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NLRP3 Inflammasome Activation Enhances ADK Expression to Accelerate Epilepsy in Mice

Zhang, H., Yu, S., Xia, L., Xia, P., Wang, S., & Yao, B. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03479-8 · Cited by 29 · see citing works

Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease

Chakraborty, S., Cheng, B. Y.-L., Edwards, D. L., González, J. C., Chiu, D. K., Zheng, H., Scallan, C., Guo, X., Tan, G. S., Coffey, G., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.10.002 · Cited by 23 · see citing works

The interplay between metabolism and neuroinflammation in epilepsy: mechanisms and therapeutic perspectives

Xu, L., Zhao, Z., Zhang, Y., & Ma, C.-L. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03553-w · Cited by 27 · see citing works

The potential roles of excitatory-inhibitory imbalances and the repressor element-1 silencing transcription factor in aging and aging-associated diseases

Ghosh, I., Liu, C. S., Swardfager, W., Lanctôt, K. L., & Anderson, N. D. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103683 · Cited by 20 · see citing works

Serum-Based Biomarkers in Neurodegeneration and Multiple Sclerosis

LoPresti, P. (2022) · Biomedicines · doi:10.3390/biomedicines10051077 · Cited by 21 · see citing works

Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia

Johnston, J. L., Reda, S. M., Setti, S. E., Taylor, R. W., Berthiaume, A.-A., Walker, W. E., Wu, W., Moebius, H. J., & Church, K. J. (2023) · Neurotherapeutics · doi:10.1007/s13311-022-01325-5 · Cited by 18 · see citing works

Immune synaptopathies: how maternal immune activation impacts synaptic function during development

Matteoli, M., Pozzi, D., Fossati, M., & Menna, E. (2023) · The EMBO Journal · doi:10.15252/embj.2023113796 · Cited by 16 · see citing works

Pharmacological Inhibition of Spleen Tyrosine Kinase Suppressed Neuroinflammation and Cognitive Dysfunction in LPS-Induced Neurodegeneration Model

Kim, M. W., Choe, K., Park, J. S., Lee, H. J., Kang, M. H., Ahmad, R., & Kim, M. O. (2022) · Cells · doi:10.3390/cells11111777 · Cited by 16 · see citing works

Astrocytic transcription factors REST, YY1, and putative microRNAs in Parkinson’s disease and advanced therapeutic strategies

Nassar, A., Kodi, T., Satarker, S., Gurram, P. C., Fayaz, S. M., & Nampoothiri, M. (2023) · Gene · doi:10.1016/j.gene.2023.147898 · Cited by 14 · see citing works

Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms

Baram, T. Z., & Birnie, M. T. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100669 · Cited by 16 · see citing works

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

Santos, A. B., Carona, A., Ettcheto, M., Camins, A., Falcão, A. C., Fortuna, A. C., & Bicker, J. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01285-w · Cited by 12 · see citing works

Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Blood–Brain Barrier Damage Relevant to NeuroCOVID Brain Inflammation

Chiang, W., Stout, A., Yanchik-Slade, F., Li, H., Terrando, N., Nilsson, B. L., Gelbard, H. A., & Krauss, T. D. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c02719 · Cited by 9 · see citing works

Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems

Tian, C., Ao, Z., Cerneckis, J., Cai, H., Chen, L., Niu, H., Takayama, K., Kim, J., Shi, Y., Gu, M., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu2708 · Cited by 9 · see citing works

The metabaging cycle promotes non‐metabolic chronic diseases of ageing

Cheng, Y., Liu, R., Wang, R. R., Yu, K., Shen, J., Pang, J., Zhang, T., Shi, H., Sun, L., & Shyh‐Chang, N. (2024) · Cell Proliferation · doi:10.1111/cpr.13712 · Cited by 9 · see citing works

MicroRNA biogenesis machinery activation and lncRNA and REST overexpression as neuroprotective responses to fight inflammation in the hippocampus

