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Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease
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The HD mutation reduces the production of active rab11, thereby slowing endosomal recycling of receptors and transporters to the cell surface.
“The HD mutation is known to reduce the production of active rab11, thereby slowing endosomal recycling of receptors and transporters to the cell surface [23-26].”
From Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice (2014) · cites this paper as [23]
Diminished rab11 activity in HD cells affects the recycling of transferrin receptor and neuronal glutamate/cysteine transporter EAAC1.
“Rab11 regulates numerous receptors and transporters trafficking onto cell surfaces; its diminished activity in HD cells affects the recycling of transferrin receptor and neuronal glutamate/cysteine transporter EAAC1.”
From Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice (2014) · cites this paper as [23]
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Cites
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Recycling Endosomes Supply AMPA Receptors for LTP
Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., & Ehlers, M. D. (2004) · Science · doi:10.1126/science.1102026 · Cited by 730
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse
Aoyama, K., Suh, S. W., Hamby, A. M., Liu, J., Chan, W. Y., Chen, Y., & Swanson, R. A. (2006) · Nature Neuroscience · doi:10.1038/nn1609 · Cited by 484
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Cited by
Sorted by citations
Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease
Richards, P., Didszun, C., Campesan, S., Simpson, A., Horley, B., Young, K. W., Glynn, P., Cain, K., Kyriacou, C. P., Giorgini, F., et al. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.127 · Cited by 82
McClory, H., Williams, D., Sapp, E., Gatune, L. W., Wang, P., DiFiglia, M., & Li, X. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0178-7 · Cited by 60
Self-citationAxonopathy in Huntington's disease
Li, J.-Y., & Conforti, L. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2012.08.010 · Cited by 55
Metadata
- Authors
- Li, X., Sapp, E., Chase, K., Comer-Tierney, L. A., Masso, N., Alexander, J., Reeves, P., Kegel, K. B., Valencia, A., Esteves, M., Aronin, N., & DiFiglia, M.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 36
- Issue
- 2
- Pages
- 374-383
- ISSN
- 0969-9961
- PMC
- PMC2798579
- Cited by
- 87
- References
- 3
- Language
- en
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