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Rab11 Regulates the Compartmentalization of Early Endosomes Required for Efficient Transport from Early Endosomes to the Trans-Golgi Network

Wilcke, Mona, Johannes, Ludger, Galli, Thierry, Mayau, Véronique, Goud, Bruno, Salamero, Jean·2000·The Journal of Cell Biology
DOI 10.1083/jcb.151.6.1207PMC PMC2190589
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Abstract

Several GTPases of the Rab family, known to be regulators of membrane traffic between organelles, have been described and localized to various intracellular compartments. Rab11 has previously been reported to be associated with the pericentriolar recycling compartment, post-Golgi vesicles, and the trans-Golgi network (TGN). We compared the effect of overexpression of wild-type and mutant forms of Rab11 on the different intracellular transport steps in the endocytic/degradative and the biosynthetic/exocytic pathways in HeLa cells. We also studied transport from endosomes to the Golgi apparatus using the Shiga toxin B subunit (STxB) and TGN38 as reporter molecules. Overexpression of both Rab11 wild-type (Rab11wt) and mutants altered the localization of the transferrrin receptor (TfR), internalized Tf, the STxB, and TGN38. In cells overexpressing Rab11wt and in a GTPase-deficient Rab11 mutant (Rab11Q70L), these proteins were found in vesicles showing characteristics of sorting endosomes lacking cellubrevin (Cb). In contrast, they were redistributed into an extended tubular network, together with Cb, in cells overexpressing a dominant negative mutant of Rab11 (Rab11S25N). This tubularized compartment was not accessible to Tf internalized at temperatures <20°C, suggesting that it is of recycling endosomal origin. Overexpression of Rab11wt, Rab11Q70L, and Rab11S25N also inhibited STxB and TGN38 transport from endosomes to the TGN. These results suggest that Rab11 influences endosome to TGN trafficking primarily by regulating membrane distribution inside the early endosomal pathway.

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Metadata

Authors
Wilcke, M., Johannes, L., Galli, T., Mayau, V., Goud, B., & Salamero, J.
Affiliations
  • aUMR CNRS 144, Laboratoire Mécanismes Moléculaires du Transport Intracellulaire, Institut Curie, F-75248 Paris Cedex 05, France
  • bUnité de Génétique Somatique, URA CNRS 1960, Institut Pasteur, 75724 Paris Cedex 15, France
Venue
The Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2000-12-11
Volume
151
Issue
6
Pages
1207-1220
ISSN
  • 0021-9525
  • 1540-8140
DOI
10.1083/jcb.151.6.1207
PMC
PMC2190589
Cited by
360
References
0
Language
en

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