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Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines
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BACE1 inhibition increases ADAM10 cleavage of APP, such that total APP cleavage is only mildly reduced.
“One example is APP. BACE1 inhibition increases the ADAM10 cleavage of APP, such that total APP cleavage is only mildly reduced [36, 47].”
From Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons (2016) · cites this paper as [36]
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Intracellular amyloid-β in Alzheimer's disease
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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., et al. (2012) · Nature · doi:10.1038/nature11283 · Cited by 1,738
Kuhn, P., Wang, H., Dislich, B., Colombo, A., Zeitschel, U., Ellwart, J. W., Kremmer, E., Roßner, S., & Lichtenthaler, S. F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.167 · Cited by 621 · cited 15×
“In fact, pharmacological inhibition of α-secretase may not increase APPsβ and Aβ levels (Kim et al., 2008; Kuhn et al., 2010; Marcello et al., 2007).”
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Human secreted tau increases amyloid-beta production
Bright, J., Hussain, S., Dang, V., Wright, S., Cooper, B., Byun, T., Ramos, C., Singh, A., Parry, G., Stagliano, N., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.007 · Cited by 230
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Pigoni, M., Wanngren, J., Kuhn, P.-H., Munro, K. M., Gunnersen, J. M., Takeshima, H., Feederle, R., Voytyuk, I., De Strooper, B., Levasseur, M. D., et al. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0134-z · Cited by 125
Self-citation
Metadata
- Authors
- Colombo, A., Wang, H., Kuhn, P.-H., Page, R., Kremmer, E., Dempsey, P. J., Crawford, H. C., & Lichtenthaler, S. F.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 49
- Pages
- 137-147
- ISSN
- 0969-9961
- PMC
- PMC4310234
- Cited by
- 62
- References
- 3
- Language
- en
- Funders
- Deutsche Forschungsgemeinschaft (SFB596 project B12)
- competence network degenerative dementias (BMBF) (project Z2)
- Chinese Scholarship Council
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