The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling
Open accessAbstract
Pathological gambling (PG) represents a behavioral side effect of dopamine replacement therapy in a minority of patients with Parkinson's disease (PD). Using striatal dopamine transporter (DAT) with single photon emission tomography we assessed presynaptic dopaminergic function in 8 PD patients with PG, 21 matched PD control subjects, and 14 healthy subjects. Statistical Parametric Mapping was applied for image analysis. The analysis of variance (ANOVA) revealed that the three groups differed in dorsal and ventral striata bilaterally. The post-hoc analysis displayed a reduced tracer binding in the ventral striatum of PD patients with PG compared to PD controls, possibly reflecting either a reduction of mesolimbic projections or, alternatively, a lower membrane DAT expression on presynaptic terminals. The latter hypothesis is most likely given that the functional reduction of presynaptic reuptake would be more consistent with the increased dopamine levels in the ventral striatum recently reported in PD gamblers.
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Cites
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Self-citationCompulsive drug use linked to sensitized ventral striatal dopamine transmission.
Evans, A. H., Pavese, N., Lawrence, A. D., Tai, Y. F., Appel, S., Doder, M., Brooks, D. J., Lees, A. J., & Piccini, P. (2006) · Annals of Neurology · doi:10.1002/ana.20822 · Cited by 473
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Cited by
Leeman, R. F., & Potenza, M. N. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2550-7 · Cited by 448
Survival and dementia in GBA ‐associated Parkinson's disease: The mutation matters
Cilia, R., Tunesi, S., Marotta, G., Cereda, E., Siri, C., Tesei, S., Zecchinelli, A. L., Canesi, M., Mariani, C. B., Meucci, N., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24777 · Cited by 406
Self-citationImpulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update
Voon, V., Napier, T. C., Frank, M. J., Sgambato-Faure, V., Grace, A. A., Rodriguez-Oroz, M., Obeso, J., Bezard, E., & Fernagut, P.-O. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30004-2 · Cited by 359
Dopamine modulates novelty seeking behavior during decision making.
Costa, V. D., Tran, V. L., Turchi, J., & Averbeck, B. B. (2014) · Behavioral Neuroscience · doi:10.1037/a0037128 · Cited by 263
Clark, L., Stokes, P. R., Wu, K., Michalczuk, R., Benecke, A., Watson, B. J., Egerton, A., Piccini, P., Nutt, D. J., Bowden-Jones, H., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.067 · Cited by 193
Metadata
- Authors
- Cilia, R., Ko, J. H., Cho, S. S., van Eimeren, T., Marotta, G., Pellecchia, G., Pezzoli, G., Antonini, A., & Strafella, A. P.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 39
- Issue
- 1
- Pages
- 98-104
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2080914089
- Cited by
- 159
- References
- 6
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Cilia, R., Ko, J. H., Cho, S. S., van Eimeren, T., Marotta, G., Pellecchia, G., Pezzoli, G., Antonini, A., & Strafella, A. P. (2010). Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2010.03.013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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