Striatal dopamine D2/D3 receptor binding in pathological gambling is correlated with mood-related impulsivity
Open accessAbstract
Pathological gambling (PG) is a behavioural addiction associated with elevated impulsivity and suspected dopamine dysregulation. Reduced striatal dopamine D(2)/D(3) receptor availability has been reported in drug addiction, and may constitute a premorbid vulnerability marker for addictive disorders. The aim of the present study was to assess striatal dopamine D(2)/D(3) receptor availability in PG, and its association with trait impulsivity. Males with PG (n=9) and male healthy controls (n=9) underwent [11C]-raclopride positron emission tomography imaging and completed the UPPS-P impulsivity scale. There was no significant difference between groups in striatal dopamine D(2)/D(3) receptor availability, in contrast to previous reports in drug addiction. However, mood-related impulsivity ('Urgency') was negatively correlated with [11C]-raclopride binding potentials in the PG group. The absence of a group difference in striatal dopamine binding implies a distinction between behavioural addictions and drug addictions. Nevertheless, our data indicate heterogeneity in dopamine receptor availability in disordered gambling, such that individuals with high mood-related impulsivity may show differential benefits from dopamine-based medications.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Decreases in D2 receptor binding are not seen in pathological gamblers compared with controls, despite a significant impulsive component.
“However, it should be noted that decreases in D2 receptor binding are not seen in pathological gamblers compared to control subjects, which also has a significant impulsive component (Boileau et al., 2013; Clark et al., 2012; Joutsa et al., 2012; Linnet et al., 2011).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Clark et al., 2012
In two studies of pathological gamblers, low D2 binding correlated with greater impulsivity within the group.
“Nonetheless, two of these studies (Boileau et al., 2013; Clark et al., 2012) did show that low D2 binding correlated with greater impulsivity within the group of gamblers.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Clark et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
(1998) · PubMed · Cited by 10,216 · see citing works
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
(1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.9.1184 · Cited by 2,948 · see citing works
A pathways model of problem and pathological gambling
Blaszczynski, A., & Nower, L. (2002) · Addiction · doi:10.1046/j.1360-0443.2002.00015.x · Cited by 2,013 · see citing works
Consensus Nomenclature for <i>in vivo</i> Imaging of Reversibly Binding Radioligands
Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Houle, S., Huang, S.-C., Ichise, M., et al. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600493 · Cited by 1,955 · see citing works
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864 · see citing works
Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
Cools, R., & D'Esposito, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.028 · Cited by 1,673 · see citing works
Verdejo‐García, A., Lawrence, A. J., & Clark, L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.11.003 · Cited by 1,414 · see citing works
Self-citationCyders, M. A., Smith, G. T., Spillane, N. S., Fischer, S., Annus, A. M., & Peterson, C. (2007) · Psychological Assessment · doi:10.1037/1040-3590.19.1.107 · Cited by 1,193 · see citing works
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S. J., Theobald, D. E. H., Lääne, K., Peña, Y., Murphy, E. R., Shah, Y., Probst, K., et al. (2007) · Science · doi:10.1126/science.1137073 · Cited by 1,188 · see citing works
Emotion-based dispositions to rash action: positive and negative urgency
Cyders, M. A., & Smith, G. T. (2008) · Psychological Bulletin · doi:10.1037/a0013341 · Cited by 1,136 · see citing works
DSM-IV pathological gambling in the National Comorbidity Survey Replication
Kessler, R. C., Hwang, I., LaBrie, R., Petukhova, M., Sampson, N. A., Winters, K. C., & Shaffer, H. J. (2008) · Psychological Medicine · doi:10.1017/s0033291708002900 · Cited by 928 · cited 1× · see citing works
“Psychiatric comorbidities are of course highly prevalent in PG (Kessler et al., 2008) and the inclusion of such cases does enhance the generalizability of our findings.”
