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The blood-brain barrier and immune function and dysfunction
Open accessAbstract
The blood-brain barrier (BBB) is the monocellular interface that divides the peripheral circulation from direct contact with the central nervous system (CNS). This interface consists of several parallel barriers that include most notably the capillary bed of the CNS and the choroid plexus. These barriers at one level create the dichotomy between the circulating factors of the immune system and the components of the CNS only to regulate interactions between the immune and central nervous systems at other levels. The BBB is thus an integral part of the neuroimmune axis. Here, we will consider four aspects of BBB-neuroimmune interactions: BBB disruption as mediated by LPS and cytokines, cytokine transport across the BBB, immune cell trafficking, and effects of lipopolysaccharide (LPS) on various functions of the BBB.
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“Finally, although circulating LPS does not pass the blood–brain barrier to impact on neurons or glial cells per se [59], LPS modulates the blood–brain barrier function by its direct effect on the tight junction proteins and thus barrier permeability, as well as its interactions with the brain endothelial cells to regulate immune cell trafficking and cytokine transport as an indirect way for gut”
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Metadata
- Authors
- Banks, W. A., & Erickson, M. A.
- Affiliations
- Veterans Health Administration (US)
- St. Louis VA Medical Center (US)
- Corresponding author
- Banks, William A.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 37
- Issue
- 1
- Pages
- 26-32
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2031062821
- Cited by
- 523
- References
- 123
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 25 · 2023: 24 · 2022: 25 · 2021: 42 · 2020: 34 · 2019: 32 · 2018: 45 · 2017: 37 · 2016: 32 · 2015: 25 · 2014: 39 · 2013: 30 · 2012: 34
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (R01AG029839)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- blood-brain barrier, neuroimmune axis, blood-brain barrier disruption, lipopolysaccharide, cytokines, cytokine transport, immune cell trafficking, choroid plexus, central nervous system immunity
- MeSH terms
- Animals, Blood-Brain Barrier, Humans, Lipopolysaccharides, Models, Neurological, Neuroimmunomodulation, Cytokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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