The DOI matches its Crossref record; 286 of the 286 references it cites were found in a registry or an index.
Striatal ups and downs: Their roles in vulnerability to addictions in humans
Open accessAbstract
Susceptibility to addictive behaviors has been related to both increases and decreases in striatal function. Both profiles have been reported in humans as well as in animal models. Yet, the mechanisms underlying these opposing effects and the manner in which they relate to the behavioral development and expression of addiction remain unclear. In the present review of human studies, we describe a number of factors that could influence whether striatal hyper- or hypo-function is observed and propose a model that integrates the influence of these opposite responses on the expression of addiction related behaviors. Central to this model is the role played by the presence versus absence of addiction related cues and their ability to regulate responding to abused drugs and other rewards. Striatal function and incentive motivational states are increased in the presence of these cues and decreased in their absence. Alternations between these states might account for the progressive narrowing of interests as addictions develop and point to relevant processes to target in treatment.
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“Significant methodological differences across studies, i.e., sample size, subject characteristics, alcohol dose, route of administration, and degree of naturalism to usual contexts(16, 83), hamper direct comparisons to discern the source of this discrepancy.”
From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [83]
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Metadata
- Authors
- Leyton, M., & Vezina, P.
- Affiliations
- McGill University (CA)
- University of Chicago (US)
- Corresponding author
- Leyton, Marco
- Vezina, Paul
- ORCID
- Leyton, Marco
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 37
- Issue
- 9
- Pages
- 1999-2014
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC3743927
- OpenAlex
- W1967611816
- Cited by
- 165
- References
- 284
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 9 · 2020: 53 · 2019: 15 · 2018: 10 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 14 · 2013: 7
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes for Health Research (MOP-36429, MOP-64426)
- National Institutes of Health (DA09397)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- striatum, addiction vulnerability, incentive motivation, drug reward, addiction treatment
- MeSH terms
- Animals, Brain, Cues, Humans, Motivation, Reward, Illicit Drugs, Behavior, Addictive
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