Volkow, N. D., Chang, L., Wang, G.-J., Fowler, J. S., Ding, Y.-S., Sedler, M., Logan, J., Franceschi, D., Gatley, J., Hitzemann, R., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2015 · Cited by 916 · see citing works
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997) · Nature · doi:10.1038/386830a0 · Cited by 854 · see citing works
Pathological gambling is linked to reduced activation of the mesolimbic reward system
Reuter, J., Raedler, T., Rose, M., Hand, I., Gläscher, J., & Büchel, C. (2005) · Nature Neuroscience · doi:10.1038/nn1378 · Cited by 734 · see citing works
Dopaminergic Network Differences in Human Impulsivity
Buckholtz, J. W., Treadway, M. T., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Shelby, E. S., Smith, C. E., et al. (2010) · Science · doi:10.1126/science.1185778 · Cited by 600 · see citing works
Martinez, D., Slifstein, M., Broft, A., Mawlawi, O., Hwang, D.-R., Huang, Y., Cooper, T., Kegeles, L., Zarahn, E., Abi-Dargham, A., et al. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048520.34839.1a · Cited by 569 · see citing works
Steeves, T. D. L., Miyasaki, J., Zurowski, M., Lang, A. E., Pellecchia, G., Van Eimeren, T., Rusjan, P., Houle, S., & Strafella, A. P. (2009) · Brain · doi:10.1093/brain/awp054 · Cited by 502 · see citing works
Canadian Problem Gambling Index
Ferris, J., Wynne, H., & Single, E. (2011) · PsycTESTS Dataset · doi:10.1037/t00772-000 · Cited by 499 · see citing works
PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
Nader, M. A., Morgan, D., Gage, H. D., Nader, S. H., Calhoun, T. L., Buchheimer, N., Ehrenkaufer, R., & Mach, R. H. (2006) · Nature Neuroscience · doi:10.1038/nn1737 · Cited by 481 · see citing works
Age-Related Cognitive Deficits Mediated by Changes in the Striatal Dopamine System
Bäckman, L., Ginovart, N., Dixon, R. A., Wahlin, T. R., Wåhlin, Å., Halldin, C., & Farde, L. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.4.635 · Cited by 473 · see citing works
Leeman, R. F., & Potenza, M. N. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2550-7 · Cited by 448 · see citing works
Drug Addiction Endophenotypes: Impulsive Versus Sensation-Seeking Personality Traits
Ersche, K. D., Turton, A. J., Pradhan, S., Bullmore, E. T., & Robbins, T. W. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.015 · Cited by 422 · see citing works
Heinz, A., Siessmeier, T., Wrase, J., Hermann, D., Klein, S., Grüsser-Sinopoli, S. M., Flor, H., Braus, D. F., Buchholz, H. G., Gründer, G., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1783 · Cited by 408 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Gifford, A., Hitzemann, R., Ding, Y.-S., & Pappas, N. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1440 · Cited by 406 · see citing works
Lee, B., London, E. D., Poldrack, R. A., Farahi, J., Nacca, A., Monterosso, J. R., Mumford, J. A., Bokarius, A. V., Dahlbom, M., Mukherjee, J., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3765-09.2009 · Cited by 374 · see citing works
Voon, V., Fernagut, P., Wickens, J. R., Baunez, C., Rodríguez‐Oroz, M., Pavon, N., Juncos, J. L., Obeso, J. A., & Bézard, E. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70287-x · Cited by 352 · see citing works
Development and psychometric evaluation of a three‐dimensional Gambling Motives Questionnaire
Stewart, S. H., & Zack, M. H. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02235.x · Cited by 344 · see citing works
Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Frankel, W. G., Cooper, T., Kleber, H. D., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300420 · Cited by 306 · see citing works
O'Sullivan, S. S., Wu, K., Politis, M., Lawrence, A. D., Evans, A. H., Bose, S. K., Djamshidian, A., Lees, A. J., & Piccini, P. (2011) · Brain · doi:10.1093/brain/awr003 · Cited by 297 · see citing works
Self-citationMichalczuk, R., Bowden-Jones, H., Verdejo-Garcia, A., & Clark, L. (2011) · Psychological Medicine · doi:10.1017/s003329171100095x · Cited by 248 · see citing works
Self-citationPathological gambling among adolescents: Massachusetts Gambling Screen (MAGS)
Shaffer, H. J., LaBrie, R. A., Scanlan, K. M., & Cummings, T. N. (1994) · Journal of Gambling Studies · doi:10.1007/bf02104901 · Cited by 239 · see citing works
Dopamine Transmission in the Human Striatum during Monetary Reward Tasks
Zald, D. H., Boileau, I., El-Dearedy, W., Gunn, R., McGlone, F., Dichter, G. S., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4643-03.2004 · Cited by 238 · see citing works
Quantification of Amphetamine-Induced Changes in [ 11 C]Raclopride Binding with Continuous Infusion
