The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory
Abstract
Because of its reliance on memory, the tendency for rats, mice and other animals to alternate successive choices of T- or Y-maze arms has assumed considerable popularity in pharmacological studies of spatial memory as a quick and simple measure of retention that avoids the need for extensive training and the use of conventional reinforcers. Two forms of this tendency have been utilized, namely two-trial and continuous spontaneous alternation behavior (SAB). However, as the behavior can also reflect drug-related changes in sensory/attentional, motivational and performance processes, SAB should not be unquestionably accepted as a measure of memory alone. While assessments of post-acquisition drug effects on longer term memory may be possible through the appropriate timing of drug administration, this is more problematic if SAB is used as a measure of shorter term memory. Even though SAB can be a useful index of responsiveness to novelty, its value as a measure of retention is less certain. In this latter respect, a possible alternative to SAB testing might be the recently developed form of the related procedure, responsiveness to change.
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In the citing paper
“A symmetrical Y maze was used to evaluate spatial working memory [49].”
From Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology (2016) · cites this paper as [49]
In the citing paper
“If a mouse remained immobile or failed to explore all three arms, it was excluded from the study61.”
From MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity (2025) · cites this paper as [61]
Citations
Cites
Spatial localization does not require the presence of local cues
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Berlyne, D. E., Fiske, D. W., & Maddi, S. R. (1963) · The American Journal of Psychology · doi:10.2307/1419183 · Cited by 1,114
The neurobiological basis of spontaneous alternation
Lalonde, R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00041-0 · Cited by 857
Walker, D. L., Ressler, K. J., Lu, K.-T., & Davis, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02343.2002 · Cited by 815
Validity of head-dipping as a measure of exploration in a modified hole-board
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Islam and Liberal Democracy: A Historical Overview
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Research works printed but not linked: 2
- Douglas, 1975, vol. 2, 327
- Hagan, 1988, vol. 20, 237
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Regulation of Tau Pathology by the Microglial Fractalkine Receptor
Bhaskar, K., Konerth, M., Kokiko-Cochran, O. N., Cardona, A., Ransohoff, R. M., & Lamb, B. T. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.023 · Cited by 639
“Behavioral Analysis A symmetrical Y maze was used to evaluate spatial working memory (Hughes, 2004).”
SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
Michan, S., Li, Y., Chou, M. M.-H., Parrella, E., Ge, H., Long, J. M., Allard, J. S., Lewis, K., Miller, M., Xu, W., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0027-10.2010 · Cited by 541
“The percentage of alternations per total entries was then calculated (Hughes, 2004).”
MethodMa, Q.-L., Yang, F., Rosario, E. R., Ubeda, O. J., Beech, W., Gant, D. J., Chen, P. P., Hudspeth, B., Chen, C., Zhao, Y., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1071-09.2009 · Cited by 536
“fully isolate memory from other causes of behavioral defects, deficits in working memory measured with SAB in the Y-maze have been widely used to identify cognitive deficits in different transgenic AD mouse models (Hughes, 2004), including APPsw Tg2576 mice (King and Arendash, 2002; Ognibene et al.”
MethodLactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing
Newman, L. A., Korol, D. L., & Gold, P. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028427 · Cited by 492
Bilousova, T. V., Dansie, L., Ngo, M., Aye, J., Charles, J. R., Ethell, D. W., & Ethell, I. M. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.061796 · Cited by 465
Metadata
- Authors
- Hughes, R. N.
- Affiliations
- University of Canterbury (NZ)
- Corresponding author
- Hughes, Robert N.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 28
- Issue
- 5
- Pages
- 497-505
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2143302321
- Cited by
- 641
- References
- 116
- Citations by year
- 2026: 37 · 2025: 47 · 2024: 38 · 2023: 39 · 2022: 54 · 2021: 45 · 2020: 55 · 2019: 41 · 2018: 35 · 2017: 38 · 2016: 28 · 2015: 18 · 2014: 26 · 2013: 24 · 2012: 24
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
- Keywords
- spatial memory, memory retention, T-maze, Y-maze, responsiveness to change, drug effects on memory, attentional processes, motivation
- MeSH terms
- Acetylcholine, Animals, Attention, Behavior, Animal, Brain Chemistry, Humans, Light, Memory, Reinforcement, Psychology, Smell, Space Perception
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