Habenula and ADHD: Convergence on time
Open accessAbstract
Attention deficit/hyperactivity disorder (ADHD) is a childhood-onset psychiatric condition characterized by hyperactivity, impulsivity, and attention deficit. In addition to these core symptoms, accumulating evidence suggests that ADHD may also involve alterations in circadian rhythms, sleep disturbance, and time perception. The habenula is a brain region transmitting limbic information to the midbrain monoamine systems and is thereby involved in the regulation of monoamine release in such target brain areas as the striatum, where it is part of the biological substrates that process time perception. The habenula is additionally a part of the circadian rhythm network and is involved in sleep regulation. Our recent study provides a new insight that a habenula lesion created early in development produces behavioral and brain alterations resembling those observed in ADHD. We propose that the habenula may be a promising target for understanding the pathogenesis of ADHD.
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Mutations in CLOCK gene have been associated with ADHD, indicating that disrupted circadian pathways could exacerbate the symptoms of this disease, including ADHD-associated aggressiveness symptoms.
“Mutations in CLOCK gene have been associated with ADHD, indicating that the disrupted circadian pathways could exacerbate the symptoms of this disease [113], including ADHD-associated aggressiveness symptoms [115].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [113]
The circadian system regulates the dopaminergic system and therefore DA production is subjected to circadian rhythm variations.
“Moreover, the circadian system regulates dopaminergic system and therefore DA production is subjected to circadian rhythm variations [113].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [113]
Circadian rhythm regulates some biological activities such as sleep and mood through various mechanisms such as the TTFL, which includes two transcription activators: CLOCK and BMAL1. Both activators create a heterodimer, which inhibits the transcription of repressor proteins PER2 and CRY that regulates the daily rhythms of locomotor activity, metabolism and behaviour.
“Circadian rhythm regulates some biological activities such as sleep and mood [113] through various mechanisms such as the transcription-translation feedback loop (TTFL), which includes two transcription activators: circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like protein 1 (BMAL1). Both activators create a heterodimer, which inhibits the transcription of repressor pro”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [113]
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“Mutations in CLOCK gene have been associated with ADHD, indicating that the disrupted circadian pathways could exacerbate the symptoms of this disease [113], including ADHDassociated aggressiveness symptoms [115].”
Background
- Authors
- Lee, Y.-A., & Goto, Y.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Goto, Yukiori
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 37
- Issue
- 8
- Pages
- 1801-1809
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2049227749
- Cited by
- 14
- References
- 16
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- habenula, attention deficit hyperactivity disorder, time perception, circadian rhythm, sleep regulation, monoaminergic systems, striatum, ADHD pathogenesis, impulsivity, hyperactivity
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Circadian Rhythm, Humans, Sleep, Sleep Wake Disorders, Time Perception, Habenula
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