Carson, R. E., Breier, A. F., de Bartolomeis, A., Saunders, R. C., Su, T., Schmall, B., Der, M. G., Pickar, D., & Eckelman, W. C. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199704000-00009 · Cited by 237 · see citing works
Personality and Problem Gambling
Slutske, W. S., Caspi, A., Moffitt, T. E., & Poulton, R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.7.769 · Cited by 235 · see citing works
Fehr, C., Yakushev, I. Y., Hohmann, N., Buchholz, H., Landvogt, C., Deckers, H., Eberhardt, A., Kläger, M., Smolka, M. N., Scheurich, A., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07020352 · Cited by 226 · see citing works
Linnet, J., Møller, A., Peterson, E., Gjedde, A., & Doudet, D. (2011) · Addiction · doi:10.1111/j.1360-0443.2010.03126.x · Cited by 214 · see citing works
Altered dopamine function in pathological gambling
Bergh, C. E. K., Eklund, T., Södersten, P., & Nordin, C. (1997) · Psychological Medicine · doi:10.1017/s0033291796003789 · Cited by 212 · see citing works
Mesolimbic dopamine release is linked to symptom severity in pathological gambling
Joutsa, J., Johansson, J., Niemelä, S., Ollikainen, A., Hirvonen, M. M., Piepponen, P., Arponen, E., Alho, H., Voon, V., Rinne, J. O., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.006 · Cited by 209 · see citing works
Neuroendocrine response to casino gambling in problem gamblers
Meyer, G., Schwertfeger, J., Exton, M. S., Janssen, O. E., Knapp, W., Stadler, M. A., Schedlowski, M., & Krüger, T. H. C. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.03.005 · Cited by 198 · see citing works
Frascella, J., Potenza, M. N., Brown, L. L., & Childress, A. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05420.x · Cited by 191 · see citing works
The dopaminergic basis of human behaviors: a review of molecular imaging studies
Egerton, A., Mehta, M., Montgomery, A., Lappin, J., Howes, O., Reeves, S., Cunningham, V., & Grasby, P. (2009) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.05.005 · Cited by 180 · see citing works
Self-citationGambling Severity Predicts Midbrain Response to Near-Miss Outcomes
Chase, H. W., & Clark, L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5758-09.2010 · Cited by 168 · see citing works
Self-citationMartínez, D., Greene, K. A., Broft, A. I., Kumar, D. J. S., Liu, F., Narendran, R., Slifstein, M., Heertum, R. V., & Kleber, H. D. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121801 · Cited by 166 · see citing works
FONG, T. W., Kalechstein, A. D., Bernhard, B. J., Rosenthal, R. J., & Rugle, L. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.12.025 · Cited by 160 · see citing works
Ito, H., Hietala, J. A., Blomqvist, G., Halldin, C., & Farde, L. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199809000-00003 · Cited by 158 · see citing works
Cilia, R., Ko, J. H., Cho, S. S., van Eimeren, T., Marotta, G., Pellecchia, G., Pezzoli, G., Antonini, A., & Strafella, A. P. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.03.013 · Cited by 158 · see citing works
Olanzapine in the Treatment of Pathological Gambling
McElroy, S. L., Nelson, E. B., Welge, J. A., Kaehler, L. A., & Keck, P. E. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0314 · Cited by 157 · see citing works
Correction of head movement on PET studies: comparison of methods.
Montgomery, A. J., Thielemans, K., Mehta, M. A., Turkheimer, F., Mustafovic, S., & Grasby, P. M. (2006) · PubMed · Cited by 139 · see citing works
Boy, F., Evans, J., Edden, R. A. E., Lawrence, A. D., Singh, K. D., Husain, M., & Sumner, P. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.030 · Cited by 132 · see citing works
Gjedde, A., Kumakura, Y., Cumming, P., Linnet, J., & Møller, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912319107 · Cited by 130 · see citing works
Watabe, H., Endres, C. J., Breier, A. F., Schmall, B., Eckelman, W. C., & Carson, R. E. (2000) · PubMed · Cited by 102 · see citing works
Correction of head movement in PET studies: a comparison of methods
Montgomery, A. J., Mehta, M. A., Turkheimer, F., Thielemans, K., Mustafovic, S., & Grasby, P. M. (2004) · Research Portal (King's College London) · Cited by 101 · see citing works
Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge
Stokes, P. R. A., Egerton, A., Watson, B., Reid, A., Breen, G., Lingford-Hughes, A., Nutt, D., & Mehta, M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.274 · Cited by 75 · see citing works
Self-citationDopaminergic activity in depressed smokers: A positron emission tomography study
Busto, U. E., Redden, L., Mayberg, H. S., Kapur, S., Houle, S., & Zawertailo, L. A. (2009) · Synapse · doi:10.1002/syn.20646 · Cited by 54 · see citing works