Carvalho, L. B., Sanna, P. L. D. S., Afonso, C. C. D. S., Bondan, E. F., Feltran, G. D. S., Ferreira, M. R., Birbrair, A., Andia, D. C., Latini, A., & da Silva, R. A. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578149 · Cited by 9 · see citing works

Modulation of the central nervous system immune response and neuroinflammation via Wnt signaling in health and neurodegenerative diseases

Fang, K. (2024) · Ibrain · doi:10.1002/ibra.12185 · Cited by 10 · see citing works

The Regulatory Roles of REST in the Synaptic Development, Function and Related Neurological Disorders

Lim, C. T., Lim, C. W., Huang, T., Ismail, E. N., Reisi, P., Cheah, P.-S., & Ling, K. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70132 · Cited by 5 · see citing works

Upregulation of miR‐22‐3p Alleviates Hyperalgesia and Neuroinflammation Caused by Migraine

Yang, L., Li, F., Guo, L., Qi, S., & Liu, P. (2025) · Synapse · doi:10.1002/syn.70017 · Cited by 5 · see citing works

Parental Preconception and Pre-Hatch Exposure to a Developmental Insult Alters Offspring’s Gene Expression and Epigenetic Regulations: An Avian Model

Rimawi, I., Turgeman, G., Avital-Cohen, N., Rozenboim, I., & Yanai, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24055047 · Cited by 4 · see citing works

Harnessing metabolic control for synaptic stability: REST/NRSF links glycolytic inhibition to excitatory neurotransmission

Ferrante, D., Parisi, B., Marte, A., Marianna, D., Prestigio, C., Benzi, A., Bruzzone, S., Benfenati, F., Onofri, F., Valente, P., et al. (2025) · The Journal of Physiology · doi:10.1113/jp288763 · Cited by 4 · see citing works

Targeting the C5-C5aR1 axis: A promising therapeutic strategy for Alzheimer’s disease and amyotrophic lateral sclerosis by unlocking neuroprotection

Ge, T.-Q., Wang, P., & Guan, P.-P. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117518 · Cited by 4 · see citing works

Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosis in EAE mice

Qin, H., Yang, L., Du, J., Xu, X., Chen, Z., Li, Q., Xu, Y., Li, M., Li, Y., & Jia, Y. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116364 · Cited by 4 · see citing works

Overexpression of REST Causes Neuronal Injury and Decreases Cofilin Phosphorylation in Mice

Liu, X., Yan, J., Liu, F., Zhou, P., Lv, X., Cheng, N., & Liu, L. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-210285 · Cited by 4 · see citing works

Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells

Kang, M., Jin, N., Park, S., & Han, J. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119361 · Cited by 4 · see citing works

Promotive effect of skin precursor-derived Schwann cells on brachial plexus neurotomy and motor neuron damage repair through milieu-regulating secretome

Chen, J.-N., Yang, X., Meng, C., Zhu, L.-J., Wu, X., Wang, L., Sha, L., Yu, Y. Y., He, Q., Ding, F., et al. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.04.002 · Cited by 4 · see citing works

KCC2 Dysfunction Mediated by Microglial BDNF / TrkB Signaling Exacerbates Early Post‐Stroke Seizure Susceptibility

Zhou, J., Wang, B. H., Yu, J., Wang, G., Cai, J., Yu, M., Chen, K., Wan, L., Liu, X., Yang, Z., et al. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.70795 · Cited by 4 · see citing works

Molecular Mechanisms of Hippocampal Synaptic Plasticity Disruption Induced by Chronic Methamphetamine Exposure: A Narrative Review

Hedayati‐Moghadam, M., Razazpour, F., Hakemi, Z., Khani, F., & Baghcheghi, Y. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01747-1 · Cited by 3 · see citing works

Exploring the spectrum of heroin-induced changes in the rat brain

Shirvani, P., Shirvani, P., Moteshakereh, S. M., Lajevardi, Z., Nourirad, S. N., Amini, N. B., Niakan, Z., Parvardeh, S., Bayat, A., Hajibeygi, R., et al. (2025) · 3 Biotech · doi:10.1007/s13205-025-04387-2 · Cited by 3 · see citing works

