The DOI matches its Crossref record; 243 of the 243 references it cites were found in a registry or an index.
AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine
Open accessAbstract
This review focuses on cocaine-induced postsynaptic plasticity in the nucleus accumbens (NAc) involving changes in AMPA receptor (AMPAR) transmission. First, fundamental properties of AMPAR in the NAc are reviewed. Then, we provide a detailed and critical analysis of literature demonstrating alterations in AMPAR transmission in association with behavioral sensitization to cocaine and cocaine self-administration. We conclude that cocaine exposure leads to changes in AMPAR transmission that depend on many factors including whether exposure is contingent or non-contingent, the duration of withdrawal, and whether extinction training has occurred. The relationship between changes in AMPAR transmission and responding to cocaine or cocaine-paired cues can also be affected by these variables. However, after prolonged withdrawal in the absence of extinction training, our findings and others lead us to propose that AMPAR transmission is enhanced, resulting in stronger responding to drug-paired cues. Finally, many results indicate that the state of synaptic transmission in the NAc after cocaine exposure is associated with impairment of AMPAR-dependent plasticity. This may contribute to a broad range of addiction-related behavioral changes.
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“Key synaptic changes involve glutamate-modulated N-methyl-D-aspartate (NMDA) receptors and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in glutamatergic projections from the prefrontal cortex and amygdala to the ventral tegmental area and nucleus accumbens (table 2, circuit 4).”
From Neurobiology of addiction: a neurocircuitry analysis (2016) · cites this paper as [46]
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In the citing paper
“These early drug-evoked changes in the properties of excitatory synapses on dopamine cells can be very long-lasting and are followed by many additional synaptic modifications in related structures.”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Wolf and Ferrario 2010
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“For example, in the nucleus accumbens chronic (5-d) administration of cocaine triggers an internalization of AMPARs in medium spiny neurons, a change that occludes the subsequent synaptic induction of NMDARdependent LTD (Thomas and Malenka 2003;Kauer and Malenka 2007;Wolf and Ferrario 2010).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Wolf and Ferrario 2010
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Metadata
- Authors
- Wolf, M. E., & Ferrario, C. R.
- Affiliations
- Rosalind Franklin University of Medicine and Science (US)
- Corresponding author
- Wolf, Marina E.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 35
- Issue
- 2
- Pages
- 185-211
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC2962767
- OpenAlex
- W2056862933
- Semantic Scholar
- 6ab929dc5b23235ebacfbbbeb99831a37c68d68c
- Cited by
- 271
- References
- 243
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 12 · 2022: 12 · 2021: 12 · 2020: 15 · 2019: 11 · 2018: 16 · 2017: 16 · 2016: 22 · 2015: 16 · 2014: 19 · 2013: 34 · 2012: 34
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (DA009621, K02DA000453, DA024502, DA015835, DA000453, K05DA029099, F32DA024502, R01DA015835, R37DA015835, R01DA009621)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- AMPA receptors, nucleus accumbens, cocaine, postsynaptic plasticity, behavioral sensitization, cocaine self-administration, cocaine withdrawal, extinction training, addiction, synaptic transmission
- MeSH terms
- Animals, Behavior, Animal, Cocaine, Neuronal Plasticity, Nucleus Accumbens, Self Administration, Receptors, AMPA
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