The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc
Open accessAbstract
Long non-coding RNAs (lncRNAs) represent an emerging layer of cancer biology, contributing to tumor proliferation, invasion, and metastasis. Here, we describe a role for the oncogenic lncRNA PCAT-1 in prostate cancer proliferation through cMyc. We find that PCAT-1-mediated proliferation is dependent on cMyc protein stabilization, and using expression profiling, we observed that cMyc is required for a subset of PCAT-1-induced expression changes. The PCAT-1-cMyc relationship is mediated through the post-transcriptional activity of the MYC 3' untranslated region, and we characterize a role for PCAT-1 in the disruption of MYC-targeting microRNAs. To further elucidate a role for post-transcriptional regulation, we demonstrate that targeting PCAT-1 with miR-3667-3p, which does not target MYC, is able to reverse the stabilization of cMyc by PCAT-1. This work establishes a basis for the oncogenic role of PCAT-1 in cancer cell proliferation and is the first study to implicate lncRNAs in the regulation of cMyc in prostate cancer.
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Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011) · Cell · doi:10.1016/j.cell.2011.07.014 · Cited by 7,262
Landscape of transcription in human cells
Djebali, S., Davis, C. A., Merkel, A., Dobin, A., Lassmann, T., Mortazavi, A., Tanzer, A., Lagarde, J., Lin, W., Schlesinger, F., et al. (2012) · Nature · doi:10.1038/nature11233 · Cited by 5,187
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017
Self-citationLong Noncoding RNAs with Enhancer-like Function in Human Cells
Ørom, U. A., Derrien, T., Beringer, M., Gumireddy, K., Gardini, A., Bussotti, G., Lai, F., Zytnicki, M., Notredame, C., Huang, Q., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.001 · Cited by 1,721
Reflecting on 25 years with MYC
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The Role of Myc-Induced Protein Synthesis in Cancer
Ruggero, D. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1970 · Cited by 186
The role of c-myc in regulation of translation initiation
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“Conversely, analysis of 93 genes upregulated by PCAT-1 and dependent on cMyc demonstrated an enrichment of genes involved in protein biosynthesis and transcriptional elongation, welldescribed functions of cMyc (Table W3) [20,21].”
Background
Cited by
The emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
Analyzing MiRNA–LncRNA Interactions
Paraskevopoulou, M. D., & Hatzigeorgiou, A. G. (2016) · Methods in Molecular Biology · doi:10.1007/978-1-4939-3378-5_21 · Cited by 895
Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer
Quigley, D. A., Dang, H. X., Zhao, S. G., Lloyd, P., Aggarwal, R., Alumkal, J. J., Foye, A., Kothari, V., Perry, M. D., Bailey, A. M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.039 · Cited by 733
Self-citationLong Noncoding RNAs as Biomarkers in Cancer
Bolha, L., Ravnik-Glavač, M., & Glavač, D. (2017) · Disease Markers · doi:10.1155/2017/7243968 · Cited by 365
MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches
Amodio, N., Raimondi, L., Juli, G., Stamato, M. A., Caracciolo, D., Tagliaferri, P., & Tassone, P. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0606-4 · Cited by 348
Metadata
- Authors
- Prensner, J. R., Chen, W., Han, S., Iyer, M. K., Cao, Q., Kothari, V., Evans, J. R., Knudsen, K. E., Paulsen, M. T., Ljungman, M., Lawrence, T. S., Chinnaiyan, A. M., & Feng, F. Y.
- Venue
- Neoplasia
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 16
- Issue
- 11
- Pages
- 900-908
- ISSN
- 1476-5586 (ISSN-L)
- OpenAlex
- W2153248764
- Cited by
- 256
- References
- 8
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Prensner, J. R., Chen, W., Han, S., Iyer, M. K., Cao, Q., Kothari, V., Evans, J. R., Knudsen, K. E., Paulsen, M. T., Ljungman, M., Lawrence, T. S., Chinnaiyan, A. M., & Feng, F. Y. (2014). The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc. Neoplasia. https://doi.org/10.1016/j.neo.2014.09.001
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