Deciphering the molecular mechanism of REST regulation through DEGs and TFs in Alzheimer's disease

Nassar, A., Nampoothiri, M., Gurram, P. C., Satarker, S., Upadhya, D., Shamabhat, G., & Mahammad, F. S. (2023) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2023.152245 · Cited by 3 · see citing works

Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human brain organoid microphysiological systemsPreprint

Tian, C., Ao, Z., Cerneckis, J., Cai, H., Chen, L., Niu, H., Takayama, K., Kim, J., Shi, Y., Gu, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.16.638539 · Cited by 3 · see citing works

The Dynamic Roles of Repressor Element 1-Silencing Transcription Factor (REST): A Double-Edged Sword in Neural Health and Disease

Eva, T. A., Shenoy, A., Gupta, V. B., Palanivel, V., Salkar, A., Nasab, S. N., Chitranshi, N., Mirzaei, M., You, Y., Graham, S. L., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05304-7 · Cited by 2 · see citing works

The Potential Protective Effects of EGCG Against Epilepsy‐Induced Damage in Rats by Mitigating Oxidative Stress, Inflammation, and Apoptosis

Alatawi, S. A. M., Albalawi, M., Alfaifi, R. M., Al-Twalhy, R., Al-Johani, M. D., Alanazi, D. A., Al-Otaibi, R. M., Hassan, H. M., & Al-Gayyar, M. M. H. (2025) · Scientifica · doi:10.1155/sci5/8209714 · Cited by 2 · see citing works

The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes

Huang, T., Fakurazi, S., Cheah, P.-S., & Ling, K. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1552819 · Cited by 2 · see citing works

The genetic face of brain diseases

Shehryar, Z. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28822-7.00012-x · Cited by 1 · see citing works

Pinealectomy-Induced Neuroinflammation Varies with Age in Rats

Atanasova, D., Krushovlieva, D., Rashev, P., Mourdjeva, M., Pupaki, D. V., & Tchekalarova, J. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168093 · Cited by 1 · see citing works

Hippocampal miR-124 mediates depression-like behavior via the USP14/REST signaling pathway in CRS- and CUMS-induced mouse models

Xie, H., Xue, Y., Deng, R., Chen, L., Wang, Y., Xu, J., Liu, H., Li, X., Cui, W., & Zhang, J. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120841 · Cited by 1 · see citing works

Association of neurocan and microglial functional state following intracerebral hemorrhage

Zhang, X., Li, Z., Hagen, K. M., Yong, V. W., & Xue, M. (2026) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2026.100294 · Cited by 1 · see citing works

A thermally actuated 3D foldable bioelectronic interface for multimodal electrophysiological and cytokine profiling of human spinal cord organoids

Lee, S., Han, S. M., Shin, H., Lee, J., & Chou, N. (2026) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2026.118950 · Cited by 1 · see citing works

Homocysteine‐potentiated Kelch‐like ECH‐associated protein 1 promotes senescence of neuroblastoma 2a cells via inhibiting ubiquitination of β‐catenin

Zhang, Y., Xie, J., Jiang, Y., Yang, S., Wei, H., Yang, Y., & Wang, J. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16318 · Cited by 1 · see citing works

A Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Dysregulation of the Neurovascular Unit Relevant to Brain InflammationPreprint

Chiang, W., Stout, A., Yanchik-Slade, F., Li, H., Nilsson, B. L., Gelbard, H. A., & Krauss, T. D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.20.488933 · Cited by 1 · see citing works

NRSF Negatively Regulates Microglial Pro-Inflammatory Activation

Yu, M., Wang, P., Li, B., Ruan, Q., ZhangBao, J., Wu, L., Zhang, X., Liu, Z., & Huang, F. (2024) · doi:10.60124/j.pneuro.2024.20.02

Distribution Characteristics and Functional Prediction of NLRP3 Polymorphism in Children with Allergic Rhinitis

Cai, X., Yin, T., Wang, J., & Mu, Q. (2025) · International Archives of Allergy and Immunology · doi:10.1159/000547060

Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron–microglia co-culture modelPreprint

Siedlecki‐Wullich, D., Ayral, A., Iohan, L. D. C. C., Lemeu, C., Buiche, V., Blary, K., Chapuis, J., Eysert, F., Beury, D., Delacre, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.19.671013

Metabolic syndrome, depression, and omega-3 polyunsaturated fatty acids

Serhiyenko, A. A., Hotsko, M. E., Oliinyk, A. Y., & Serhiyenko, V. A. (2025) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.21.8.2025.1662

Inflammatory stimulus enhances synaptic material uptake by adult APP microglia in a microfluidic neuron–microglia co-culture model

Siedlecki‐Wullich, D., Ayral, A., Iohan, L. D. C. C., Lemeu, C., Buiche, V., Blary, K., Chapuis, J., Eysert, F., Beury, D., Delacre, M., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03748-9

REST-AKT-SOX2 axis controls neuronal lineage state and Midkine-mediated communication in SHH-medulloblastomaPreprint

Singh, A., Guo, L., Swaminathan, J., Cheng, D., Yang, Y., Manickavinayaham, S., Xu, L., & Gopalakrishnan, V. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.06.716597

The neuroimmune-glutamate hypothesis of addiction

Gipson, C. D., White, A. M., Richie, D. L., McNealy, K. R., Stoops, W. W., & Ornelas, L. C. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106859

Repressor Element 1 Silencing Transcription Factor as a central regulator of autophagy and neuroinflammation in Alzheimer's disease

Dilip, P. I., Daksh, R., Sharma, P., Khanna, S., Bojja, S. L., Singh, A. K., & Nampoothiri, M. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179168

Neurons as cytokine sensors in the central nervous system

Kahn, A., Binkle-Ladisch, L., Sonner, J. K., & Friese, M. A. (2026) · Trends in Immunology · doi:10.1016/j.it.2026.07.012

Combined low-dose (2R,6R)-Hydroxynorketamine and memantine restore BDNF/TrkB signaling and synaptic function in an LPS-induced model of depressive-like behavior in male mice

Jia, X., Gong, Q., Xiong, B., Hu, Y., Ali, T., Zheng, C., Wei, S., Huang, J., Wang, Z., Feng, J., et al. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106988

Phosphorylation by CaMKIV regulates the transcriptional repressor activity and half-life of REST/NRSF

Tsushima, H., Corradi, B., Canevari, C., Shmal, D., Chiacchiaretta, M., Liessi, N., Fonzo, A. D., Carminati, E., Armirotti, A., Fassio, A., et al. (2026) · Science Advances · doi:10.1126/sciadv.aec0781

In vitro and in vivo characterization of the RE-1 Silencing Transcription Factor (REST) activity under neuroinflammatory conditions

Buffolo, F. (2019) · CINECA IRIS Institutial Research Information System (University of Genoa) · doi:10.15167/buffolo-federica_phd2019-02-21

Synapse Loss Induced by Interleukin-1β Requires Pre- and Post-synaptic Mechanisms

Mishra, A., Kim, H. J., Shin, A. H., & Thayer, S. A. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9342-7 · Cited by 131 · see citing works

Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation

Rizzo, F. R., Musella, A., Vito, F. D., Fresegna, D., Bullitta, S., Vanni, V., Guadalupi, L., Bassi, M. S., Buttari, F., Mandolesi, G., et al. (2018) · Neural Plasticity · doi:10.1155/2018/8430123 · Cited by 213 · see citing works

miR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation

Mandolesi, G., Vito, F. D., Musella, A., Gentile, A., Bullitta, S., Fresegna, D., Sepman, H., Sanza, C. D., Haji, N., Mori, F., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0851-16.2016 · Cited by 116 · see citing works

Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1β via p38 Mitogen-Activated Protein Kinase

Tong, L., Prieto, G. A., Kramár, E. A., Smith, E. D., Cribbs, D. H., Lynch, G., & Cotman, C. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1253-12.2012 · Cited by 254 · see citing works