Cited by 523Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsDrug Transport and Resistance Mechanisms

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The blood-brain barrier and immune function and dysfunction

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Banks, William A., Erickson, Michelle A.·2010·Neurobiology of Disease

DOI 10.1016/j.nbd.2009.07.031

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Abstract

The blood-brain barrier (BBB) is the monocellular interface that divides the peripheral circulation from direct contact with the central nervous system (CNS). This interface consists of several parallel barriers that include most notably the capillary bed of the CNS and the choroid plexus. These barriers at one level create the dichotomy between the circulating factors of the immune system and the components of the CNS only to regulate interactions between the immune and central nervous systems at other levels. The BBB is thus an integral part of the neuroimmune axis. Here, we will consider four aspects of BBB-neuroimmune interactions: BBB disruption as mediated by LPS and cytokines, cytokine transport across the BBB, immune cell trafficking, and effects of lipopolysaccharide (LPS) on various functions of the BBB.

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“In addition, gut-derived LPS can promote the disruption of the blood brain barrier (Banks et al., 2008; Banks and Erickson, 2010) and thus facilitate neuroinflammation and injury in the SN that is triggered by the above stated environmental factors.”
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Authors: Banks, W. A., & Erickson, M. A.
Affiliations: Veterans Health Administration (US)
St. Louis VA Medical Center (US)
Corresponding author: Banks, William A.
ORCID: Banks, William A.
Erickson, Michelle A.
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2010-01
Volume: 37
Issue: 1
Pages: 26-32
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2009.07.031
OpenAlex: W2031062821
Cited by: 523
References: 123
Citations by year: 2026: 19 · 2025: 32 · 2024: 25 · 2023: 24 · 2022: 25 · 2021: 42 · 2020: 34 · 2019: 32 · 2018: 45 · 2017: 37 · 2016: 32 · 2015: 25 · 2014: 39 · 2013: 30 · 2012: 34
FWCI: 2.10
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute on Aging (R01AG029839)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: blood-brain barrier, neuroimmune axis, blood-brain barrier disruption, lipopolysaccharide, cytokines, cytokine transport, immune cell trafficking, choroid plexus, central nervous system immunity
MeSH terms: Animals, Blood-Brain Barrier, Humans, Lipopolysaccharides, Models, Neurological, Neuroimmunomodulation, Cytokines

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The blood-brain barrier and immune function and dysfunction

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