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Cited by 52Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice

Mead, Andy N., Brown, Geraldine, Le Merrer, Julie, Stephens, David N.·2005·Psychopharmacology
DOI 10.1007/s00213-004-2071-8
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Abstract

Rationale The conditioned place preference (CPP) paradigm has been used as a measure of the rewarding effects of a number of stimuli. Critically, this classical conditioning procedure requires the formation of associations between a rewarding stimulus and environmental cues, and the ability of these cues to direct subsequent behaviour.Objectives The purpose of the current experiments was to examine the role of glutamatergic transmission via subunit-specific populations of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors in the formation of stimulus--reward associations involving contextual stimuli.Methods We investigated the ability of cocaine and food to induce a CPP in mice lacking either the GluR1 or GluR2 subunits of the AMPA receptor [gria1 or gria2 knockout (KO) mice]. In separate experiments, food pellets or cocaine (5--20 mg/kg IP) were paired with one compartment of the CPP apparatus, while no-food or vehicle was paired with an alternative compartment.Results Following conditioning, gria1 KOs displayed a significant preference for the food or cocaine-paired compartment, and did not differ from wild-type (WT) controls. However, gria2 knockouts displayed a preference for a cocaine-paired compartment, but not a food-paired compartment, indicating a specific deficit in place preference conditioning to food.Conclusions These results obtained using knockout mice indicate that GluR2-containing AMPA receptors may be critical for learning about contextual stimuli relevant to food rewards, but not drug rewards. When the results are considered in relation to our previous findings with gria1 and gria2 knockout mice, they also raise questions about the CPP paradigm representing a model of conditioned reward over a conditioned approach interpretation. However, it would be important to confirm these findings with alternative approaches, should selective ligands become available.

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Authors
Mead, A. N., Brown, G., Le Merrer, J., & Stephens, D. N.
Affiliations
University of Sussex (GB)
Corresponding author
Stephens, David N.
ORCID
Stephens, David N.
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2004-12-24
Volume
179
Issue
1
Pages
164-171
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-004-2071-8
OpenAlex
W2016776306
Cited by
52
References
36
Citations by year
2025: 2 · 2024: 1 · 2022: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 4
FWCI
1.05
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion)
Funders
  • Medical Research Council
  • Biotechnology and Biological Sciences Research Council
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
conditioned place preference, AMPA receptor subunits, GluR1, GluR2, glutamatergic neurotransmission, cocaine reward, food reward, contextual conditioning, stimulus-reward associations
MeSH terms
Amygdala, Animals, Choice Behavior, Cocaine, Conditioning, Classical, Food, Reward, Receptors, AMPA, Mice, Knockout, Mice

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