Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response.

Activation of 5-HT2 receptors induces glycogenolysis in the rat brain

Darvesh, A. S., & Gudelsky, G. A. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01432-8 · Cited by 30

Distribution of serotonin and its effect on insulin and glucagon secretion in normal and diabetic pancreatic tissues in rat.

Adeghate, E. A., Ponery, A. S., Pallot, D. J., Parvez, S. H., & Singh, J. (1999) · PubMed · Cited by 30

Preference for a Solution of Branched-chain Amino Acids Plus Glutamine and Arginine Correlates with Free Running Activity in Rats: Involvement of Serotonergic-dependent Processes of Lateral Hypothalamus

Smriga, M., Kameishi, M., Tanaka, T., Kondoh, T., & Torii, K. (2002) · Nutritional Neuroscience · doi:10.1080/10284150290028936 · Cited by 28

Attributional style and perceived stress in endogenous and reactive depression

Willner, P., Wilkes, M., & Orwin, A. (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90080-r · Cited by 28

Median Eminence Dopamine and Serotonin Neuronal Activity

Kerdelhué, B., Bojda, F., Lesieur, P., Pasqualini, C., Abed, A. E., Lenoir, V., Douillet, P., Chiueh, M. C., & Palkovits, M. (2008) · Neuroendocrinology · doi:10.1159/000125111 · Cited by 27

Melancholia and partial insanity

Jackson, S. W. (1983) · Journal of the History of the Behavioral Sciences · doi:10.1002/1520-6696(198304)19:2 · Cited by 26

Topological Probes of Monoamine Oxidases A and B in Rat Liver Mitochondria: Inhibition by TEMPO-Substituted Pargyline Analogues and Inactivation by Proteolysis

Wang, J., & Edmondson, D. E. (2011) · Biochemistry · doi:10.1021/bi101722b · Cited by 26

Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with α-[ 14 C]methyl- l -tryptophan 2 2Abbreviations: 5-HT, serotonin, 5-hydroxytryptamine; α-[14C]MTrp, α-[14C]methyl-l-tryptophan; SSRI, selective serotonin reuptake inhibitor; and α-[14C]M5HT, α-[14C]methyl-5-HT.

Yamane, F., Okazawa, H., Blier, P., & Dikšić, M. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00798-5 · Cited by 25

Occurrence and Distribution of 5‐Hydroxytryptophol in the Rat

Cheifetz, S., & Warsh, J. J. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb09945.x · Cited by 25

Experimental Studies on the Role(s) of Serotonin in Learning and Memory Functions

Cassel, J. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70094-1 · Cited by 24

Changes in the levels of glucose 1,6-diphosphate and cyclic GMP, and in the activities of phosphofructokinase and phosphoglucomutase induced by serotonin in muscle

Beitner, R., Frucht, H., & Kaplansky, M. (1983) · International Journal of Biochemistry · doi:10.1016/0020-711x(83)90170-2 · Cited by 24

Role of 5-HT1A receptors in the modulation of stress-induced lactate metabolism in the medial prefrontal cortex and basolateral amygdala

Uehara, T., Sumiyoshi, T., Matsuoka, T., Itoh, H., & Kurachi, M. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0370-y · Cited by 24

Brain SPECT imaging and whole-body biodistribution with [123I]ADAM — a serotonin transporter radiotracer in healthy human subjects

Lin, K., Liu, C., Wey, S., Hsiao, I., Wu, J., Fu, Y.-K., & Yen, T. (2006) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2005.10.006 · Cited by 24

Inescapable shock and attention to internal versus external cues in a water discrimination escape task.

Lee, R. K., & Maier, S. F. (1988) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.14.3.302 · Cited by 24

Masculine sexual behavior features in the Flinders sensitive and resistant line rats

Ferreira-Nuño, A., Overstreet, D. H., Morales-Otal, A., & Velázquez‐Moctezuma, J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00313-8 · Cited by 23

Acute and Chronic D-Fenfluramine Treatments Have Different Effects on Serotonin Synthesis Rates in the Rat Brain: An Autoradiographic Study

Yamane, F., Tohyama, Y., & Dikšić, M. (1999) · Neurochemical Research · doi:10.1023/a:1021120603457 · Cited by 22

Early Symptomatic Worsening During Treatment With Fluoxetine in Major Depressive Disorder: Prevalence and Implications

Cusin, C., Fava, M., Amsterdam, J. D., Quitkin, F. M., Reimherr, F. W., Beasley, C. M., Rosenbaum, J. F., & Perlis, R. H. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0107 · Cited by 22 · cited 2×

Demographic and Clinical Features and Prescribing Patterns of Psychotropic Medications in Patients with the Melancholic Subtype of Major Depressive Disorder in China

Xiang, Y., Wang, G., Hu, C., Guo, T., Ungvari, G. S., Kilbourne, A. M., Lai, K. Y. C., Si, T., Zheng, Q.-W., Chen, D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039840 · Cited by 21