Pathological gambling and the treatment of psychosis with aripiprazole: case reports
Smith, N. T., Kitchenham, N., & Bowden‐Jones, H. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.084996 · Cited by 43 · see citing works
Self-citationEgerton, A., Shotbolt, J. P., Stokes, P. R. A., Hirani, E., Ahmad, R., Lappin, J., Reeves, S., Mehta, M. A., Howes, O. D., & Grasby, P. M. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.077 · Cited by 31 · see citing works
Self-citationPathological gambling: a neurobiological and clinical update
Bowden‐Jones, H., & Clark, L. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.088146 · Cited by 31 · see citing works
Self-citationMatsumoto, M., Togashi, H., Kaku, A., Kanno, M., Tahara, K., & Yoshioka, M. (2005) · Synapse · doi:10.1002/syn.20131 · Cited by 26 · see citing works
Kim, J., Son, Y., Kim, H.-K., Lee, S., Cho, S., Kim, Y.-B., & Cho, Z. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.03.009 · Cited by 24 · see citing works
Flagged first, then by citations
4 of the 65 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The dopamine theory of addiction: 40 years of highs and lows
Nutt, D., Lingford-Hughes, A. R., Erritzøe, D., & Stokes, P. R. A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3939 · Cited by 647 · see citing works
Self-citationPotenza, M. N., Balodis, I. M., Derevensky, J., Grant, J. E., Petry, N. M., Verdejo-Garcia, A., & Yip, S. W. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0099-7 · Cited by 437 · see citing works
Validation of a short French version of the UPPS-P Impulsive Behavior Scale
Billieux, J., Rochat, L., Ceschi, G., Carré, A., Offerlin-Meyer, I., Defeldre, A.-C., Khazaal, Y., Besche‐Richard, C., & der Linden, M. V. (2011) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2011.09.001 · Cited by 428 · see citing works
Wise, R. A., & Robble, M. A. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-103337 · Cited by 418 · see citing works
Integrating affect and impulsivity: The role of positive and negative urgency in substance use risk
Smith, G. T., & Cyders, M. A. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.08.038 · Cited by 323 · see citing works
Gambling Disorder and Other Behavioral Addictions: Recognition and Treatment
Yau, Y. H. C., & Potenza, M. N. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000051 · Cited by 267 · see citing works
Boileau, I., Payer, D., Chugani, B., Lobo, D. S. S., Houle, S., Wilson, A. A., Warsh, J., Kish, S. J., & Zack, M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.163 · Cited by 198 · see citing works
Boileau, I., Payer, D., Chugani, B., Lobo, D., Behzadi, A., Rusjan, P. M., Houle, S., Wilson, A. A., Warsh, J., Kish, S. J., et al. (2013) · Addiction · doi:10.1111/add.12066 · Cited by 190 · see citing works
Validation of a short Spanish version of the UPPS-P impulsive behaviour scale
Cándido, A., Orduña, E., Perales, J. C., Verdejo-García, A., & Billieux, J. (2012) · Trastornos Adictivos · doi:10.1016/s1575-0973(12)70048-x · Cited by 176 · see citing works
Neurobiology of gambling behaviors
Potenza, M. N. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.03.004 · Cited by 179 · see citing works
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
Neurobiology of cue-reactivity, craving, and inhibitory control in non-substance addictive behaviors
Antons, S., Brand, M., & Potenza, M. N. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116952 · Cited by 165 · see citing works
Impulsivity: Four Ways Five Factors are Not Basic to Addiction
Gullo, M. J., Loxton, N. J., & Dawe, S. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.01.002 · Cited by 167 · see citing works
Neuroimaging of reward mechanisms in Gambling disorder: an integrative review
Clark, L., Boileau, I., & Zack, M. H. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0230-2 · Cited by 149 · see citing works
Self-citationDisordered gambling: the evolving concept of behavioral addiction
Clark, L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12558 · Cited by 150 · see citing works
Self-citationStriatal D1 and D2 signaling differentially predict learning from positive and negative outcomes
Cox, S. M. L., Frank, M. J., Larcher, K. M.-H., Fellows, L. K., Clark, C. A., Leyton, M., & Dagher, A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2014.12.070 · Cited by 144 · see citing works
Sensation-seeking: dopaminergic modulation and risk for psychopathology
Norbury, A., & Husain, M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.015 · Cited by 142 · see citing works
