Cited by 165Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesGambling Behavior and Treatments

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Striatal ups and downs: Their roles in vulnerability to addictions in humans

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Leyton, Marco, Vezina, Paul·2013·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2013.01.018PMC PMC3743927

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Abstract

Susceptibility to addictive behaviors has been related to both increases and decreases in striatal function. Both profiles have been reported in humans as well as in animal models. Yet, the mechanisms underlying these opposing effects and the manner in which they relate to the behavioral development and expression of addiction remain unclear. In the present review of human studies, we describe a number of factors that could influence whether striatal hyper- or hypo-function is observed and propose a model that integrates the influence of these opposite responses on the expression of addiction related behaviors. Central to this model is the role played by the presence versus absence of addiction related cues and their ability to regulate responding to abused drugs and other rewards. Striatal function and incentive motivational states are increased in the presence of these cues and decreased in their absence. Alternations between these states might account for the progressive narrowing of interests as addictions develop and point to relevant processes to target in treatment.

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Authors: Leyton, M., & Vezina, P.
Affiliations: McGill University (CA)
University of Chicago (US)
Corresponding author: Leyton, Marco
Vezina, Paul
ORCID: Leyton, Marco
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2013-11
Volume: 37
Issue: 9
Pages: 1999-2014
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2013.01.018
PMC: PMC3743927
OpenAlex: W1967611816
Cited by: 165
References: 284
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 9 · 2020: 53 · 2019: 15 · 2018: 10 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 14 · 2013: 7
FWCI: 1.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Canadian Institutes for Health Research (MOP-36429, MOP-64426)
National Institutes of Health (DA09397)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords: striatum, addiction vulnerability, incentive motivation, drug reward, addiction treatment
MeSH terms: Animals, Brain, Cues, Humans, Motivation, Reward, Illicit Drugs, Behavior, Addictive

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Striatal ups and downs: Their roles in vulnerability to addictions in humans

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