Inhibition of the adenylyl cyclase and activation of the phosphatidylinositol pathway in oocytes through expression of serotonin receptors does not induce oocyte maturation

Noh, S.-J., & Han, J. (1998) · Journal of Experimental Zoology · doi:10.1002/(sici)1097-010x(19980101)280:1 · Cited by 21

Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of the hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia

Ohtani, N., Sugano, T., & Ohta, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01796-5 · Cited by 20

5-HT induces enhanced phrenic nerve activity via 5-HT2A receptor/PKC mechanism in anesthetized rats

Liu, J., Wei, X., Zhao, C., Hu, S.-J., Duan, J.-H., Ju, G., Wong‐Riley, M. T. T., & Liu, Y. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.01.048 · Cited by 20

Systemic Homeostasis and Poikilostasis in Sleep: Is REM Sleep a Physiological Paradox?

Parmeggiani, P. L. (2010) · doi:10.1142/p720#t=toc · Cited by 19

Role of glutamate transporters in the modulation of stress-induced lactate metabolism in the rat brain

Uehara, T., Sumiyoshi, T., Itoh, H., & Kurachi, M. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0881-1 · Cited by 19

A mixed state core for melancholia: an exploration in history, art and clinical science

Akiskal, H. S., & Akiskal, K. K. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00962.x · Cited by 19

Fluvoxamine increased glutamate release by activating both 5-HT(3) and sigma-1 receptors in prelimbic cortex of chronic restraint stress C57BL/6 mice.

Fu, Y.-M., Yu, S.-Y., Guo, X.-Y., Li, X., Li, T.-Y., Li, H.-F., & Dong, Y. (2012) · Biochimica et Biophysica Acta · doi:10.1016/j.bbamcr.2012.01.008 · Cited by 18

Learned Helplessness in Chickens (Gallus gallus): Evidence for Attentional Bias

Rodd, Z. A., Rosellini, R. A., Stock, H. S., & Gallup, G. G. (1997) · Learning and Motivation · doi:10.1006/lmot.1997.0952 · Cited by 18

Role of the serotoninergic system in the acceleration of sexual maturation in wild Norway rats selected for reduced aggressiveness toward humans

Shishkina, G. T., & Дыгало, Н. Н. (2000) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(99)00092-4 · Cited by 18

Serotonin in Panic and Anxiety Disorders

Guimarães, F. S., Zangrossi, H., Del‐Ben, C. M., & Graeff, F. G. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70105-3 · Cited by 17

Activation of Membrane Skeleton-Bound Phosphofructokinase in Erythrocytes Induced by Serotonin

Assouline-Cohen, M., Ben-Porat, H., & Beitner, R. (1998) · Molecular Genetics and Metabolism · doi:10.1006/mgme.1997.2673 · Cited by 17

FREE AND BOUND TRYPTOPHAN IN HUMAN PLASMA DURING THE PERINATAL PERIOD

Tricklebank, M. D., Pickard, F. J., & Souza, S. W. D. (1979) · Acta Paediatrica · doi:10.1111/j.1651-2227.1979.tb04989.x · Cited by 17

The Effects of Peripheral Serotonin2 (5-HT2) and Serotonin3 (5-HT3) Receptor Agonists on Blood Glucose Levels in Rats.

Sugimoto, Y., Yamada, J., Yoshikawa, T., & Horisaka, K. (1996) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.19.1384 · Cited by 16

Blood-brain barrier for serotonin in the eel (Anguilla anguilla L.)

Génot, G., Morfin, R., & Peyraud, C. (1981) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0306-4492(81)90025-3 · Cited by 15

Perseverative instrumental and Pavlovian responding to conditioned stimuli in serotonin transporter knockout rats

Nonkes, L. J. P., & Homberg, J. R. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.12.004 · Cited by 15

Brain metabolic changes following 4‐week citalopram infusion: Increased 18FDG uptake and γ‐amino butyric acid levels

Marsteller, D. A., Barbarich-Marsteller, N. C., Patel, V. D., & Dewey, S. L. (2007) · Synapse · doi:10.1002/syn.20428 · Cited by 14

Antidepressant–placebo differences in 16 clinical trials over 10 years at a single site: role of baseline severity

Khan, A., Bhat, A. S., Faucett, J., Kolts, R. L., & Brown, W. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2107-1 · Cited by 13

Synaptic Depression of the Hyppocampal to Prefrontal Cortex Pathway during a Spatial Working Memory Task

Burette, F., Jay, T. M., & Laroche, S. (2000) · Current psychology letters · doi:10.4000/cpl.104 · Cited by 12

Serotonin Decreases Cytoskeletal and Cytosolic Glycolytic Enzymes and the Levels of ATP and Glucose 1,6-Bisphosphate in Skin, Which Is Prevented by the Calmodulin Antagonists Thioridazine and Clotrimazole

