The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review
Open accessAbstract
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. Over the past decade, there has been growing evidence for the use of NAC in treating psychiatric and neurological disorders, considering its role in attenuating pathophysiological processes associated with these disorders, including oxidative stress, apoptosis, mitochondrial dysfunction, neuroinflammation and glutamate and dopamine dysregulation. In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy. Disorders such as anxiety, attention deficit hyperactivity disorder and mild traumatic brain injury have preliminary evidence and require larger confirmatory studies while current evidence does not support the use of NAC in gambling, methamphetamine and nicotine addictions and amyotrophic lateral sclerosis. Overall, NAC treatment appears to be safe and tolerable. Further well designed, larger controlled trials are needed for specific psychiatric and neurological disorders where the evidence is favorable.
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“Cognitive studies of NAC have produced inconsistent results, which may be linked to variations in study design [155].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [155]
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Items 201–218 of 218
Das, P., Tanious, M., Fritz, K., Dodd, S., Dean, O. M., Berk, M., & Malhi, G. S. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412474074 · Cited by 28
Self-citationSystemic illness moderates the impact of N-acetyl cysteine in bipolar disorder
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Self-citationN-Acetylcysteine Augmentation to Tranylcypromine in Treatment-Resistant Major Depression
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N‐acetylcysteine in trichotillomania: a panacea for compulsive skin disorders?
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Therapeutic strategies to prevent contrast-induced acute kidney injury
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N-Acetylcysteine (NAC): Impacts on Human Health
Tenório, M. C. D. S., Graciliano, N. G., Moura, F. A., Oliveira, A. C. M. D., & Goulart, M. O. F. (2021) · Antioxidants · doi:10.3390/antiox10060967 · Cited by 526
Nutritional psychiatry: The present state of the evidence
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Self-citationCognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252
Self-citationPeripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197
Amino acid catabolism in Alzheimer’s disease brain: Friend or foe?
Griffin, J. W. D., & Bradshaw, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5472792 · Cited by 185
Metadata
- Authors
- Deepmala, Slattery, J., Kumar, N., Delhey, L., Berk, M., Dean, O., Spielholz, C., & Frye, R.
- Affiliations
- Arkansas Children's Hospital (US)
- Barwon Health (AU)
- MaRS (CA)
- Corresponding author
- Deepmala
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 55
- Pages
- 294-321
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W240506283
- Cited by
- 463
- References
- 218
- Citations by year
- 2026: 28 · 2025: 35 · 2024: 38 · 2023: 38 · 2022: 38 · 2021: 38 · 2020: 49 · 2019: 51 · 2018: 47 · 2017: 50 · 2016: 42 · 2015: 8
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Geelong Region Medical Research Foundation
- Simons Foundation Autism Research Initiative
- Australian Rotary Health
- Beyond Blue
- Servier
- H. Lundbeck A/S
- National Institutes of Health (1059660)
- National Health and Medical Research Council (1078928, 1061043, 1059660)
- Cilag
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- N-acetylcysteine, mental illness, neurological disorders, autism spectrum disorder, Alzheimer's disease, addiction, bipolar disorder, depression, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy, progressive myoclonic epilepsy, oxidative stress, neuroinflammation, glutamate dysregulation, dopamine dysregulation, mitochondrial dysfunction, treatment safety
- MeSH terms
- Acetylcysteine, Adolescent, Adult, Mental Disorders, Clinical Trials as Topic, Female, Humans, Male, Nervous System Diseases, Neurology, Psychiatry, Randomized Controlled Trials as Topic, Treatment Outcome, Young Adult
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