Majuri, J., Joutsa, J., Johansson, J. J., Voon, V., Alakurtti, K., Parkkola, R. K., Lahti, T. A., Alho, H., Hirvonen, J., Arponen, E., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.265 · Cited by 140 · see citing works
Reward, interrupted: Inhibitory control and its relevance to addictions
Jentsch, J. D., & Pennington, Z. T. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.022 · Cited by 134 · see citing works
Risk-taking and decision-making in youth: Relationships to addiction vulnerability
Balogh, K. N., Mayes, L. C., & Potenza, M. N. (2013) · Journal of Behavioral Addictions · doi:10.1556/jba.2.2013.1.1 · Cited by 123 · see citing works
Pathological choice: the neuroscience of gambling and gambling addiction
Clark, L., Averbeck, B., Payer, D., Sescousse, G., Winstanley, C. A., & Xue, G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3231-13.2013 · Cited by 116 · see citing works
Self-citationBrain structure correlates of emotion-based rash impulsivity
Muhlert, N., & Lawrence, A. D. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.04.061 · Cited by 113 · see citing works
Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers
Mick, I., Myers, J., Ramos, A. C., Stokes, P. R. A., Erritzoe, D., Colasanti, A., Gunn, R. N., Rabiner, E. A., Searle, G. E., Waldman, A. D., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.340 · Cited by 112 · see citing works
Self-citationIncreased Striatal Dopamine Synthesis Capacity in Gambling Addiction
van Holst, R. J., Sescousse, G., Janssen, L. K., Janssen, M., Berry, A. S., Jagust, W. J., & Cools, R. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.010 · Cited by 111 · see citing works
Behavioural addiction—A rising tide?
Chamberlain, S. R., Löchner, C., Stein, D. J., Goudriaan, A. E., van Holst, R. J., Zohar, J., & Grant, J. E. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.08.013 · Cited by 113 · see citing works
Disordered gambling: a behavioral addiction
Clark, L., & Limbrick‐Oldfield, E. H. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.004 · Cited by 108 · see citing works
Self-citationReward-based decision making in pathological gambling: The roles of risk and delay
Wiehler, A., & Peters, J. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.09.008 · Cited by 106 · see citing works
The neural bases of cognitive processes in gambling disorder
Potenza, M. N. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2014.03.007 · Cited by 104 · see citing works
How central is dopamine to pathological gambling or gambling disorder?
Potenza, M. N. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00206 · Cited by 103 · see citing works
Psychedelic therapy in the treatment of addiction: the past, present and future
Zafar, R. R., Siegel, M., Harding, R., Barba, T., Agnorelli, C., Suseelan, S., Roseman, L., Wall, M. B., Nutt, D., & Erritzøe, D. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1183740 · Cited by 108 · see citing works
Self-citationImpulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency
Zorrilla, E. P., & Koob, G. F. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00136 · Cited by 96 · see citing works
Johnson, S. L., Elliott, M. V., & Carver, C. S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.08.018 · Cited by 90 · see citing works
Getting a grip on problem gambling: what can neuroscience tell us?
Goudriaan, A., Yücel, M., & van Holst, R. V. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00141 · Cited by 92 · see citing works
Neural and psychological underpinnings of gambling disorder: A review
Grant, J. E., Odlaug, B. L., & Chamberlain, S. R. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.10.007 · Cited by 88 · see citing works
Dopaminergic function and intertemporal choice
Joutsa, J., Voon, V., Johansson, J. J., Niemelä, S., Bergman, J. R., & Kaasinen, V. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.133 · Cited by 81 · see citing works
Conceptual Framework of Harmful Gambling, Third Edition
Abbott, M., Binde, P., Clark, L., Hodgins, D., Johnson, M., Manitowabi, D., Quilty, L., Spångberg, J., Volberg, R., Walker, D. M., et al. (2018) · doi:10.33684/cfhg3.en · Cited by 22 · see citing works
Self-citationBehavioral endophenotypes of drug addiction: Etiological insights from neuroimaging studies
Jupp, B., & Dalley, J. W. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.041 · Cited by 77 · see citing works
The Functional Anatomy of Impulse Control Disorders
Probst, C. C., & van Eimeren, T. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0386-8 · Cited by 77 · see citing works
Neuroimaging and Biomarkers in Addiction Treatment
Garrison, K. A., & Potenza, M. N. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0513-5 · Cited by 73 · see citing works
