bodner, 2006, From the cover: pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases, Proc. Natl. Acad. Sci. U. S. A., 103, 4246, 10.1073/pnas.0511256103 · DOI · Paper page
- Cha, 2000, Transcriptional dysregulation in Huntington's disease, Trends Neurosci., 23, 387, 10.1016/S0166-2236(00)01609-X · DOI · Paper page
- Cronin, 2001, The lac operator-repressor system is functional in the mouse, Genes Dev., 15, 1506, 10.1101/gad.892001 · DOI
- DiFiglia, 1997, Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain, Science, 277, 1990, 10.1126/science.277.5334.1990 · DOI · Paper page
- Dragatsis, 2000, Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice, Nat. Genet., 26, 300, 10.1038/81593 · DOI · Paper page
- Duyao, 1995, Inactivation of the mouse Huntington's disease gene homolog Hdh, Science, 269, 407, 10.1126/science.7618107 · DOI · Paper page
- Feng, 2006, p53 tumor suppressor protein regulates the levels of huntingtin gene expression, Oncogene, 25, 1, 10.1038/sj.onc.1209021 · DOI
- Fusco, 1999, Cellular localization of huntingtin in striatal and cortical neurons in rats: lack of correlation with neuronal vulnerability in Huntington's disease, J. Neurosci., 19, 1189, 10.1523/JNEUROSCI.19-04-01189.1999 · DOI · Paper page
- Gomez-Lazaro, 2004, p53: twenty five years understanding the mechanism of genome protection, J. Physiol. Biochem., 60, 287, 10.1007/BF03167075 · DOI
- Hackam, 1999, In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease, Hum. Mol. Genet., 8, 25, 10.1093/hmg/8.1.25 · DOI
- Hickey, 2003, Apoptosis in Huntington's disease, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 27, 255, 10.1016/S0278-5846(03)00021-6 · DOI · Paper page
- Ho, 2001, The molecular biology of Huntington's disease, Psychol. Med., 31, 3, 10.1017/S0033291799002871 · DOI
- Kotliarova, 2005, Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine-EGFP fluorescent aggregates, J. Neurochem., 93, 641, 10.1111/j.1471-4159.2005.03035.x · DOI
- Levine, 1997, p53, the cellular gatekeeper for growth and division, Cell, 88, 323, 10.1016/S0092-8674(00)81871-1 · DOI · Paper page
- Li, 1999, Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin, J. Neurosci., 19, 5159, 10.1523/JNEUROSCI.19-13-05159.1999 · DOI
- Luthi-Carter, 2000, Decreased expression of striatal signaling genes in a mouse model of Huntington's disease, Hum. Mol. Genet., 9, 1259, 10.1093/hmg/9.9.1259 · DOI · Paper page
- Luthi-Carter, 2002, Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain, Hum. Mol. Genet., 11, 1911, 10.1093/hmg/11.17.1911 · DOI · Paper page
- Maier, 2004, Modulation of mammalian life span by the short isoform of p53, Genes Dev., 18, 306, 10.1101/gad.1162404 · DOI · Paper page
- Meade, 2002, Cellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic mice, J. Comp. Neurol., 449, 241, 10.1002/cne.10295 · DOI
- Menalled, 2005, Knock-in mouse models of Huntington's disease, NeuroRx, 2, 465, 10.1602/neurorx.2.3.465 · DOI
- Menalled, 2000, Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease, Exp. Neurol., 162, 328, 10.1006/exnr.1999.7327 · DOI
- Menalled, 2003, Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats, J. Comp. Neurol., 465, 11, 10.1002/cne.10776 · DOI · Paper page
- Nasir, 1995, Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes, Cell, 81, 811, 10.1016/0092-8674(95)90542-1 · DOI · Paper page
- Ryan, 2004, Visualization of the dynamics of gene expression in the living mouse, Mol. Imaging, 3, 33, 10.1162/153535004773861705 · doi:10.1162/153535004773861705
- Saudou, 1998, Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions, Cell, 95, 55, 10.1016/S0092-8674(00)81782-1 · DOI · Paper page
- Shahbazian, 2001, Reduction of Purkinje cell pathology in SCA1 transgenic mice by p53 deletion, Neurobiol. Dis., 8, 974, 10.1006/nbdi.2001.0444 · DOI
- Sharp, 1995, Widespread expression of Huntington's disease gene (IT15) protein product, Neuron, 14, 1065, 10.1016/0896-6273(95)90345-3 · DOI · Paper page
- Sieradzan, 2001, The selective vulnerability of nerve cells in Huntington's disease, Neuropathol. Appl. Neurobiol., 27, 1, 10.1046/j.0305-1846.2001.00299.x · DOI · Paper page
- Slow, 2005, Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions, Proc. Natl. Acad. Sci. U. S. A., 102, 11402, 10.1073/pnas.0503634102 · DOI · Paper page
- Vogelstein, 2000, Surfing the p53 network, Nature, 408, 307, 10.1038/35042675 · DOI · Paper page
- Young, 2002, A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy, J. Biol. Chem., 277, 2852, 10.1074/jbc.M108769200 · DOI
- Zeitlin, 1995, Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue, Nat. Genet., 11, 155, 10.1038/ng1095-155 · DOI · Paper page
- Zhang, 2003, Depletion of wild-type huntingtin in mouse models of neurologic diseases, J. Neurochem., 87, 101, 10.1046/j.1471-4159.2003.01980.x · DOI
- Zhao, 2004, PromoLign: a database for upstream region analysis and SNPs, Human Mutat., 23, 534, 10.1002/humu.20049 · DOI
- Zucker, 2005, Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1, Hum. Mol. Genet., 14, 179, 10.1093/hmg/ddi014 · DOI
Cited by
Mitochondria and Huntington's Disease Pathogenesis: Insight from Genetic and Chemical Models
Browne, S. E. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.018 · Cited by 176
Ghose, J., Sinha, M., Das, E., Jana, N. R., & Bhattacharyya, N. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023837 · Cited by 98
p53: from understanding its structure to advances in therapeutic targeting
Wang, W., Liu, X., Liu, H., Abolhassani, H., Yan, H., Zhang, H., & Wang, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02549-5 · Cited by 30
Metadata
- Authors
- Ryan, A. B., Zeitlin, S. O., & Scrable, H.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 24
- Issue
- 2
- Pages
- 419-427
- ISSN
- 0969-9961
- Cited by
- 33
- References
- 3
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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- Ryan, A. B., Zeitlin, S. O., & Scrable, H. (2006). Genetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesis. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2006.08.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.