Ashkenazy-Shahar, M., & Beitner, R. (1997) · Biochemical and Molecular Medicine · doi:10.1006/bmme.1996.2562 · Cited by 12

The Evolution of Depressive Phenotypes

Andrews, P. W., & Durisko, Z. (2016) · doi:10.1093/oxfordhb/9780199973965.013.3 · Cited by 11

The 5-HT2C/2B receptor agonist, m-chlorophenylpiperazine, increases plasma glucagon levels in rats

Yamada, J., & Sugimoto, Y. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00644-0 · Cited by 8

Fluoxetine Selectively Alters 5-Hydroxytryptamine1Aand γ-Aminobutyric AcidB Receptor-Mediated Hyperpolarization in Area CA1, but not Area CA3, Hippocampal Pyramidal Cells

Beck, S. G., Birnstiel, S., Choi, K. C., & Pouliot, W. A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36618-2 · Cited by 7

Effect of Five-Consecutive-Day Exposure to an Anxiogenic Stressor on Sleep-Wake Activity in Rats

O’Malley, M. W., Fishman, R. L., Ciraulo, D. A., & Datta, S. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00015 · Cited by 6

Specific binding of serotonin in rat lung

DAS, D. K., & Steinberg, H. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.248.1.e58 · Cited by 6

Démonstration par radioautographie de l'existence d'une barrière hématoencéphalique pour la 5-hydroxytryptamine.

Bouchaud, C. (1972) · Cited by 6

Genetic Organization of the Serotonergic System

D’Souza, U. M., & Craig, I. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70070-9 · Cited by 5

Depression : proceedings of the symposium held at Cambridge 22 to 26 September 1959

Davies, E. (1964) · Medical Entomology and Zoology · Cited by 5

Dissociation of haloperidol-induced “anhedonia” and catalepsy by lesions of the dorsal raphe nucleus

Wirtshafter, D., & Asin, K. E. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90119-m · Cited by 5

Serotonergic augmentation strategies; possibilities and limitations

Jongsma, M. E. (2006) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 2

Inter-individual differences in vulnerability to depression: regional brain energy metabolism, serotonergic function and behaviour in animal models

Kanarik, M. (2011) · DSpace repository (University of Tartu) · Cited by 2

Increased Brain Serotonin Turnover in Panic Disorder: Reduction by a Selective Serotonin Reuptake Inhibitor

Esler, M., Alvarenga, M. E., Lambert, É., Barton, D., Pier, C., Hastings, J., Guo, L. J., Socratous, F., Brenchley, C., & Lambert, G. W. (2007) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/14401614070410s132 · Cited by 2

Measuring Serotonin Activity in vivo in the Brains of Animals and Humans

Marsden, C. A. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70075-8 · Cited by 1

Branched-Chain Amino Acids and Central Fatigue: Implications for Diet and Behavior

Blomstrand, E. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_57 · Cited by 1

Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways.

Lavenex (2000) · Pure Amsterdam UMC · doi:10.1002/1098-1063(2000)10:4 · Cited by 1

The synthesis of atp

Laslop, N. V., & Dreyfus, G. B. J. (1989) · Cited by 1

Untitled work

(2000) · doi:10.1002/1098-2396(20001215)38:4

Untitled work

Black (1996) · doi:10.1002/(sici)1098-108x(199607)20:1

Learned helplessness at fifty: Insights from neuroscience.

Maier, S. F., & Seligman, M. E. P. (2016) · Psychological Review · doi:10.1037/rev0000033 · Cited by 1,031

Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters

Del Giudice, M., & Gangestad, S. W. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.013 · Cited by 779

Serotonin and brain function: a tale of two receptors

Carhart-Harris, R., & Nutt, D. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725915 · Cited by 739

A Unified Model of Depression: Integrating Clinical, Cognitive, Biological, and Evolutionary Perspectives

Beck, A. T., & Bredemeier, K. (2016) · Clinical Psychological Science · doi:10.1177/2167702616628523 · Cited by 510

Prospective biomarkers of major depressive disorder: A systematic review and meta-analysis

Kennis, M., Gerritsen, L., van Dalen, M., Williams, A., Cuijpers, P., & Bockting, C. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0585-z · Cited by 435

A hormetic approach to understanding antidepressant effectiveness and the development of antidepressant tolerance – A conceptual view

Andrews, P. W., & Amsterdam, J. D. (2020) · Psychiatria Polska · doi:10.12740/pp/120084 · Cited by 10

The role of serotonin transmission in antidepressant drug actions

Nwidadah, C. (2023) · University of Debrecen Electronic Archive (University of Debrecen)

[Lights off? Neurobiological and pharmacological aspects of the melatonergic-serotonergic synergism].

Sümegi, A., & Somoskovi, C. (2010) · PubMed · Cited by 2

Paradoxical role of Serotonin in Depression

Waslander, J. (2015)

The Selective Serotonin Reuptake Inhibitors: Antidepressants with Anticonvulsant Effects?

Franco‐Pérez, J. (2014)