Right on Cue? Striatal Reactivity in Problem Gamblers
van Holst, R. J., Veltman, D. J., van den Brink, W., & Goudriaan, A. E. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.017 · Cited by 68 · see citing works
Impulsivity traits and gambling cognitions associated with gambling preferences and clinical status
Navas, J. F., Billieux, J., Perandrés‐Gómez, A., López-Torrecillas, F., Cândido, A., & Perales, J. C. (2017) · International Gambling Studies · doi:10.1080/14459795.2016.1275739 · Cited by 69 · see citing works
The Cambridge Handbook of Substance and Behavioral Addictions
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591 · Cited by 63 · see citing works
Amplified Striatal Responses to Near-Miss Outcomes in Pathological Gamblers
Sescousse, G., Janssen, L. K., Hashemi, M. M., Timmer, M. H. M., Geurts, D. E. M., ter Huurne, N. P., Clark, L., & Cools, R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.43 · Cited by 62 · see citing works
Self-citationMartini, A., Lago, D. D., Edelstyn, N. M. J., Grange, J. A., & Tamburin, S. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00654 · Cited by 61 · see citing works
Yang, B., Balodis, I. M., Lacadie, C., Xu, J., & Potenza, M. N. (2016) · Journal of Behavioral Addictions · doi:10.1556/2006.5.2016.026 · Cited by 59 · see citing works
Browne, M., Delfabbro, P., Thorne, H. B., Tulloch, C., Rockloff, M., Hing, N., Dowling, N. A., & Stevens, M. (2023) · Journal of Behavioral Addictions · doi:10.1556/2006.2022.00083 · Cited by 58 · see citing works
Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status
Eisenstein, S. A., Bogdan, R., Love-Gregory, L. D., Corral-Frías, N. S., Koller, J. M., BLACK, K. J., Moerlein, S. M., Perlmutter, J. S., Barch, D. M., & Hershey, T. G. (2016) · Synapse · doi:10.1002/syn.21916 · Cited by 54 · see citing works
Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency
Um, M., Whitt, Z. T., Revilla, R., Hunton, T., & Cyders, M. A. (2019) · Brain Sciences · doi:10.3390/brainsci9020036 · Cited by 53 · see citing works
Neurobiological underpinnings of reward anticipation and outcome evaluation in gambling disorder
Linnet, J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00100 · Cited by 55 · see citing works
Reed, D. D., Naudé, G. P., Gelino, B. W., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.011 · Cited by 48 · see citing works
Murch, W. S., & Clark, L. (2015) · The Neuroscientist · doi:10.1177/1073858415591474 · Cited by 49 · see citing works
Self-citationExcessive Internet Use and Personality Traits
Floros, G. D., & Siomos, K. E. (2014) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-014-0006-1 · Cited by 50 · see citing works
Translational Models of Gambling-Related Decision-Making
Winstanley, C. A., & Clark, L. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5014 · Cited by 47 · see citing works
Self-citationOswald, L. M., Wand, G. S., Wong, D. F., Brown, C. H., Kuwabara, H., & Brašić, J. R. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.03.022 · Cited by 45 · see citing works
The Prevention and Treatment of Gambling Disorders: Some Art, Some Science
Derevensky, J. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.024 · Cited by 45 · see citing works
Behavioral addictions in addiction medicine
Banz, B. C., Yip, S. W., Yau, Y. H. C., & Potenza, M. N. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.08.003 · Cited by 46 · see citing works
Considering the Overlap and Nonoverlap of Compulsivity, Impulsivity, and Addiction
Blum, A. W., & Grant, J. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.038 · Cited by 44 · see citing works
Neurobiological Foundations of Behavioral Addictions
Vaccaro, A. G., & Potenza, M. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.016 · Cited by 45 · see citing works
Neurobiology of Substance Addictions
Christie, N. C., & Bechara, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.015 · Cited by 44 · see citing works
Sensitization of Incentive Salience and the Transition to Addiction
Warlow, S. M., Baumgartner, H. M., Freeland, C. M., Naffziger, E. E., Olney, J. J., Berridge, K. C., & Robinson, M. J. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.006 · Cited by 45 · see citing works
Hillemacher, T., Frieling, H., Buchholz, V., Hussein, R., Bleich, S., Meyer, C., John, U., Bischof, A., & Rumpf, H. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.05.013 · Cited by 45 · see citing works
Mindfulness-Based Interventions Applied to Addiction Treatments
Kechter, A., & Black, D. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.040 · Cited by 43 · see citing works
