The DOI matches its Crossref record; 119 of the 123 references it cites were found in a registry or an index.
The blood-brain barrier and immune function and dysfunction
Open accessAbstract
The blood-brain barrier (BBB) is the monocellular interface that divides the peripheral circulation from direct contact with the central nervous system (CNS). This interface consists of several parallel barriers that include most notably the capillary bed of the CNS and the choroid plexus. These barriers at one level create the dichotomy between the circulating factors of the immune system and the components of the CNS only to regulate interactions between the immune and central nervous systems at other levels. The BBB is thus an integral part of the neuroimmune axis. Here, we will consider four aspects of BBB-neuroimmune interactions: BBB disruption as mediated by LPS and cytokines, cytokine transport across the BBB, immune cell trafficking, and effects of lipopolysaccharide (LPS) on various functions of the BBB.
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“Finally, although circulating LPS does not pass the blood–brain barrier to impact on neurons or glial cells per se [59], LPS modulates the blood–brain barrier function by its direct effect on the tight junction proteins and thus barrier permeability, as well as its interactions with the brain endothelial cells to regulate immune cell trafficking and cytokine transport as an indirect way for gut”
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Cites
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
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FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE
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Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
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Multiplicity of cerebrospinal fluid functions: new challenges in health and disease
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Passage of cytokines across the blood–brain barrier
Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1996) · Neuroimmunomodulation · doi:10.1159/000097202 · Cited by 778
Self-citationChylomicrons promote intestinal absorption of lipopolysaccharides
Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662
Brain-immune communication pathways
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Self-citationPhysiology of the cerebro-spinal fluid
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Energy intake is associated with endotoxemia in apparently healthy men
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Psychobiotics and the manipulation of bacteria–gut–brain signals
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Metadata
- Authors
- Banks, W. A., & Erickson, M. A.
- Affiliations
- Veterans Health Administration (US)
- St. Louis VA Medical Center (US)
- Corresponding author
- Banks, William A.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 37
- Issue
- 1
- Pages
- 26-32
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2031062821
- Cited by
- 523
- References
- 123
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 25 · 2023: 24 · 2022: 25 · 2021: 42 · 2020: 34 · 2019: 32 · 2018: 45 · 2017: 37 · 2016: 32 · 2015: 25 · 2014: 39 · 2013: 30 · 2012: 34
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (R01AG029839)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- blood-brain barrier, neuroimmune axis, blood-brain barrier disruption, lipopolysaccharide, cytokines, cytokine transport, immune cell trafficking, choroid plexus, central nervous system immunity
- MeSH terms
- Animals, Blood-Brain Barrier, Humans, Lipopolysaccharides, Models, Neurological, Neuroimmunomodulation, Cytokines
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