Cited by 523Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsDrug Transport and Resistance Mechanisms

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The blood-brain barrier and immune function and dysfunction

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Banks, William A., Erickson, Michelle A.·2010·Neurobiology of Disease

DOI 10.1016/j.nbd.2009.07.031

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Abstract

The blood-brain barrier (BBB) is the monocellular interface that divides the peripheral circulation from direct contact with the central nervous system (CNS). This interface consists of several parallel barriers that include most notably the capillary bed of the CNS and the choroid plexus. These barriers at one level create the dichotomy between the circulating factors of the immune system and the components of the CNS only to regulate interactions between the immune and central nervous systems at other levels. The BBB is thus an integral part of the neuroimmune axis. Here, we will consider four aspects of BBB-neuroimmune interactions: BBB disruption as mediated by LPS and cytokines, cytokine transport across the BBB, immune cell trafficking, and effects of lipopolysaccharide (LPS) on various functions of the BBB.

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The interleukins-1α, -1β, and -2 do not acutely disrupt the murine blood - brain barrier
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Self-citation
Nitric oxide isoenzymes regulate lipopolysaccharide-enhanced insulin transport across the blood-brain barrier
Banks, W. A., Dohgu, S., Lynch, J. L., Fleegal-DeMotta, M. A., Erickson, M. A., Nakaoke, R., & Vo, T. Q. (2008) · Endocrinology · doi:10.1210/en.2007-1091 · Cited by 57
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Lymphocyte adhesion to brain capillary endothelial cells in vitro
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HIV-1-induced production of endothelin-1 in an in vitro model of the human blood???brain barrier
Didier, N., Banks, W. A., ́minon, C. C., Dereuddre‐Bosquet, N., & Mabondzo, A. M. (2002) · Neuroreport · doi:10.1097/00001756-200207020-00022 · Cited by 56
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Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis
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Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway
Dohgu, S., & Banks, W. A. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.12.028 · Cited by 46
Self-citation
Cytokine Transport Across the Injured Blood-Spinal Cord Barrier
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PSGL-1 is not required for development of experimental autoimmune encephalomyelitis
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Relative contributions of a CVO and the microvascular bed to delivery of blood-borne IL-1α to the brain
Maness, L. M., Kastin, A. J., & Banks, W. A. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e207 · Cited by 44
Self-citation
The effects of natalizumab on the innate and adaptive immune system in the central nervous system
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Central and Peripheral Mechanisms Contribute to the Hypoglycemia Induced by Interleukin‐1a
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Editorial [ Hot Topic: The Blood-Brain Barrier as a Cause of Disease (Executive Editor: William A. Banks) ]
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The role of inflammation in epilepsy
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Authors: Banks, W. A., & Erickson, M. A.
Affiliations: Veterans Health Administration (US)
St. Louis VA Medical Center (US)
Corresponding author: Banks, William A.
ORCID: Banks, William A.
Erickson, Michelle A.
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2010-01
Volume: 37
Issue: 1
Pages: 26-32
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2009.07.031
OpenAlex: W2031062821
Cited by: 523
References: 123
Citations by year: 2026: 19 · 2025: 32 · 2024: 25 · 2023: 24 · 2022: 25 · 2021: 42 · 2020: 34 · 2019: 32 · 2018: 45 · 2017: 37 · 2016: 32 · 2015: 25 · 2014: 39 · 2013: 30 · 2012: 34
FWCI: 2.10
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute on Aging (R01AG029839)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: blood-brain barrier, neuroimmune axis, blood-brain barrier disruption, lipopolysaccharide, cytokines, cytokine transport, immune cell trafficking, choroid plexus, central nervous system immunity
MeSH terms: Animals, Blood-Brain Barrier, Humans, Lipopolysaccharides, Models, Neurological, Neuroimmunomodulation, Cytokines

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The blood-brain barrier and immune function and dysfunction

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