Multiple Memory Systems, Addiction, and Health Habits: New Routes for Translational Science
Stacy, A. W., Pike, J. R., & Lee, A. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.017 · Cited by 43 · see citing works
Tanning as an Addiction: The State of the Research and Implications for Intervention
Miller, K. A., & Mays, D. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.037 · Cited by 43 · see citing works
Schulte, E. M., Schiestl, E. T., & Gearhardt, A. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.035 · Cited by 43 · see citing works
Behavioral Economics and Addictive Disorders
Jarmolowicz, D. P., & Schneider, T. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.005 · Cited by 42 · see citing works
Prevention and Treatment of Compulsive Buying Disorder
Galimov, A., & Black, D. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.027 · Cited by 42 · see citing works
Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D. A., Thanos, P. K., Lott, L., Badgaiyan, S., et al. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.031 · Cited by 42 · see citing works
Prevention and Treatment of “Food Addiction”
Davis, C., & Mason, A. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.023 · Cited by 42 · see citing works
Human Neurobiological Approaches to Hedonically Motivated Behaviors
Burger, K. S., Shearrer, G. E., & Sadler, J. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.009 · Cited by 42 · see citing works
Feedback Models for Gambling Control: The Use and Efficacy of Online Responsible Gambling Tools
Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.034 · Cited by 42 · see citing works
Striatal presynaptic dopaminergic dysfunction in gambling disorder: A 123 I‐FP‐CIT SPECT study
Pettorruso, M., Martinotti, G., Cocciolillo, F., Risio, L. D., Cinquino, A., Nicola, M. D., Camardese, G., Migliara, G., Moccia, L., Conte, E., et al. (2018) · Addiction Biology · doi:10.1111/adb.12677 · Cited by 44 · see citing works
Ferland, J. N., Hynes, T. J., Hounjet, C. D., Lindenbach, D., Haar, C. V., Adams, W. K., Phillips, A. G., & Winstanley, C. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.3477-17.2018 · Cited by 41 · see citing works
Jara-Rizzo, M. F., Navas, J. F., Catena, A., & Perales, J. C. (2019) · Journal of Gambling Studies · doi:10.1007/s10899-019-09868-7 · Cited by 40 · see citing works
Quaglieri, A., Mari, E., Boccia, M., Piccardi, L., Guariglia, C., & Giannini, A. M. (2020) · Brain Sciences · doi:10.3390/brainsci10060353 · Cited by 39 · see citing works
Common neurobiological and psychological underpinnings of gambling and substance-use disorders
Balodis, I. M., & Potenza, M. N. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109847 · Cited by 37 · see citing works
Malén, T., Karjalainen, T., Isojärvi, J., Vehtari, A., Bürkner, P.-C., Putkinen, V., Kaasinen, V., Hietala, J., Nuutila, P., Rinne, J., et al. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119149 · Cited by 32 · see citing works
Joutsa, J., Karlsson, H. K., Majuri, J., Nuutila, P., Helin, S., Kaasinen, V., & Nummenmaa, L. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.03.006 · Cited by 35 · see citing works
Evidence for GABA‐A receptor dysregulation in gambling disorder: correlation with impulsivity
Mick, I., Ramos, A. C., Myers, J., Stokes, P. R. A., Chandrasekera, S., Erritzøe, D., Méndez, M. A., Gunn, R. N., Rabiner, E. A., Searle, G. E., et al. (2016) · Addiction Biology · doi:10.1111/adb.12457 · Cited by 35 · see citing works
Self-citationJanssen, L. K., Sescousse, G., Hashemi, M. M., Timmer, M. H. M., ter Huurne, N. P., Geurts, D. E. M., & Cools, R. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3986-y · Cited by 35 · see citing works
Boileau, I., Nakajima, S., & Payer, D. E. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.06.002 · Cited by 34 · see citing works
Exploring dopaminergic transmission in gambling addiction: A systematic translational review
Pettorruso, M., Zoratto, F., Miuli, A., Risio, L. D., Santorelli, M., Pierotti, A., Martinotti, G., Adriani, W., & Giannantonio, M. D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.034 · Cited by 36 · see citing works
Impulsivity in abstinent alcohol and polydrug dependence: a multidimensional approach
Platform, I., Taylor, E., Murphy, A., Boyapati, V., Ersche, K. D., Flechais, R., Kuchibatla, S., McGonigle, J., Metastasio, A., Nestor, L. J., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4245-6 · Cited by 31 · see citing works
Self-citationPlatform, I., Murphy, A., Nestor, L. J., McGonigle, J., Paterson, L. M., Boyapati, V., Ersche, K. D., Flechais, R., Kuchibatla, S., Metastasio, A., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.289 · Cited by 33 · see citing works
Self-citationPlatform, I., Murphy, A., Nestor, L. J., McGonigle, J., Paterson, L. M., Boyapati, V., Ersche, K. D., Flechais, R., Kuchibatla, S., Metastasio, A., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.99 · Cited by 33 · see citing works
Self-citationSchluter, M. G., Kim, H. S. A., & Hodgins, D. C. (2018) · Journal of Behavioral Addictions · doi:10.1556/2006.7.2018.117 · Cited by 32 · see citing works
Integrating Preclinical and Clinical Models of Negative Urgency
Halcomb, M., Argyriou, E., & Cyders, M. A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00324 · Cited by 34 · see citing works
Turton, S., Myers, J. F., Mick, I., Colasanti, A., Venkataraman, A. V., Durant, C. F., Waldman, A. D., Brailsford, A. D., Parkin, M. C., Dawe, G., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0107-4 · Cited by 32 · see citing works
Self-citationLinnet, J. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109802 · Cited by 33 · see citing works
The neural basis of gambling disorder: An activation likelihood estimation meta-analysis
Raimo, S., Cropano, M., Trojano, L., & Santangelo, G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.027 · Cited by 30 · see citing works
Gambling Dual Disorder: A Dual Disorder and Clinical Neuroscience Perspective
Szerman, N., Ferre, F., Basurte-Villamor, I., Vega, P., Mesías, B., Marín-Navarrete, R., & Arango, C. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.589155 · Cited by 30 · see citing works
Romo, L., Legauffre, C., Guilleux, A., Valleur, M., Magalon, D., Fatseas, M., Chéreau, I., Luquiens, A., Vénisse, J.-L., _, _., et al. (2016) · Journal of Behavioral Addictions · doi:10.1556/2006.5.2016.070 · Cited by 28 · see citing works
Jara-Rizzo, M. F., Navas, J. F., Steward, T., López-Gómez, M., Jiménez‐Múrcia, S., Fernández‐Aranda, F., & Perales, J. C. (2018) · Adicciones · doi:10.20882/adicciones.1041 · Cited by 28 · see citing works
Newberry, M. (2017) · Psychology Crime and Law · doi:10.1080/1068316x.2017.1371305 · Cited by 27 · see citing works
Brain Imaging in Gambling Disorder
Quester, S., & Romanczuk‐Seiferth, N. (2015) · Current Addiction Reports · doi:10.1007/s40429-015-0063-x · Cited by 27 · see citing works
The Iowa Gambling Task and the three fallacies of dopamine in gambling disorder
Linnet, J. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00709 · Cited by 28 · see citing works
Dopamine and Risky Decision-Making in Gambling Disorder
Peters, J., Vega, T. A., Weinstein, D., Mitchell, J. M., & Kayser, A. S. (2020) · eNeuro · doi:10.1523/eneuro.0461-19.2020 · Cited by 22 · see citing works
Wolfschlag, M., & Håkansson, A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252516 · Cited by 24 · see citing works
Drug-Induced Gambling Disorder: Epidemiology, Neurobiology, and Management
Wolfschlag, M., & Håkansson, A. (2023) · Pharmaceutical Medicine · doi:10.1007/s40290-022-00453-9 · Cited by 25 · see citing works
Peng, Z., Jia, Q., Mao, J., Luo, X., Huang, A., Zheng, H., Jiang, S., Ma, Q., Ma, C., & Yi, Q. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1439727 · Cited by 22 · see citing works
- Authors
- Clark, L., Stokes, P. R., Wu, K., Michalczuk, R., Benecke, A., Watson, B. J., Egerton, A., Piccini, P., Nutt, D. J., Bowden-Jones, H., & Lingford-Hughes, A. R.
- Affiliations
- University of Cambridge (GB)
- Imperial College London (GB)
- University of Bristol (GB)
- King's College London (GB)
- Central and North West London NHS Foundation Trust (GB)
- Corresponding author
- Clark, Luke
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 63
- Issue
- 1
- Pages
- 40-46
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3438449
- OpenAlex
- W2084587642
- Cited by
- 193
- References
- 65
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 11 · 2022: 4 · 2021: 3 · 2020: 55 · 2019: 13 · 2018: 14 · 2017: 10 · 2016: 17 · 2015: 21 · 2014: 15 · 2013: 15 · 2012: 3
- FWCI
- 19.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- NeuroImage (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- Medical Research Council (G0400575, G0802725)
- Responsible Gambling Fund
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- gambling addiction, dopamine D2/D3 receptors, impulsivity, urgency, [11C]raclopride PET, behavioral addiction, dopamine dysregulation
- MeSH terms
- Adult, Affect, Corpus Striatum, Female, Gambling, Humans, Impulsive Behavior, Male, Middle Aged, Statistics as Topic, Receptors, Dopamine D2, Positron-Emission Tomography, Receptors, Dopamine D3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
